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2025-12-5 19:38:16
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David W. Hawman et al. A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge. Sci. Transl. Med.17,eadw4646 (2025).  Abstract  
submitted by kickingbird at Oct, 9, 2025 from Sci. Transl. Med.17,eadw4646 (2025) (via https://www.science.org/doi/10.1126/scitranslmed.adw4646)
In early 2024, clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A H5N1 virus was detected in United States dairy cattle. Although so far the public health threat of contemporary clade 2.3.4.4b H5N1 ...

Ismaila Shittu, etc.,al. [preprint]Sustained High Levels of Antibodies to Avian Influenza Virus H5N1 Clade 2.3.4.4b in Naturally Infected Cattle. https://doi.org/10.21203/rs.3.rs-7274486/v1.  Abstract  
submitted by kickingbird at Oct, 9, 2025 from https://doi.org/10.21203/rs.3.rs-7274486/v1 (via https://www.researchsquare.com/article/rs-7274486/v1)
Cattle were not previously thought susceptible to highly pathogenic avian influenza (HPAI) H5N1 virus infection until March 2024, when outbreaks were reported among dairy cattle. Data are sparse regarding ...

Diletta Fornasiero, etc.,al. [preprint]Continuous phylogeography reveals shifting environmental drivers of Highly Pathogenic Avian Influenza H5 spread. https://doi.org/10.21203/rs.3.rs-7636570/v1.  Abstract  
submitted by kickingbird at Oct, 9, 2025 from https://doi.org/10.21203/rs.3.rs-7636570/v1 (via https://www.researchsquare.com/article/rs-7636570/v1)
The ongoing global spread of highly pathogenic avian influenza (HPAI) continues causing major impacts on poultry, wildlife, and public health. Among the most affected countries in Europe, Italy experienced ...

Clessin, A., Briand, FX., Tornos, J. et al. Circumpolar spread of avian influenza H5N1 to southern Indian Ocean islands. Nat Commun 16, 8463 (2025).  Abstract  
submitted by kickingbird at Oct, 9, 2025 from Nat Commun 16, 8463 (2025) (via https://link.springer.com/article/10.1038/s41467-025-64297-y)
Since 2020, the outbreak of high pathogenicity avian influenza (HPAI) H5N1 virus clade 2.3.4.4b has turned into the largest documented panzootic 1,3. Here, we describe its arrival into the Indian Ocean ...

Nooruzzaman, M., de Oliveira, P.S.B., Butt, S.L. e. H5N1 influenza virus stability and transmission risk in raw milk and cheese. Nat Med (2025).  Abstract  
submitted by kickingbird at Oct, 9, 2025 from Nat Med (2025) (via https://link.springer.com/article/10.1038/s41591-025-04010-0)
Highly pathogenic avian influenza H5N1 viruses have recently spread to dairy cattle, with high levels of virus detected in milk from affected animals, raising concern about the risk posed by unpasteurized ...

Barre RS, Mostafa A, Chiem K, Pearl RL, Platt RN,. Bioluminescent reporter influenza A viruses to track viral infections. Microbiol Spectr 0:e02150-25.  Abstract  
submitted by kickingbird at Oct, 8, 2025 from Microbiol Spectr 0:e02150-25 (via https://journals.asm.org/doi/10.1128/spectrum.02150-25)
Influenza A viruses (IAVs) infect a wide range of mammalian and bird species and are responsible for seasonal outbreaks and occasional pandemics of great consequences in humans. Studying IAVs requires ...

Sally M Kephart, etc.,al. [preprint]Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation Dynamics. https://doi.org/10.1101/2025.10.06.680362.  Abstract  
submitted by kickingbird at Oct, 8, 2025 from https://doi.org/10.1101/2025.10.06.680362 (via https://www.biorxiv.org/content/10.1101/2025.10.06.680362v1)
Increase in the occurrence of human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI ...

Umar S, Ahmed A, Gulraiz SH, Muhammad S, Yu J, Ras. First Report of Influenza D Virus in Dairy Cattle in Pakistan. Viruses. 2024; 16(12):1865.  Abstract  
submitted by kickingbird at Oct, 7, 2025 from Viruses. 2024; 16(12):1865 (via https://www.mdpi.com/1999-4915/16/12/1865)
Influenza D virus (IDV) is a newly emerged zoonotic virus increasingly reported worldwide. Cattle are considered the main reservoir of IDV, although it was first isolated from pigs. IDV infects multiple ...

Hada A, Xiao Z. T Cell Responses to Influenza Infections in Cattle. Viruses. 2025; 17(8):1116.  Abstract  
submitted by kickingbird at Oct, 7, 2025 from Viruses. 2025; 17(8):1116 (via https://www.mdpi.com/1999-4915/17/8/1116)
Influenza viruses are major threats to global health, with potential to cause widespread disease in both humans and animals. Cattle, once considered resistant, are susceptible hosts for multiple influenza ...

Fernanda Sanchez-Rodriguez, etc.,al. [preprint]Highly pathogenic avian influenza (HPAI) in South America, 2022-2025: temporality, affected species, and the southwards expansion to the Antarctic region.. https://doi.org/10.1101/2025.10.03.680239.  Abstract  
submitted by kickingbird at Oct, 6, 2025 from https://doi.org/10.1101/2025.10.03.680239 (via https://www.biorxiv.org/content/10.1101/2025.10.03.680239v1)
The H5N1 highly pathogenic avian influenza (HPAI) virus has caused severe global losses, reaching South America in 2022 and Antarctica in 2024. Here we synthesize outbreak reports submitted to the World ...

