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2026-3-6 21:33:10
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Harrell T.L., Shwani A., Suarez D.L. The Impact of Acids, pH, and Incubation Time on Avian Influenza Virus Persistence in Raw Milk. Food Microbiology.  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Food Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S07400)
In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4.b H5N1 was detected in dairy cattle. Since detection, the virus has spread across 17 states, infecting more than 1000 dairy ...

Ane Marie Anderson, etc.,al. DNA vaccines targeting hemagglutinin from 18 subtypes of influenza A virus to antigen presenting cells confer broad protection. Molecular Therapy Nucleic Acids.  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Molecular Therapy Nucleic Acids (via https://www.sciencedirect.com/science/article/pii/S216225312)
Novel vaccines that confer broad protection against influenza A viruses (IAV) are urgently needed. Hemagglutinin (HA) is the major influenza antigen targeted by protective immune responses. We have here ...

Zhu, T., Zhu, M., Lu, F. et al. Pre-activation timing determines influenza severity and viral pathogenicity via STING Inhibition. Sci Rep 15, 44501 (2025).  Abstract  
submitted by kickingbird at Dec, 28, 2025 from Sci Rep 15, 44501 (2025) (via https://www.nature.com/articles/s41598-025-28063-w)
Severe influenza is frequently associated with bacterial or viral co-infections. Although immune-mediated mechanisms have been extensively investigated, the cell-intrinsic responses of respiratory epithelial ...

Yang G, Chen P-L, Rovito SW, Minari K, Writt HN, D. Resistance Mutations to Broadly Neutralizing Antibodies Destabilize Hemagglutinin and Attenuate H1N1 Influenza Virus. Viruses. 2026; 18(1):32.  Abstract  
submitted by kickingbird at Dec, 25, 2025 from Viruses. 2026; 18(1):32 (via https://www.mdpi.com/1999-4915/18/1/32)
Because antigenic drift primarily generates amino-acid changes in the membrane-distal hemagglutinin (HA) head, broadly neutralizing antibodies (bNAbs) are being developed to target conserved epitopes in ...

Panova, A.S., Gudymo, A.S., Kolosova, N.P. et al. Genotype A3 influenza A(H5N1) isolated from fur seals shows high virulence in mammals, but not airborne transmission. Sci Rep 15, 44463 (2025).  Abstract  
submitted by kickingbird at Dec, 25, 2025 from Sci Rep 15, 44463 (2025) (via https://link.springer.com/article/10.1038/s41598-025-28032-3)
The global spread of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses has recently extended to include diverse mammalian species, raising new concerns about pandemic risk. In 2023, this ...

Mengdi Guan, etc.,al. Genetic diversity of H13 avian influenza viruses in migratory shorebirds in eastern China. Journal of Integrative Agriculture.  Abstract  
submitted by kickingbird at Dec, 25, 2025 from Journal of Integrative Agriculture (via https://www.sciencedirect.com/science/article/pii/S209531192)
Highlights1.Twenty one H13 subtype avian influenza viruses were isolated from 50016 samples in migratory birds during 2017 to 2024 in Shandong Province, China2.The H13 viruses were mainly harbored by shorebirds ...

Epidemic and Pandemic Preparedness and Prevention. Stockpiling of medical countermeasures for pandemic influenza: considerations brief. WHO.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from WHO (via https://www.who.int/publications/i/item/9789240117860)
This document provides a comprehensive, risk-informed framework to support countries in assessing, designing, and managing medical countermeasure (MCM) stockpiles for pandemic influenza and related respiratory ...

Epidemic and Pandemic Preparedness and Prevention. Planning for national allocations of pandemic influenza medical countermeasures: considerations brief. WHO.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from WHO (via https://www.who.int/publications/i/item/9789240117884)
This document presents comprehensive, ethics-based considerations to guide national decisions on allocating pandemic products such as vaccines, therapeutics, and diagnostics. Drawing on lessons from past ...

Alvin Crespo-Bellido, etc.,al. [preprint]Emergence of D1.1 reassortant H5N1 avian influenza viruses in North America. https://doi.org/10.64898/2025.12.19.695329.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from https://doi.org/10.64898/2025.12.19.695329 (via https://www.biorxiv.org/content/10.64898/2025.12.19.695329v1)
Since 2021, highly pathogenic avian influenza viruses (HPAIV) belonging to H5N1 clade 2.3.4.4b have caused high mortality in North American wild birds and poultry. In 2025, a new D1.1 genotype caused two ...

Shen M, Yu J, Fu B, Yu C, Cui C, Chen S, et al. Influenza D Virus in Black Donkeys, Northern China. Emerg Infect Dis. 2025 Dec.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from Emerg Infect Dis. 2025 Dec (via https://wwwnc.cdc.gov/eid/article/31/12/25-0666_article)
Influenza D virus (IDV) is prevalent in cattle in China, and a risk for spillover to other species exists. We detected IDV antibodies in 6/315 of black donkeys in northern China, suggesting cattle-to-donkey ...

Hatta Y, De La Cruz J, Murray T, Hiatt B, Jang Y,. Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Poultry Farm Workers, Washington, USA, 2024. Emerg Infect Dis. 2025 Dec.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from Emerg Infect Dis. 2025 Dec (via https://wwwnc.cdc.gov/eid/article/31/12/25-1118_article)
Poultry workers in Washington, USA, were infected with highly pathogenic avian influenza A(H5N1) virus and recovered. The viruses were clade 2.3.4.4b genotype D1.1, closely related to viruses causing poultry ...

