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2026-3-18 9:13:14
Article

Nazia N, Pullenayegum E, Loeb M. Individual and Environmental Factors Influencing Influenza Transmission: A Multilevel Analysis. Influenza Other Respir Viruses. 2026 Feb;20(2):e70.  Abstract  
submitted by kickingbird at Feb, 5, 2026 from Influenza Other Respir Viruses. 2026 Feb;20(2):e70 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70232)
Background: Influenza transmission is influenced by both individual characteristics and community-level drivers. Understanding how these drivers jointly influence transmission is important to predicting ...

Zhao L, Wang J, Xu J, Guo J, Zhang P, Guo X, Zuo Z. Surveillance reveals a prevalent pediatric A(H1N1)pdm09 virus with hemagglutinin substitutions S137P-R142K-V152I that diminish vaccine efficacy. Virus Genes. 2026 Feb 4.  Abstract  
submitted by kickingbird at Feb, 5, 2026 from Virus Genes. 2026 Feb 4 (via https://link.springer.com/article/10.1007/s11262-026-02218-x)
Influenza A(H1N1)pdm09 viruses pose a significant disease burden on children worldwide, with high rates of hospitalization and substantial morbidity and mortality. Outpatient < 18 years of age with upper ...

Ma, J., Wang, YH., Qiu, YB. et al. A global dataset of spatiotemporal co-occurrence patterns of avian influenza virus-associated migratory birds. Sci Data (2026).  Abstract  
submitted by kickingbird at Feb, 4, 2026 from Sci Data (2026) (via https://link.springer.com/article/10.1038/s41597-026-06701-w)
Migratory birds facilitate the cross-regional spread of pathogens such as avian influenza virus (AIV). Interspecies interactions among multiple migratory bird species within shared spatiotemporal habitats ...

Mkpuma N, Meseko C, Shittu I, Chukwu C, Afiukwa FN. Molecular characterization and phylogeography of equine influenza virus H3N8 detected in donkeys in Nigeria 2022-2023. BMC Vet Res. 2026 Feb 3.  Abstract  
submitted by kickingbird at Feb, 4, 2026 from BMC Vet Res. 2026 Feb 3 (via https://link.springer.com/article/10.1186/s12917-025-05279-6)
Background: Equine influenza virus (EIV) H3N8 is a highly contagious respiratory pathogen that poses significant health and economic risks to equids globally. In southeastern Nigeria where equids are sold ...

Yang Y, Xu M, Zhang N, Yu Q, Wan Y, Xu C, Wu Y, Me. PA-X 122V broadly determines the host shutoff activity of influenza A viruses. mBio 0:e03433-25.  Abstract  
submitted by kickingbird at Feb, 3, 2026 from mBio 0:e03433-25 (via https://journals.asm.org/doi/10.1128/mbio.03433-25)
Multiple genes are involved in the pathogenicity of influenza A virus. Our previous study reported two naturally occurring amino acid mutations in the polymerase acidic (PA) protein as crucial determinants ...

Ling Tang, Rui Wang, Guimei He. Molecular Characteristics and Genetic Evolution of H1N1 Avian Influenza Virus from Wild birds in Shanghai, China. Poultry Science.  Abstract  
submitted by kickingbird at Feb, 3, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H1N1 influenza virus is a major pandemic and seasonal pathogen with a broad host range, posing a substantial threat to human health and underscoring the need for continuous surveillance. Wild birds, ...

Xia, Y., Farrukee, R., Brooks, A.G. et al. Host restriction factor SAMHD1 does not restrict seasonal influenza virus replication in human epithelial or macrophage-like cells. Virol J (2026).  Abstract  
submitted by kickingbird at Feb, 2, 2026 from Virol J (2026) (via https://link.springer.com/article/10.1186/s12985-026-03065-w)
BackgroundSAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase protein 1 (SAMHD1) is an intracellular protein that regulates a stable deoxynucleoside triphosphates (dNTPs) for ...

Hu J, Li J, Li Q, Jiang S, Cao Z, Chen H. Enhancing the stability of Influenza A reporter viruses by recoding the gfp gene. Virol Sin. 2026 Jan 29:S1995-820X(26)00011-8.  Abstract  
submitted by kickingbird at Feb, 2, 2026 from Virol Sin. 2026 Jan 29:S1995-820X(26)00011-8 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza A virus (IAV) is one of the most important zoonotic pathogens and can cause global influenza pandemics and seasonal influenza outbreaks. Generation of recombinant IAV expressing a fluorescent ...

Yang Xue, Yuki Tai, Hiromi Yamamoto, Daiki Mori, K. T cell help is a limiting factor for rare anti-influenza memory B cells to reenter germinal centers and generate potent broadly neutralizing antibodies. International Immunology, 2026;, dxag003.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from International Immunology, 2026;, dxag003 (via https://academic.oup.com/intimm/advance-article-abstract/doi)
Development of vaccines eliciting broadly neutralizing influenza antibodies (bnAbs) is an extraordinary challenge. One hypothetical proposal is that CD4+ T cell help to rare immuno-subdominant bnAb class ...

Andrew Y Cho, Dong-Hun Lee, Alice Fusaro, Edoardo. Wild birds drive the introduction, maintenance, and spread of H5N1 clade 2.3.4.4b high pathogenicity avian influenza viruses in Spain, 2021-2022. Virus Evolution, 2026;, veag006.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Virus Evolution, 2026;, veag006 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
The 2021-2022 high pathogenicity avian influenza (HPAI) epizootic was the worst ever recorded in Europe in general and in Spain in particular. Between December 2021 and November 2022, H5N1 clade 2.3.4.4b ...