Rosemary Anna Blake, etc.,al. [preprint]Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screen. https://doi.org/10.1101/2025.10.03.680283.  Abstract  
submitted by kickingbird at Oct, 6, 2025 from https://doi.org/10.1101/2025.10.03.680283 (via https://www.biorxiv.org/content/10.1101/2025.10.03.680283v1)
Influenza A virus (IAV) causes major economic losses to the poultry industry and poses a zoonotic threat to human health. Potential pandemic outbreaks are underpinned by the ability of the virus to jump ...

Xiang Li, etc.,al. Zoonotic Threat: Emergence of Mammalian-Adapted H5N1 Virus in Migratory Birds at Qinghai Lake. Journal of Infection.  Abstract  
submitted by kickingbird at Oct, 5, 2025 from Journal of Infection (via https://www.sciencedirect.com/science/article/pii/S016344532)
In October 2020, a novel clade 2.3.4.4b H5N1 highly pathogenic avian influenza virus (HPAIV) was first detected in wild ducks in the Netherlands and rapidly disseminated globally, causing unprecedented ...

Sare Golpasand et al. Exploring the molecular and biological mechanisms of host response in chickens infected with highly pathogenic avian influenza virus (H5N1): An integrative transcriptomic analysis. PLoS One. 2025.  Abstract  
submitted by kickingbird at Oct, 5, 2025 from PLoS One. 2025 (via https://pubmed.ncbi.nlm.nih.gov/41042757/)
The H5N1 strain of highly pathogenic avian influenza (HPAI) has raised worldwide alarm, posing a threat to the health of both animals and humans. The study aimed to identify key genes and biological pathways ...

Nahid Bhadelia, Rick A. Bright, Vanessa Moeder. Diagnostic Tools, Gaps, and Collaborative Pathways in Human H5N1 Detection: Rapid Expert Consultation (2025). National Academies of Sciences, Engineering, and M.  Abstract  
submitted by kickingbird at Oct, 5, 2025 from National Academies of Sciences, Engineering, and M (via https://nap.nationalacademies.org/catalog/29273/diagnostic-t)
Diagnostics are the first line of defense to infectious disease outbreaks. The rapid spread of Influenza A (H5N1) or "Bird Flu" into U.S. dairy cattle, poultry, and humans underscores the urgent need for ...

An SH, Heo GB, Kang YM, Lee YJ, Lee KN. Development of a multiplex and universal RT-PCR assay for hemagglutinin and neuraminidase subtyping of avian influenza virus. J Vet Sci. 2025 Sep;26(5):e59.  Abstract  
submitted by kickingbird at Oct, 5, 2025 from J Vet Sci. 2025 Sep;26(5):e59 (via https://vetsci.org/DOIx.php?id=10.4142/jvs.25066)
Importance: Avian influenza virus (AIV) is classified into subtypes by hemagglutinin (HA) and neuraminidase (NA) genes. Wild waterfowl harbor H1-H16 and N1-N9 subtypes. Large-scale AIV surveillance requires ...

Anne Günther, etc.,al. [preprint]Opportunity Drives Spillover: Serological Surveillance across Carnivores, Omnivores and Herbivores in an HPAIV H5 Hotspot in North-East Germany, 2023-2025. https://doi.org/10.1101/2025.09.30.678011.  Abstract  
submitted by kickingbird at Oct, 4, 2025 from https://doi.org/10.1101/2025.09.30.678011 (via https://www.biorxiv.org/content/10.1101/2025.09.30.678011v1)
In North-East Germany's offshore islands and mainland coast, wild ruminants, boar, and carnivores were tested for H5-HPAI antibodies. Wild ruminants were seronegative; 3.5% of boar and 12.5-21.9% of carnivores ...

Valerie Le Sage, etc.,al. [preprint]Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk. https://doi.org/10.1101/2025.10.02.679960.  Abstract  
submitted by kickingbird at Oct, 4, 2025 from https://doi.org/10.1101/2025.10.02.679960 (via https://www.biorxiv.org/content/10.1101/2025.10.02.679960v1)
In China, low pathogenic avian influenza (LPAI) H3N8 virus is widespread among chickens and has recently caused three zoonotic infections, with the last one in 2023 being fatal. Here we evaluated the relative ...

Joly DO, Berhane Y, Bowman J, Giacinti JA, Goldsmi. Highly Pathogenic Avian Influenza (HPAI) Detected in 41 Species at Risk in Canada. J Wildl Dis. 2025 Oct 6.  Abstract  
submitted by kickingbird at Oct, 4, 2025 from J Wildl Dis. 2025 Oct 6 (via https://pubmed.ncbi.nlm.nih.gov/41043086/)
Highly pathogenic avian influenza (HPAI) H5Nx virus clade 2.3.4.4b has impacted wild birds and mammals in Canada since late 2021, including species at risk. We compared detections and conservation status ...

Pablo Plaza, etc.,al. Wild Birds Affected by Highly Pathogenic Avian Influenza A (H5N1) Worldwide: Epidemiological Insights Into the Recent Panzootic. Global Change Biology.  Abstract  
submitted by kickingbird at Oct, 3, 2025 from Global Change Biology (via https://onlinelibrary.wiley.com/doi/10.1111/gcb.70523)
In recent years, especially as a consequence of global change, several emerging pathogens have caused alarming effects in wild species. One of these pathogens, the Highly Pathogenic Avian Influenza A (H5N1), ...

ECDC. Influenza virus characteristics, week 40 2024 to week 33 2025, EU/EEA. European Centre for Disease Prevention and Control.  Abstract  
submitted by kickingbird at Oct, 3, 2025 from European Centre for Disease Prevention and Control (via https://www.ecdc.europa.eu/en/publications-data/influenza-vi)
Within the reporting period, 354 455 influenza virus detections (sentinel and non-sentinel combined) were reported, of which 73% (257 761) were type A and 26% (90 873) were type B virus; another 1.6% (5 ...

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