Jang SG, Kim YI, Casel MAB, Choi JH, Gil JR, Rollo. HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts. Emerg Microbes Infect. 2024 Jan 8:2302854. Abstract
submitted by kickingbird at Jan, 9, 2024 from Emerg Microbes Infect. 2024 Jan 8:2302854 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2024.2)
During the 2021/2022 winter season, we isolated highly pathogenic avian influenza (HPAI) H5N1 viruses harboring an amino acid substitution from Asparagine(N) to Aspartic acid (D) at residue 193 of the ... Wang Q, Liu Z, Zeng X, Zheng Y, Lan L, Wang X, Lai. Integrated analysis of miRNA-mRNA expression of newly emerging swine H3N2 influenza virus cross-species infection with tree shrews. Virol J. 2024 Jan 4;21(1):4. Abstract
submitted by kickingbird at Jan, 5, 2024 from Virol J. 2024 Jan 4;21(1):4 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Background: Cross-species transmission of zoonotic IAVs to humans is potentially widespread and lethal, posing a great threat to human health, and their cross-species transmission mechanism has attracted ... Elli S, Raffaini G, Guerrini M, Kosakovsky Pond S,. Molecular modeling and phylogenetic analyses highlight the role of amino acid 347 of the N1 subtype neuraminidase in influenza virus host range and interspecies adaptation. Front Microbiol. 2023 Dec 19;14:1309156. Abstract
submitted by kickingbird at Jan, 5, 2024 from Front Microbiol. 2023 Dec 19;14:1309156 (via https://www.frontiersin.org/articles/10.3389/fmicb.2023.1309)
The N1 neuraminidases (NAs) of avian and pandemic human influenza viruses contain tyrosine and asparagine, respectively, at position 347 on the rim of the catalytic site; the biological significance of ... Nu?ez IA, Jang H, Huang Y, Kelvin A, Ross TM. Influenza virus immune imprinting dictates the clinical outcomes in ferrets challenged with highly pathogenic avian influenza virus H5N1. Front Vet Sci. 2023 Dec 19;10:1286758. Abstract
submitted by kickingbird at Jan, 5, 2024 from Front Vet Sci. 2023 Dec 19;10:1286758 (via https://www.frontiersin.org/articles/10.3389/fvets.2023.1286)
Zoonotic transmission of H5N1 highly pathogenic avian influenza virus (HPAIV) into the human population is an increasing global threat. The recent 2022 HPAIV outbreak significantly highlighted this possibility, ... Hohensee L, Scheibner D, Sch?fer A, Shelton H, Met. The role of PB1-F2 in adaptation of high pathogenicity avian influenza virus H7N7 in chickens. Vet Res. 2024 Jan 3;55(1):5. Abstract
submitted by kickingbird at Jan, 5, 2024 from Vet Res. 2024 Jan 3;55(1):5 (via https://veterinaryresearch.biomedcentral.com/articles/10.118)
Avian influenza viruses (AIV) of the H7N7 subtype are enzootic in the wild bird reservoir in Europe, cause infections in poultry, and have sporadically infected humans. The non-structural protein PB1-F2 ... El-Kafrawy SA, Alsayed SM, Faizo AA, Bajrai LH, Ut. Genetic diversity and molecular analysis of human influenza virus among pilgrims during Hajj. Heliyon. 2023 Dec 2;10(1):e23027. Abstract
submitted by kickingbird at Jan, 3, 2024 from Heliyon. 2023 Dec 2;10(1):e23027 (via https://www.cell.com/heliyon/fulltext/S2405-8440(23)10235-0)
The risk of transmission of respiratory tract infections is considerably enhanced at mass gathering (MG) religious events. Hajj is an annual Islamic MG event with approximately 3 million Muslim pilgrims ... Li H, Sun Z, Zheng T, Chen M, Lei X, Yu X, Ning Z. CD46 inhibits the replication of swine influenza viruses by promoting the production of type I IFNs in PK-15 cells. Vet Res Commun. 2023 Dec 28. Abstract
submitted by kickingbird at Dec, 29, 2023 from Vet Res Commun. 2023 Dec 28 (via https://link.springer.com/article/10.1007/s11259-023-10289-6)
