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2025-12-5 16:59:46
Article

Dondi A, Guida F, Trombetta L, De Peppo Cocco M, P. Burden and Clinical Characteristics of Influenza and Its Complications in Children Across Multiple Epidemic Seasons. Viruses. 2025; 17(12):1574.  Abstract  
submitted by kickingbird at 4 days ago from Viruses. 2025; 17(12):1574 (via https://www.mdpi.com/1999-4915/17/12/1574)
Seasonal influenza is a major cause of morbidity and hospitalization in children, with the potential for severe complications and considerable socioeconomic impact. We conducted a retrospective observational ...

Baker PH, Glendenning LM, Oliveira MXS, Cobb BA, E. Distribution of sialic acids in the bovine mammary gland across different physiological states. J Dairy Sci. 2025 Nov 27:S0022-0302(25)00977-4.  Abstract  
submitted by kickingbird at 4 days ago from J Dairy Sci. 2025 Nov 27:S0022-0302(25)00977-4 (via https://www.journalofdairyscience.org/article/S0022-0302(25))
Highly pathogenic avian influenza (HPAI) A(H5N1) virus emerged in lactating dairy cattle in March 2024, causing mastitis-related disease and infections in other farm animals and workers. Recent work identified ...

Ziqin Song, etc.,al. Dual signal amplification strategy: CRISPR/Cas9 trans-cleavage combined with strand displacement amplification for influenza virus detection. Microchemical Journal.  Abstract  
submitted by kickingbird at 4 days ago from Microchemical Journal (via https://www.sciencedirect.com/science/article/abs/pii/S00262)
The core effector protein, Cas9 of the CRISPR/Cas9 system is capable of recognizing and cleaving target DNA sequences under the guidance of guide RNA (gRNA). This study developed a novel platform for detecting ...

Dylan Andrieux, etc.,al. [preprint]Detection and isolation of H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus from ticks (Ornithodoros maritimus) recovered from a naturally infected slender-billed gull (Chroicoce. https://doi.org/10.1101/2025.11.28.689408.  Abstract  
submitted by kickingbird at 5 days ago from https://doi.org/10.1101/2025.11.28.689408 (via https://www.biorxiv.org/content/10.1101/2025.11.28.689408v1)
Laridae birds, such as gulls, are known reservoirs of H13 and H16 low pathogenic avian influenza subtypes. However, during the recent outbreaks linked to the reemergence of high pathogenicity avian influenza ...

Hatta, M., Brock, N., Hauguel, T. et al. Influenza mRNA vaccine reduces pathogenicity and transmission of A(H5N1) virus in a ferret model. npj Vaccines (2025).  Abstract  
submitted by kickingbird at 5 days ago from npj Vaccines (2025) (via https://link.springer.com/article/10.1038/s41541-025-01318-3)
The global spread of highly pathogenic avian influenza A(H5N1) viruses poses a serious pandemic threat. While sustained human-to-human transmission has not occurred, widespread circulation in birds, increased ...

Rahul K. Nelli, etc.,al. Exploring influenza A virus receptor distribution in the lactating mammary gland of domesticated livestock and in human breast tissue. Journal of Dairy Science.  Abstract  
submitted by kickingbird at 5 days ago from Journal of Dairy Science (via https://www.sciencedirect.com/science/article/pii/S002203022)
The spread of the highly pathogenic avian influenza (HPAI) H5N1 virus in dairy cattle, particularly affecting the mammary glands, highlights the adaptability of influenza A viruses (IAV) to infect nontraditional ...

David C. Brice, etc.,al. Immunogenicity and efficacy of commercial poultry avian influenza vaccines against HPAI A(H5N1) clade 2.3.4.4b viruses in Mexico. Virology.  Abstract  
submitted by kickingbird at 5 days ago from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
The high-pathogenicity avian influenza A(H5N1) viruses of clade 2.3.4.4b have been detected in domestic poultry and wild birds in Mexico. Vaccination with H5 vaccines has been implemented as a complementary ...

Nayduch, D., Scroggs, S.L., Shults, P. et al. Detection of H5N1 highly pathogenic avian influenza virus RNA in filth flies collected from California farms in 2024. Sci Rep (2025).  Abstract  
submitted by kickingbird at 6 days ago from Sci Rep (2025) (via https://www.nature.com/articles/s41598-025-29856-9)
The emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b in U.S. dairy cattle highlights the urgent need to understand transmission dynamics within and among farms. House flies (Musca ...

Zhang M, Qin L, Li Z, Chen J, Tong J, Ding X, Li H. Dominant substitutions underlying the antigenic evolution of H5 influenza virus. Nat Commun. 2025 Nov 28;16(1):10708.  Abstract  
submitted by kickingbird at 6 days ago from Nat Commun. 2025 Nov 28;16(1):10708 (via https://www.nature.com/articles/s41467-025-65730-y)
Highly pathogenic avian influenza (HPAI) H5 viruses have recently been documented in mammals including humans, posing a major threat to global public health. To prevent a potential H5 pandemic, it is critical ...

Pollett SD, Hone E, Richard SA, Schmidt K, Simons. The Epidemiology, Phylogeny, and Strain Antigenicity of an Influenza A/H3N2 Virus Outbreak Among Vaccinated US Navy Midshipmen. Influenza Other Respir Viruses. 2025 Dec;19(12):e7.  Abstract  
submitted by kickingbird at 6 days ago from Influenza Other Respir Viruses. 2025 Dec;19(12):e7 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70184)
We performed epidemiological, genetic, and antigenic characterization of an influenza A/H3N2 outbreak in a congregate setting of young adults with high vaccination rates. We noted substantial duty-days ...

