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2026-5-31 20:54:45
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Munguía-Ramírez B, Armenta-Leyva B, Giménez-Lirola. Pilot Assessment of RNA Stabilization Methods for Influenza A Virus in Swine Oral Fluids. Pathogens. 2026; 15(4):439.  Abstract  
submitted by kickingbird at Apr, 21, 2026 from Pathogens. 2026; 15(4):439 (via https://www.mdpi.com/2076-0817/15/4/439)
Influenza A Virus (IAV) surveillance in swine relies heavily on molecular detection, yet RNA stability in diagnostic specimens such as oral fluids can be rapidly compromised when cold-chain conditions ...

Benavides, F.F.W., Kempff, A.L.V., Smeenk, H. et a. Influenza A virus infection impairs neuronal activity in human iPSC-derived NGN2 neural co-cultures. acta neuropathol commun (2026).  Abstract  
submitted by kickingbird at Apr, 21, 2026 from acta neuropathol commun (2026) (via https://link.springer.com/article/10.1186/s40478-026-02292-0)
Influenza A virus (IAV) infection is associated with a wide variety of neurological complications, of which mild complications like impaired cognitive functioning are most prominent. Even though several ...

Cargnin Faccin, F., Gay, L.C., Regmi, D. et al. Experimental infection and viral pathogenesis of a human isolate of H5N1 highly pathogenic avian influenza strain in Jersey cows. npj Vet. Sci. 1, 2 (2026).  Abstract  
submitted by kickingbird at Apr, 21, 2026 from npj Vet. Sci. 1, 2 (2026) (via https://www.nature.com/articles/s44433-025-00002-5)
Highly pathogenic avian influenza H5N1 viruses have circulated globally since 1996. In recent years, clade 2.3.4.4b H5N1 viruses have crossed the species barrier into multiple species, including dairy ...

Lambodhar Damodaran, etc.,al. [preprint]Frequent seasonal reassortment between high and low path viruses drives the diversification of influenza A/H5N1. https://doi.org/10.64898/2026.04.17.719307.  Abstract  
submitted by kickingbird at Apr, 21, 2026 from https://doi.org/10.64898/2026.04.17.719307 (via https://www.biorxiv.org/content/10.64898/2026.04.17.719307v1)
Since 2021, highly pathogenic (HPAI) H5N1 viruses have spread across the Americas, diversifying via reassortment into new genotypes that have spilled into humans and livestock, raising fears of a new influenza ...

Chloe Fontane, etc.,al. [preprint]Ocular findings in Northern Gannets following an outbreak of high pathogenicity avian influenza (H5N1). https://doi.org/10.64898/2026.04.15.718625.  Abstract  
submitted by kickingbird at Apr, 21, 2026 from https://doi.org/10.64898/2026.04.15.718625 (via https://www.biorxiv.org/content/10.64898/2026.04.15.718625v1)
During 2021-2022, high pathogenicity avian influenza (HPAI) caused mass mortality in wild birds across Europe, with Northern Gannets (Morus bassanus) among the most affected. Following the outbreak, unusual ...

Tarrés-Freixas F, Ceada G, Català-Moll F, Casadell. Airway organoids reveal patterns of influenza A tropism and adaptation in wildlife species. Emerg Microbes Infect. 2026 Dec;15(1):2654273.  Abstract  
submitted by kickingbird at Apr, 19, 2026 from Emerg Microbes Infect. 2026 Dec;15(1):2654273 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
Identifying animal species that are susceptible to the plethora of existing and emerging viruses is critical for predicting and containing disease outbreaks. Current efforts to assess viral tropism largely ...