Swine flu caused by swine influenza A virus (swIAV) is an acute respiratory viral disease that is spreading in swine herds worldwide. Although the effect of some host factors on replication of swIAV has ... Rashid F, Xie Z, Li M, Xie Z, Luo S, Xie L. Roles and functions of IAV proteins in host immune evasion. Front Immunol. 2023 Dec 13;14:1323560. Abstract
submitted by kickingbird at Dec, 28, 2023 from Front Immunol. 2023 Dec 13;14:1323560 (via https://www.frontiersin.org/articles/10.3389/fimmu.2023.1323)
Influenza A viruses (IAVs) evade the immune system of the host by several regulatory mechanisms. Their genomes consist of eight single-stranded segments, including nonstructural proteins (NS), basic polymerase ... Finney J, Moseman AP, Kong S, Watanabe A, Song S,. Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e23169. Abstract
submitted by kickingbird at Dec, 27, 2023 from Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e23169 (via https://www.pnas.org/doi/10.1073/pnas.2316964120)
Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV ... Daulagala P, Cheng SMS, Chin A, Luk LLH, Leung K,. Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09. Emerg Infect Dis. 2024 Jan;30(1):168-171. Abstract
submitted by kickingbird at Dec, 27, 2023 from Emerg Infect Dis. 2024 Jan;30(1):168-171 (via https://wwwnc.cdc.gov/eid/article/30/1/23-0756_article)
We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, ... Kristensen C, Larsen LE, Trebbien R, Jensen HE. The avian influenza A virus receptor SA-α2,3-Gal is expressed in the porcine nasal mucosa sustaining the pig as a mixing vessel for new influenza viruses. Virus Res. 2023 Dec 22:199304. Abstract
submitted by kickingbird at Dec, 25, 2023 from Virus Res. 2023 Dec 22:199304 (via https://pubmed.ncbi.nlm.nih.gov/38142890/)
Influenza A viruses (IAVs) originate from wild birds but have on several occasions jumped host barriers and are now also circulating in humans and mammals. The IAV host receptors (glycans with galactose ... Lean FZX, Falchieri M, Furman N, Tyler G, Robinson. Highly pathogenic avian influenza virus H5N1 infection in skua and gulls in the United Kingdom, 2022. Vet Pathol. 2023 Dec 23:3009858231217224. Abstract
submitted by kickingbird at Dec, 25, 2023 from Vet Pathol. 2023 Dec 23:3009858231217224 (via https://journals.sagepub.com/doi/10.1177/03009858231217224)
The reemergence of the highly pathogenic avian influenza virus (HPAIV) subtype H5N1 in the United Kingdom in 2021-2022 has caused unprecedented epizootic events in wild birds and poultry. During the summer ... Hickerson BT, Huang BK, Petrovskaya SN, Ilyushina. Genomic Analysis of Influenza A and B Viruses Carrying Baloxavir Resistance-Associated Substitutions Serially Passaged in Human Epithelial Cells. Viruses. 2023 Dec 16;15(12):2446. Abstract
submitted by kickingbird at Dec, 25, 2023 from Viruses. 2023 Dec 16;15(12):2446 (via https://www.mdpi.com/1999-4915/15/12/2446)
Baloxavir marboxil (baloxavir) is an FDA-approved inhibitor of the influenza virus polymerase acidic (PA) protein. Here, we used next-generation sequencing to compare the genomic mutational profiles of ... Wu R, Zeng X, Wu M, Xie L, Xu G, Mao Y, Wang Z, Ch. The Mobility of Eurasian Avian-like M2 Is Determined by Residue E79 Which Is Essential for Pathogenicity of 2009 Pandemic H1N1 Influenza Virus in Mice. Viruses. 2023 Nov 30;15(12):2365. Abstract
submitted by kickingbird at Dec, 25, 2023 from Viruses. 2023 Nov 30;15(12):2365 (via https://www.mdpi.com/1999-4915/15/12/2365)