Huang A, Liu Y, Li Y, Yin Z, Huo S, Wang J, Yang Z. Recombinant expression and functional characterization of influenza A virus neuraminidase in a mammalian cell system. Front Microbiol. 2025 Nov 12;16:1729393.  Abstract  
submitted by kickingbird at 6 days ago from Front Microbiol. 2025 Nov 12;16:1729393 (via https://www.frontiersin.org/journals/microbiology/articles/1)
The soluble and functional expression of influenza A virus neuraminidase (NA) remains a major challenge due to its membrane-associated nature and structural complexity. In this study, we established a ...

Hongying Chen, etc.,al. [preprint]NSUN2-dependent 5-methylcytosine Modification Regulates Influenza A virus Gene Expression and Genomic Packaging. https://doi.org/10.1101/2025.11.26.690652.  Abstract  
submitted by kickingbird at 7 days ago from https://doi.org/10.1101/2025.11.26.690652 (via https://www.biorxiv.org/content/10.1101/2025.11.26.690652v1)
Emerging evidence indicates that methyltransferase NSUN2 catalyzes 5-methylcytosine (m5C) modifications on various viral RNAs and plays important roles in viral biology. However, the regulatory roles of ...

Christopher Ruis, etc.,al. [preprint]Mutational spectra reveal influenza virus transmission routes and adaptation. https://doi.org/10.1101/2025.11.26.690773.  Abstract  
submitted by kickingbird at 7 days ago from https://doi.org/10.1101/2025.11.26.690773 (via https://www.biorxiv.org/content/10.1101/2025.11.26.690773v1)
Influenza A virus remains a major cause of morbidity and mortality in humans and animals with pandemic potential. While control of outbreaks and spillover events remains a key health priority, the transmission ...

Wu Y, Long Y, Yang X, Du X, Du X, Zahan N, Deng Z,. Harnessing a Surface Water-Based Multifaceted Approach to Combat Zoonotic Viruses: A Rural Perspective from Bangladesh and China. Microorganisms. 2025; 13(11):2526.  Abstract  
submitted by kickingbird at 7 days ago from Microorganisms. 2025; 13(11):2526 (via https://www.mdpi.com/2076-2607/13/11/2526)
Rural tropical regions face escalating threats from zoonotic AIV and dengue virus but lack sewered infrastructure for conventional wastewater surveillance. We implemented surface water-based surveillance ...

Turnbull ML, Wang Y, Clare S, Lieber G, Williams S. Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals. Science. 2025 Nov 27;390(6776):eadq4691.  Abstract  
submitted by kickingbird at 7 days ago from Science. 2025 Nov 27;390(6776):eadq4691 (via https://www.science.org/doi/10.1126/science.adq4691)
Host body temperature can define a virus's replicative profile-influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted to ...

Guo J, Jung B, Yoon SW, Liu Y, Feng Z, Yeom M, Na. Negative regulation of reassortant canine influenza virus replication and key site identification in porcine and ferret bronchial epithelial cell lines. Virulence. 2025 Nov 27:2595767.  Abstract  
submitted by kickingbird at 7 days ago from Virulence. 2025 Nov 27:2595767 (via https://www.tandfonline.com/doi/full/10.1080/21505594.2025.2)
The segmented nature and high mutability of the influenza virus RNA genome facilitate rapid mutation and reassortment, allowing the virus to breach host barriers and migrate between different species, ...

Wu M, Wang M, Zeng X, Zhang K, Wang M, Xu G, Wang. HA protein acetylation modulates replication, pathogenicity, and immunogenicity of influenza virus and facilitates live-attenuated vaccine design. Emerg Microbes Infect. 2025 Nov 27:2595799.  Abstract  
submitted by kickingbird at 7 days ago from Emerg Microbes Infect. 2025 Nov 27:2595799 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Lysine acetylation, a form of protein post-translational modifications (PTM), is known to play crucial roles in regulating cellular and physiological processes. In this study, for the first time, lysine ...

Xiong W, Yin H, Gao L, Liang S. Global Trends in Influenza and Meningitis Research: A Comprehensive Bibliometric and Visualization Analysis (1980-2024). J Multidiscip Healthc. 2025 Nov 21;18:7609-7625.  Abstract  
submitted by kickingbird at 7 days ago from J Multidiscip Healthc. 2025 Nov 21;18:7609-7625 (via https://www.dovepress.com/global-trends-in-influenza-and-men)
Background: Influenza and meningitis are interconnected through shared epidemiological patterns and complications, with influenza often leading to bacterial meningitis by compromising host immunity. This ...

Anselmo Vasconcelos Rivetti Jr, etc.,al. Genomic Diversity and Reassortment of Highly Pathogenic Avian Influenza A/H5N1 Virus (Clade 2.3.4.4b) in Brazil: Evidence of Multiple Introductions and Intra-Epidemic Reassortment in 2025. Virology.  Abstract  
submitted by kickingbird at 7 days ago from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Highly pathogenic avian influenza (HPAI) A/H5N1, clade 2.3.4.4b, has spread globally, with the first outbreak in a commercial poultry farm in Brazil reported in 2025. This study aimed to genetically characterize ...

Chang Li. Genetic evolutionary dynamics and interspecies transmission risk of H9N2 subtype of avian influenza viruses. Animals and Zoonoses.  Abstract  
submitted by kickingbird at 7 days ago from Animals and Zoonoses (via https://www.sciencedirect.com/science/article/pii/S295024892)
Since its initial isolation from a turkey flock in Wisconsin, USA, in 1966, the H9N2 subtype of avian influenza virus (AIV) has emerged as a significant threat to the global poultry industry and human ...

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