Song Y, Yan A, Song S, Gong H, Chen L, Fu B, Zhang. Phylogenetic Analyses and Biological Characterization of H9N2 Avian Influenza Virus Isolated from Chickens in China from 2022 to 2023. Microorganisms. 2026; 14(1):37.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from Microorganisms. 2026; 14(1):37 (via https://www.mdpi.com/2076-2607/14/1/37)
The continued diversification of the H9N2 avian influenza virus (AIV) into multiple antigenically and phylogenetically distinct lineages is promoting the emergence of strains with pandemic potential. Constant ...

Schmierer J, Lutz M, Takimoto T. 0. Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations. J Virol 0:e01391-25.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from J Virol 0:e01391-25 (via https://journals.asm.org/doi/10.1128/jvi.01391-25)
The 2009 pandemic H1N1 (pH1N1) influenza A virus (IAV) is a reassortant virus with two polymerase components, PA and PB2, originating from avian IAV. Avian IAV polymerase does not function efficiently ...

Jeffery D. Sullivan, etc.,al. Rapid increase in antibodies to influenza A virus H5 and N1 in Lesser Scaup (Aythya affinis) following the introduction of 2.3.4.4b H5N1 into North America. Canadian Journal of Microbiology.  Abstract  
submitted by kickingbird at Dec, 24, 2025 from Canadian Journal of Microbiology (via https://www.sciencedirect.com/org/science/article/pii/S00084)
Clade 2.3.4.4b Eurasian-origin H5N1 entered North America in late 2021 and spread across the continent. While studies have characterized the antibody response mounted by dabbling ducks following exposure, ...

Shu Zhou, Rute Maria Pinto, Hou Wei Chook, Eleanor. [preprint]Identification of cis-Acting Elements that Regulate Influenza A Virus Segment 7 Differential mRNA Splicing. https://doi.org/10.64898/2025.12.22.695654.  Abstract  
submitted by kickingbird at Dec, 23, 2025 from https://doi.org/10.64898/2025.12.22.695654 (via https://www.biorxiv.org/content/10.64898/2025.12.22.695654v1)
Influenza A virus segment 7 encodes the M1 matrix protein and M2 ion channel from an unspliced primary transcript mRNA1 and spliced mRNA2, respectively. Both proteins are essential for efficient virus ...

Gabriela J. Rzeszutek, etc.,al. [preprint]Zoonotic and Avian Pathogen Detections in Fecal and Sediment Samples - A Low-risk, High-throughput One Health Approach to Surveillance. https://doi.org/10.64898/2025.12.19.694637.  Abstract  
submitted by kickingbird at Dec, 23, 2025 from https://doi.org/10.64898/2025.12.19.694637 (via https://www.biorxiv.org/content/10.64898/2025.12.19.694637v1)
Many pathogens, both those with human spillover potential as well as avian-specific viruses, are maintained in wild bird populations. While much surveillance for influenza A viruses (IAVs) is performed ...

Niel KR, St Charles KM, Elissa JY, Lighty ME, Ssem. Highly Pathogenic Avian Influenza (HPAI H5N1, Clade 2.3.4.4b, genotype C2.1) in Commercial Ring-Necked Pheasants During the 2022 Outbreak in the United States. Can J Microbiol. 2025 Dec 22.  Abstract  
submitted by kickingbird at Dec, 23, 2025 from Can J Microbiol. 2025 Dec 22 (via https://cdnsciencepub.com/doi/10.1139/cjm-2025-0198)
Highly pathogenic avian influenza (HPAI) virus H5N1 clade 2.3.4.4b was introduced into North America in 2021. In 2022, clade 2.3.4.4b spilled into domestic poultry in the United States (U.S.), resulting ...

St Charles KM, Ssematimba A, Bonney P, Cardona C. Evaluation of transmission metrics in a slow-spreading highly pathogenic avian influenza (HPAI) outbreak in a commercial upland game bird system. Can J Microbiol. 2025 Dec 22.  Abstract  
submitted by kickingbird at Dec, 23, 2025 from Can J Microbiol. 2025 Dec 22 (via https://cdnsciencepub.com/doi/10.1139/cjm-2025-0203)
In 2022, highly pathogenic avian influenza virus (HPAIV) H5N1 clade 2.3.4.4b was detected in United States (US) poultry, quickly escalating into an outbreak that surpassed the 2014/15 HPAI US event in ...

Wang G, Gao X, Zhang G, Deng G, Shi J. Replication and Transmission of Influenza A Virus in Farmed Mink. Viruses. 2026; 18(1):9.  Abstract  
submitted by kickingbird at Dec, 22, 2025 from Viruses. 2026; 18(1):9 (via https://www.mdpi.com/1999-4915/18/1/9)
Farmed mink are frequently exposed to circulating influenza A viruses (IAVs), as confirmed by viral isolation and serological evidence. Previous work reveals that na?ve mink serve as susceptible hosts ...

Song Y, Song S, Yan A, Gong H, Yang H, Guan F, Zha. A Novel Recombinant Chicken-Derived H6N8 Subtype Avian Influenza Virus Caused Disease in Chickens and Mice. Viruses. 2026; 18(1):12.  Abstract  
submitted by kickingbird at Dec, 22, 2025 from Viruses. 2026; 18(1):12 (via https://www.mdpi.com/1999-4915/18/1/12)
H6 subtype avian influenza viruses (AIVs) have a broader host range and circulate globally in wild birds, domestic ducks, geese, and terrestrial poultry all over the world. Their demonstrated capacity ...

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