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2025-12-5 20:22:36
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GIP, GISRS. Influenza at the human-animal interface summary and assessment, 1 July 2025. WHO.  Abstract  
submitted by kickingbird at Jul, 15, 2025 from WHO (via https://cdn.who.int/media/docs/default-source/influenza/huma)
From 28 May to 1 July 2025, based on reporting date, the detection of influenza A(H5N1) in nine humans, influenza A(H9N2) in three humans and influenza A(H10N3) in one human were reported officially. Additionally, ...

De Mathia F, Kargl T, Müller M, Erdem I, Hayes B,. Purification and characterization of recombinant neuraminidase as a potentially broadly protective influenza virus vaccine candidate. Vaccine. 2025 Jul 11;62:127471.  Abstract  
submitted by kickingbird at Jul, 14, 2025 from Vaccine. 2025 Jul 11;62:127471 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Influenza viruses pose a significant public health threat, causing seasonal epidemics and occasional pandemics with substantial morbidity and mortality worldwide. The development of effective vaccines ...

WPRO. Avian Influenza Weekly Update # 1005: 11 July 2025. WHO.  Abstract  
submitted by kickingbird at Jul, 14, 2025 from WHO (via https://cdn.who.int/media/docs/default-source/wpro---documen)
Avian influenza subtype A(HxNy) normally spreads in birds but can also infect humans. Human infections are primarily acquired through direct contact with infected poultry or contaminated environments. ...

Khan MY, Shah AU, Duraisamy N, Cherkaoui M, Hemida. Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach. Viruses. 2025; 17(7):972.  Abstract  
submitted by kickingbird at Jul, 14, 2025 from Viruses. 2025; 17(7):972 (via https://www.mdpi.com/1999-4915/17/7/972)
Background: The highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b is an emerging threat that poses a great risk to the poultry industry. A few human cases have been linked to the infection with ...

Liu F, Chang J, Huang J, Liao Y, Deng X, Guo T, Ko. Surface Display of Avian H5 and H9 Hemagglutinin Antigens on Non-Genetically Modified Lactobacillus Cells for Bivalent Oral AIV Vaccine Development. Microorganisms. 2025; 13(7):1649.  Abstract  
submitted by kickingbird at Jul, 14, 2025 from Microorganisms. 2025; 13(7):1649 (via https://www.mdpi.com/2076-2607/13/7/1649)
A novel bivalent oral vaccine candidate against H5N1 and H9N2 avian influenza virus (AIV) was developed using Lactobacillus surface display technology without genetic modification. The hemagglutinin subunit ...

Andreasen VA, Phillips EG, O’Reilly AM, Stilz CR, P. Clade 2.3.4.4b Highly Pathogenic Avian Influenza H5N1 Pathology in a Common Shorebird Species (Sanderling; Calidris alba) in Virginia, USA. Animals. 2025; 15(14):2057.  Abstract  
submitted by kickingbird at Jul, 14, 2025 from Animals. 2025; 15(14):2057 (via https://www.mdpi.com/2076-2615/15/14/2057)
Anseriformes (waterfowl) and Charadriiformes (shorebirds) are well-recognized natural reservoirs of low pathogenic (LP) influenza A viruses (IAVs). Historically, LP IAVs circulate among healthy individuals ...

Huang, C. Q. et al. Computationally designed haemagglutinin with nanocage plug-and-display elicits pan-H5 influenza vaccine responses. Emerging Microbes & Infections, 14(1).  Abstract  
submitted by kickingbird at Jul, 14, 2025 from Emerging Microbes & Infections, 14(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The increasing spread of highly pathogenic avian influenza (HPAI) A/H5 viruses poses a pandemic threat. Circulating clade 2.3.4.4b viruses have demonstrated rapid transcontinental dissemination, extensive ...