Valdez-May MJ, Nofrarías M, Pina-Pedrero S, Dabad. Early nasal and lung transcriptomic profiles reveal pathways associated with divergent clinical outcomes following H7N1 high pathogenicity avian influenza virus infection. Poult Sci. 2026 Mar 20;105(7):106833.  Abstract  
submitted by kickingbird at Apr, 19, 2026 from Poult Sci. 2026 Mar 20;105(7):106833 (via https://www.sciencedirect.com/science/article/pii/S003257912)
High pathogenicity avian influenza (HPAI) devastates the poultry industry worldwide due to its rapid spread, severe pathology, and high mortality in chickens. Why some infected birds survive while others ...

Maria Rios Carrasco, etc.,al. [preprint]Acquisition of specific human respiratory tract binding of 2.3.4.4b H5N1 hemagglutinins requires multiple mutations. https://doi.org/10.64898/2026.04.16.718875.  Abstract  
submitted by kickingbird at Apr, 19, 2026 from https://doi.org/10.64898/2026.04.16.718875 (via https://www.biorxiv.org/content/10.64898/2026.04.16.718875v1)
It has been suggested that the hemagglutinin of the human-infecting cattle-derived 2.3.4.4b virus A/Texas/34 (H5TX) requires only one mutation, namely Q226L, to switch from binding avian-type to human-type ...

Rebecca A Ross, etc.,al. [preprint]Infection of the bovine mammary gland by avian H5N1 subclade 2.3.4.4b influenza viruses. https://doi.org/10.64898/2026.04.16.718897.  Abstract  
submitted by kickingbird at Apr, 19, 2026 from https://doi.org/10.64898/2026.04.16.718897 (via https://www.biorxiv.org/content/10.64898/2026.04.16.718897v1)
The emergence of the panzootic clade of highly pathogenic avian influenza H5N1 (2.3.4.4b) in 2020 marked a major expansion in the host range of influenza A viruses (IAVs), raising concerns about further ...

Deng L, Shah T, Wang Y, Cheng P, Kui Y, Wang B, Xi. Characterization and Genetic Evolution of H6N2 Subtype AIV Isolates from Aquatic Birds. Microorganisms. 2026; 14(4):895.  Abstract  
submitted by kickingbird at Apr, 17, 2026 from Microorganisms. 2026; 14(4):895 (via https://www.mdpi.com/2076-2607/14/4/895)
Birds serve as the primary natural reservoirs for avian influenza viruses (AIVs), harboring nearly all known AIV subtypes. The seasonal migratory movements of wild birds play a significant role in the ...

Lim A, Poulsen K, Caserta LC, Guan L, Opgenorth E,. Highly Pathogenic Avian Influenza A(H5N1) Virus RNA in Bovine Semen, California, USA, 2024. Emerg Infect Dis. 2026 May.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from Emerg Infect Dis. 2026 May (via https://wwwnc.cdc.gov/eid/article/32/5/25-1639_article)
Since March 2024, highly pathogenic avian influenza (HPAI) A(H5N1) virus has infected dairy cattle in the United States, prompting concern about novel transmission routes. During an outbreak in California, ...

Harrington, W.N., Signore, A., Kercher, L. et al. Rapid expansion of genotype D1.1A(H5N1) influenza viruses in wild birds across North America during the 2024 migratory season. Nat Med (2026).  Abstract  
submitted by kickingbird at Apr, 16, 2026 from Nat Med (2026) (via https://www.nature.com/articles/s41591-026-04300-1)
In late 2021, high pathogenicity avian influenza A(H5N1) clade 2.3.4.4b viruses entered North America and reassorted rapidly with local avian influenza viruses. In September 2024, we detected a new reassortant ...

Singh G, Bhavsar D, Hermann E, Gleason C, Singh Sa. Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies. mBio 0:e00445-26.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from mBio 0:e00445-26 (via https://journals.asm.org/doi/10.1128/mbio.00445-26)
Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses continue to expand geographically and across mammalian hosts, raising concern about pandemic potential. The degree and specificity of pre-existing ...