Xingyi Li, etc.,al. [preprint]FluNexus: a versatile web platform for antigenic prediction and visualization of influenza A viruses. https://doi.org/10.64898/2026.01.29.702696.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from https://doi.org/10.64898/2026.01.29.702696 (via https://www.biorxiv.org/content/10.64898/2026.01.29.702696v1)
Influenza A viruses continuously undergo antigenic evolution to escape host immunity induced by previous infections or vaccinations, consequently causing seasonal epidemics and occasional pandemics. Antigenic ...

Ying, Baoling et al. An intranasal adenoviral-vectored vaccine protects against highly pathogenic avian influenza H5N1 in naive and antigen-experienced animals. Cell Reports Medicine, January 30, 2026.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Cell Reports Medicine, January 30, 2026 (via https://www.cell.com/cell-reports-medicine/fulltext/S2666-37)
The emergence of highly pathogenic avian H5N1 influenza viruses in dairy cows and humans has increased the potential for another pandemic. To address this risk, we developed chimpanzee adenoviral (ChAd)-vectored ...

Daniel, Katharina et al. Pre-existing neutralizing antibodies against cattle-transmitted influenza A virus H5N1 are detectable in unexposed individuals. Immunity, January 30, 2026.  Abstract  
submitted by kickingbird at Jan, 31, 2026 from Immunity, January 30, 2026 (via https://www.cell.com/immunity/fulltext/S1074-7613(25)00569-2)
The transmission of influenza A virus H5N1 clade 2.3.4.4b from cattle to humans highlights the risk of an H5N1 pandemic. Pre-existing immunity strongly impacts the course and severity of viral infections, ...

Xiaolong Lu, etc.,al. The host RNA helicase DDX6 restricts avian influenza virus replication by targeting viral NP and modulating ISG15. Poultry Science.  Abstract  
submitted by kickingbird at Jan, 30, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H7N9 subtype of avian influenza virus (AIV) poses a significant and ongoing threat to public health. As a critical structural and functional component, the viral nucleoprotein (NP) is abundantly expressed ...

Kieran Dee, etc.,al. [preprint]Subclade K influenza A (H3N2) viruses display partial immune escape with preserved cross-neutralisation in a UK population. https://doi.org/10.64898/2026.01.27.26344933.  Abstract  
submitted by kickingbird at Jan, 30, 2026 from https://doi.org/10.64898/2026.01.27.26344933 (via https://www.medrxiv.org/content/10.64898/2026.01.27.26344933)
We examined whether the recent emergence of influenza A(H3N2) subclade K, associated with an unusually early influenza season in the Northern hemisphere, was accompanied by a reduction in human population ...

Kong H, Yang J, Shi J, Cui P, Zeng X, Liu W, He X,. Protective Efficacy of a Hemagglutinin-Based mRNA Vaccine Against H5N1 Influenza Virus Challenge in Lactating Dairy Cows. Research (Wash D C). 2026 Jan 26;9:1104.  Abstract  
submitted by kickingbird at Jan, 29, 2026 from Research (Wash D C). 2026 Jan 26;9:1104 (via https://spj.science.org/doi/10.34133/research.1104)
Highly pathogenic avian influenza H5N1 virus has spread to over 1,080 dairy farms across 18 states in the United States, resulting in 41 human infections and posing serious risks to both animal and public ...

Ye, Y., Shuai, H., Song, Y. et al. Genomic features associated with sustained mammalian transmission of avian influenza A viruses. Nat Microbiol (2026).  Abstract  
submitted by kickingbird at Jan, 28, 2026 from Nat Microbiol (2026) (via https://link.springer.com/article/10.1038/s41564-025-02257-4)
Comparably few lineages of influenza A virus (IAV) have evolved long-term sustained transmission in mammals. The reasons remain largely unknown, and the possibility of avian IAVs evolving sustained mammalian ...

Zorian T Thornton, etc.,al. [preprint]antigen-prime: Simulating coupled genetic and antigenic evolution of influenza virus. https://doi.org/10.64898/2026.01.23.701420.  Abstract  
submitted by kickingbird at Jan, 27, 2026 from https://doi.org/10.64898/2026.01.23.701420 (via https://www.biorxiv.org/content/10.64898/2026.01.23.701420v1)
Seasonal influenza virus undergoes rapid antigenic drift to escape population immunity. Computational methods can be used to organize viral genetic diversity into antigenically similar variants and estimate ...

Belser, J.A., Brock, N., Sun, X. et al. Oseltamivir and baloxavir monotherapy and combination therapy efficacy against clade 2.3.4.4b A(H5N1) influenza virus infection in ferrets. Commun Biol (2026).  Abstract  
submitted by kickingbird at Jan, 27, 2026 from Commun Biol (2026) (via https://link.springer.com/article/10.1038/s42003-026-09607-w)
Neuraminidase inhibitors (NAIs) and cap-dependent endonuclease inhibitors (CENIs) represent two classes of antiviral drugs recommended for early treatment of patients with seasonal influenza A virus (IAV) ...

Arata Hidano, etc.,al. Epidemiology and Risk Modelling of Influenza A Virus Within and Between Pig Herds in Northern Lao PDR. Transboundary and Emerging Diseases.  Abstract  
submitted by kickingbird at Jan, 26, 2026 from Transboundary and Emerging Diseases (via https://onlinelibrary.wiley.com/doi/10.1155/tbed/2407533)
Animal-origin influenza A virus (IAV) is a perennial candidate for causing the next pandemic. With high risk for interspecies IAV transmission but limited resources for surveillance, particularly in rural ...

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