Vasilev, K., Hoxie, I., Puente-Massaguer, E. et al. Immunogenicity and protective efficacy of an intranasal neuraminidase-based influenza vaccine with bacterial cell membrane-derived adjuvants. npj Vaccines 10, 149 (2025).  Abstract  
submitted by kickingbird at Jul, 14, 2025 from npj Vaccines 10, 149 (2025) (via https://link.springer.com/article/10.1038/s41541-025-01209-7)
Development of mucosal influenza virus vaccines which protect the site of viral entry is of high importance. Recombinant neuraminidase (NA) has emerged as an antigenically conserved intranasal vaccine ...

Nemoto, M., Kawanishi, N., Kambayashi, Y. et al. Growth properties of recombinant equine influenza viruses with different backbones generated by reverse genetics in embryonated chicken eggs. Arch Virol 170, 181 (2025).  Abstract  
submitted by kickingbird at Jul, 13, 2025 from Arch Virol 170, 181 (2025) (via https://link.springer.com/article/10.1007/s00705-025-06368-5)
Reverse genetics (RG) technology is useful for quickly updating influenza vaccine strains. A high-yield backbone (i.e., six segments other than hemagglutinin and neuraminidase) derived from A/Puerto Rico/8/1934 ...

Mostafa, A., Ye, C., Barre, R.S. et al. A live attenuated NS1-deficient vaccine candidate for cattle-origin influenza A (H5N1) clade 2.3.4.4.b viruses. npj Vaccines 10, 151 (2025).  Abstract  
submitted by kickingbird at Jul, 13, 2025 from npj Vaccines 10, 151 (2025) (via https://link.springer.com/article/10.1038/s41541-025-01207-9)
Avian Influenza viruses (AIVs) present a public health risk, especially with seasonal vaccines offering limited protection. AIV H5N1 clade 2.3.4.4b has caused a multi-state outbreaks in the United States ...

Cunningham MW, Brown J, Hardman R, Loerzel S, Klue. Outbreaks of Highly Pathogenic H5N1 Influenza A Virus infection in Black Vultures (Coragyps atratus), USA, 2022. J Wildl Dis. 2025 Jul 11.  Abstract  
submitted by kickingbird at Jul, 11, 2025 from J Wildl Dis. 2025 Jul 11 (via https://meridian.allenpress.com/jwd/article/doi/10.7589/JWD-)
Mortalities in Black Vultures (Coragyps atratus) caused by A/goose/Guangdong/1/1996 2.3.4.4b lineage highly pathogenic (HP) influenza A virus (IAV) H5N1 (HP H5N1) were detected in Florida, USA, on 14 February ...

Song Y, Zhang X, Ji J, Li L, Zhou Y, Ren G, Lv S,. Genetic characteristics analysis of influenza A(H1N1) virus in Jiaxing, China, in the postepidemic era. BMC Infect Dis. 2025 Jul 10;25(1):905.  Abstract  
submitted by kickingbird at Jul, 11, 2025 from BMC Infect Dis. 2025 Jul 10;25(1):905 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
Background: Following the lifting of COVID-19 pandemic control measures, a progressive increase in influenza A virus activity, particularly the H1N1 subtype, has been observed in Jiaxing. This study systematically ...

Mosaad Z, Hagag NM, Elsayed MM, Mady WH, Zanaty AM. Isolation, characterization and phylogenetic analyses of avian influenza A (H9N2) viruses isolated from poultry between 2019 and 2023 in Egypt. BMC Vet Res. 2025 Jul 11;21(1):455.  Abstract  
submitted by kickingbird at Jul, 11, 2025 from BMC Vet Res. 2025 Jul 11;21(1):455 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
The current study aimed to investigate the genetic characterization and evolution of low pathogenic avian influenza virus H9N2 in Egypt. Ten H9N2 viruses were recently isolated from samples collected between ...

Neira V, Ariyama N, Castillo-Torres PN, Brito B, M. Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b, Antarctica, 2024. Emerg Infect Dis. 2025 Jul 9;31(8).  Abstract  
submitted by kickingbird at Jul, 11, 2025 from Emerg Infect Dis. 2025 Jul 9;31(8) (via https://wwwnc.cdc.gov/eid/article/31/8/25-0186_article)
In 2024, we sequenced highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b genomes isolated from 5 brown skuas from James Ross Island, Antarctica. Phylogenetic analysis suggested the virus reached ...