In 2009, a novel H1N1 influenza virus caused the first influenza pandemic of the 21st century. Studies have shown that the influenza M gene played important roles in the pathogenicity and transmissibility ... Arbani O, Ducatez MF, Mahmoudi S, Salamat F, Khayi. Low Pathogenic Avian Influenza H9N2 Viruses in Morocco: Antigenic and Molecular Evolution from 2021 to 2023. Viruses. 2023 Nov 30;15(12):2355. Abstract
submitted by kickingbird at Dec, 25, 2023 from Viruses. 2023 Nov 30;15(12):2355 (via https://www.mdpi.com/1999-4915/15/12/2355)
Avian influenza viruses pose significant threats to both the poultry industry and public health worldwide. Among them, the H9N2 subtype has gained substantial attention due to its high prevalence, especially ... Sakuma S, Tanikawa T, Tsunekuni R, Mine J, Kumagai. Experimental Infection of Chickens with H5N8 High Pathogenicity Avian Influenza Viruses Isolated in Japan in the Winter of 2020-2021. Viruses. 2023 Nov 23;15(12):2293. Abstract
submitted by kickingbird at Dec, 25, 2023 from Viruses. 2023 Nov 23;15(12):2293 (via https://www.mdpi.com/1999-4915/15/12/2293)
During the winter of 2020-2021, numerous outbreaks of high pathogenicity avian influenza (HPAI) were caused by viruses of the subtype H5N8 in poultry over a wide region in Japan. The virus can be divided ... Sun X, Belser JA, Pulit-Penaloza JA, Brock N, Kier. A naturally occurring HA-stabilizing amino acid (HA1-Y17) in an A(H9N2) low-pathogenic influenza virus contributes to airborne transmission. mBio. 2023 Dec 19:e0295723. Abstract
submitted by kickingbird at Dec, 20, 2023 from mBio. 2023 Dec 19:e0295723 (via https://journals.asm.org/doi/10.1128/mbio.02957-23)
Despite the accumulation of evidence showing that airborne transmissible influenza A virus (IAV) typically has a lower pH threshold for hemagglutinin (HA) fusion activation, the underlying mechanism for ... Hu J, Zeng Z, Chen X, Zhang M, Hu Z, Gu M, Wang X,. Phosphorylation of PB2 at serine 181 restricts viral replication and virulence of the highly pathogenic H5N1 avian influenza virus in mice. Virol Sin. 2023 Dec 14:S1995-820X(23)00155-4. Abstract
submitted by kickingbird at Dec, 18, 2023 from Virol Sin. 2023 Dec 14:S1995-820X(23)00155-4 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza A virus (IAV) still poses a pandemic threat to public health, causing a high mortality rate annually and during pandemic years. Posttranslational modification of the viral protein plays a substantial ... Chenavier F, Estrozi LF, Teulon JM, Zarkadas E, Fr. Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation. Sci Adv. 2023 Dec 15;9(50):eadj9974. Abstract
submitted by kickingbird at Dec, 17, 2023 from Sci Adv. 2023 Dec 15;9(50):eadj9974 (via https://www.science.org/doi/10.1126/sciadv.adj9974)
Influenza virus genome encapsidation is essential for the formation of a helical viral ribonucleoprotein (vRNP) complex composed of nucleoproteins (NP), the trimeric polymerase, and the viral genome. Although ... Dosey A, Ellis D, Boyoglu-Barnum S, Syeda H, Saund. Combinatorial immune refocusing within the influenza hemagglutinin RBD improves cross-neutralizing antibody responses. Cell Rep. 2023 Dec 13;42(12):113553. Abstract
submitted by kickingbird at Dec, 17, 2023 from Cell Rep. 2023 Dec 13;42(12):113553 (via https://www.cell.com/cell-reports/fulltext/S2211-1247(23)015)
The receptor-binding domain (RBD) of influenza virus hemagglutinin (HA) elicits potently neutralizing yet mostly strain-specific antibodies. Here, we evaluate the ability of several immunofocusing techniques ... 6895 items, 20/Page, Page[95/345][|<<] [|<] [91] [92] [93] [94] [95] [96] [97] [98] [99] [100] [>|] [>>|] |
Related Pages:
Browse by Category
Learn about the flu news, articles, events and more
Subscribe to the weekly F.I.C newsletter!
|
- 