Mark A Power, etc.,al. Characterisation of immune responses targeting highly pathogenic avian influenza A(H5) viruses in health-care workers in the Netherlands: an observational, cross-sectional analysis. The Lancet Microbe.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from The Lancet Microbe (via https://www.sciencedirect.com/science/article/pii/S266652472)
BackgroundHighly pathogenic avian influenza A(H5) viruses pose a pandemic threat, with a history of mammalian adaptation and zoonotic spillovers into humans. We aimed to determine whether pre-existing ...

Wei Zhang, etc.,al. Molecular Characterization and Pathogenicity of H9N2 Avian Influenza Viruses in Poultry in Shandong Province, China, 2021–2023. Poultry Science.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
The H9N2 avian influenza virus (AIV) is currently widespread worldwide, posing a severe threat to the poultry industry and public health. To investigate the epidemiological characteristics, genomic evolution, ...

Budt M, Barac I, Kohs J, Krischuns T, Naffakh N, W. Historical Pandemic and Contemporary Influenza A Viruses Reveal PB2 M631L as a Convergent Adaptation to Human ANP32. Microorganisms. 2026; 14(4):859.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from Microorganisms. 2026; 14(4):859 (via https://www.mdpi.com/2076-2607/14/4/859)
Understanding the genetic changes that allow avian influenza A viruses (IAVs) to switch their natural hosts and establish productive infection in humans is important for pandemic risk assessment. Adaptations ...

Branda F, Petrosillo N, Ceccarelli G, Scarpa F, Gi. Influenza A(H3N2) Subclade K (J.2.4.1): Molecular Characterization, Antigenic Divergence, and Global Spread During the 2025/26 Season. Infectious Disease Reports. 2026; 18(2):37.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from Infectious Disease Reports. 2026; 18(2):37 (via https://www.mdpi.com/2036-7449/18/2/37)
Background: Influenza A(H3N2) continues to evolve rapidly, frequently eroding population immunity and challenging seasonal vaccine strain selection. During the 2025/26 season, the A(H3N2) subclade K (J.2.4.1) ...

Ojha CR, Rovito SW, Banoth B, Kim H, Jones JC, Ala. Effect of Acid-Stabilizing Hemagglutinin Mutations on Immunogenicity and Heterologous Protection by H1N1 Influenza Virus mRNA-LNP Vaccines. Viruses. 2026; 18(4):467.  Abstract  
submitted by kickingbird at Apr, 16, 2026 from Viruses. 2026; 18(4):467 (via https://www.mdpi.com/1999-4915/18/4/467)
While current influenza vaccines often lack broad protection against antigenically drifted strains, some modified hemagglutinin (HA) protein antigens have shown promise in eliciting broadly neutralizing ...

Samuel A. Turner, David J. Pattinson, etc.,al. [preprint]Predicting the antigenic evolution of seasonal influenza viruses using phylogenetic convergence. https://doi.org/10.64898/2026.04.10.717627.  Abstract  
submitted by kickingbird at Apr, 15, 2026 from https://doi.org/10.64898/2026.04.10.717627 (via https://www.biorxiv.org/content/10.64898/2026.04.10.717627v1)
The antigenic evolution of human seasonal influenza viruses is primarily driven by single amino acid substitutions immediately adjacent to the receptor binding site in the hemagglutinin (HA) protein. The ...

Ibrahim M, Mostafa D, Manie EA, El-Sanousi AA, Sha. Field study using sentinel birds and ELISA for differentiating infected from vaccinated animals (DIVA) in chicken flocks vaccinated with inactivated avian influenza H5 vaccines. Br Poult Sci. 2026 Apr 13:1-8.  Abstract  
submitted by kickingbird at Apr, 15, 2026 from Br Poult Sci. 2026 Apr 13:1-8 (via https://www.tandfonline.com/doi/full/10.1080/00071668.2026.2)
1. This study used unvaccinated sentinels plus Avian Influenza Virus (AIV) specific ELISA for differentiating infected from vaccinated animals (DIVA). Birds assessed were from 10 broiler flocks (F1-F10), ...

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