Seo YR, Cho AY, Kim DJ, Si YJ, Jeong HS, Lee SW, S. Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N1) and A(H5N6) Viruses in Wild Birds, South Korea, 2023-2024. Emerg Infect Dis. 2025 Jul 9;37(8).  Abstract  
submitted by kickingbird at Jul, 11, 2025 from Emerg Infect Dis. 2025 Jul 9;37(8) (via https://wwwnc.cdc.gov/eid/article/31/8/25-0373_article)
We analyzed 15 cases of highly pathogenic avian influenza (HPAI) clade 2.3.4.4b virus infections detected in wild birds in South Korea during September 2023-March 2024. We isolated and sequenced 8 H5N1 ...

Biswas A, Eisfeld AJ, Guan L, Gu C, Wang T, Abozei. Susceptibility and shedding in Mx1+ and Mx1- female mice experimentally infected with dairy cattle A(H5N1) influenza viruses. EBioMedicine. 2025 Jul 8;118:105842.  Abstract  
submitted by kickingbird at Jul, 11, 2025 from EBioMedicine. 2025 Jul 8;118:105842 (via https://www.thelancet.com/journals/ebiom/article/PIIS2352-39)
Background: Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) (HPAI H5N1) viruses have spread prolifically in dairy cattle in the US, resulting in dozens of human infections, some without well-established ...

Zhang T, Du J, Cao Y, Han H, Du Y, Hou Y, Du Q, So. Comparative study of rapid influenza antigen tests versus PCR in an influenza-like illness population: A real-world multicenter study in China. Infect Genet Evol. 2025 Jul 7:105794.  Abstract  
submitted by kickingbird at Jul, 11, 2025 from Infect Genet Evol. 2025 Jul 7:105794 (via https://www.sciencedirect.com/science/article/pii/S156713482)
This study aimed to explore the differences in detection between polymerase chain reaction (PCR) and rapid influenza antigen test (RIAT) in a population with influenza-like illness (ILI). A retrospective ...

Signore AV, Giacinti J, Jones MEB, Erdelyan CNG, M. Spatiotemporal reconstruction of the North American A(H5N1) outbreak reveals successive lineage replacements by descendant reassortants. Sci Adv. 2025 Jul 11;11(28):eadu4909.  Abstract  
submitted by kickingbird at Jul, 10, 2025 from Sci Adv. 2025 Jul 11;11(28):eadu4909 (via https://www.science.org/doi/10.1126/sciadv.adu4909)
The November 2021 introduction of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b into North America triggered a devastating outbreak, affecting more than 180 million domestic birds and spreading ...

Blaney K, Cardamone L, Clarke NE, Hayes MJ, Muleme. Responding to avian influenza in poultry farms in Victoria, Australia. Bull World Health Organ. 2025 Jul 1;103(7):437-444.  Abstract  
submitted by kickingbird at Jul, 10, 2025 from Bull World Health Organ. 2025 Jul 1;103(7):437-444 (via https://pmc.ncbi.nlm.nih.gov/articles/PMC12231074/)
Objective: To describe a multi-agency public response to an outbreak of avian influenza virus in poultry farms in Victoria, Australia, in 2024.Methods: After detecting an outbreak of high-pathogenicity ...

Kandel S, Babujee L, Guan L, Dahn R, Pattinson D,. Phylogenetic analysis of H5N1 influenza viruses isolated from dairy cattle in Texas in December 2024. J Virol. 2025 Jul 8:e0058025.  Abstract  
submitted by kickingbird at Jul, 9, 2025 from J Virol. 2025 Jul 8:e0058025 (via https://journals.asm.org/doi/10.1128/jvi.00580-25)
Highly pathogenic avian influenza (HPAI) viruses of genotype B3.13 were first reported in dairy cattle in March 2024 and, by 4 March 2025, had infected at least 989 cattle herds in 17 states in the US ...

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