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2025-12-5 14:44:02
Article

Lin J, Hu P, Mei G, Guo B, Wang S, Yan S, Chen JL,. Role of long non-coding RNA Lnc9101 and Lnc8475 in regulation of innate immune response to influenza virus infection. Poult Sci. 2025 Oct 4;104(12):105944.  Abstract  
submitted by kickingbird at Nov, 3, 2025 from Poult Sci. 2025 Oct 4;104(12):105944 (via https://www.sciencedirect.com/science/article/pii/S003257912)
Long non-coding RNAs (lncRNAs) are critical regulators of various biological processes, yet their roles in chicken host-virus interactions remain largely unknown. This study investigated the impact of ...

Stelfox AJ, Bessonne M, Bourhis JM, Erba EB, Alban. Monomeric structure of influenza A virus NEP/NS2 obtained with an artificial protein highlights conformational plasticity. J Mol Biol. 2025 Oct 30:169511.  Abstract  
submitted by kickingbird at Nov, 3, 2025 from J Mol Biol. 2025 Oct 30:169511 (via https://www.sciencedirect.com/science/article/abs/pii/S00222)
The influenza virus nuclear export protein (NEP)/non-structural protein 2 (NS2) is a multifunctional protein, involved in viral ribonucleoprotein export from the nucleus, genome replication enhancement, ...

Obdulio Garcia-Nicolas, etc.,al. [preprint]An RNA replicon vaccine encoding HA and NA prevents shedding of antigen-drifted 2009 pandemic H1N1 influenza virus in the pig model. https://doi.org/10.1101/2025.11.01.685547.  Abstract  
submitted by kickingbird at Nov, 3, 2025 from https://doi.org/10.1101/2025.11.01.685547 (via https://www.biorxiv.org/content/10.1101/2025.11.01.685547v1)
Seasonal influenza viruses escape the human immune response by antigenic drift, i.e. the positive selection of point mutations that prevent the binding of inhibitory antibodies to the influenza antigens ...

Jiachen Zhao, Lipeng Liu, Lili Li, Dan Wu, Chunna. Preplanned Studies: Phylogenetic and Molecular Characteristics of An H3N8 Avian Influenza Virus Detected in Wild Birds - Beijing, China, September 2024. China CDC Weekly, 2025, 7(44): 1389-1395.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from China CDC Weekly, 2025, 7(44): 1389-1395 (via https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2025)
Introduction: The H3N8 avian influenza virus (AIV) is recognized for its capacity for interspecies transmission and has been detected in multiple mammalian hosts. Between 2022 and 2023, three human infections ...

Xinyue Zhang, Xinyi Sang, Beibei Liu, Quanyu Wang,. Methods and Applications: Developing Machine Learning Prediction Model for Daily Influenza Reported Cases Using Multichannel Surveillance Data - A City, Hubei Province, China, 2023~2025. China CDC Weekly, 2025, 7(44): 1396-1402.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from China CDC Weekly, 2025, 7(44): 1396-1402 (via https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2025)
IntroductionPublic health surveillance is crucial for decision-making. Given the significant threat of influenza to public health, developing predictive models using multichannel surveillance systems is ...

Abdulgader SA, Abdulwahed AM, Almuqrin AM, Aziz IM. Genetic Divergence of H1N1pdm09 in Saudi Arabia: Unveiling a Novel N-Glycosylation Site and Its Role in Vaccine Mismatch. Vaccines. 2025; 13(11):1111.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from Vaccines. 2025; 13(11):1111 (via https://www.mdpi.com/2076-393X/13/11/1111)
Background/Objectives: Influenza A virus undergoes continuous antigenic drift, necessitating annual vaccine reformulation. Saudi Arabia faces unique epidemiological challenges owing to mass gatherings ...

Wilson A, Jauregui R, Gias E, Low YS, Little A, Jo. Phylogenetic and Molecular Characterization of a Novel Reassortant High-Pathogenicity Avian Influenza A (H7N6) Virus Detected in New Zealand Poultry. International Journal of Molecular Sciences. 2025;.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from International Journal of Molecular Sciences. 2025; (via https://www.mdpi.com/1422-0067/26/21/10623)
H7 high-pathogenicity avian influenza (HPAI) virus outbreaks can cause high rates of morbidity and mortality in poultry flocks, leading to devastating impacts on poultry industries. In December 2024, an ...

Amanda H. Seekings, etc.,al. Infection of point-of-lay hens to assess the sequential events during H7N7 high-pathogenicity avian influenza emergence at a layer premises. Virology.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from Virology (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
H7N7 low-pathogenicity avian influenza virus (H7N7-LPAIV) incursions preceded emergence of H7N7 high-pathogenicity (HP)AIV at several European layer hen outbreaks. Evidence from a UK layer H7N7-HPAIV (2008) ...

Aoxue Wang, etc.,al. The antiviral activity of interferon-stimulated genes (ISGs) in influenza A virus infection. Virology, Volume 614, February 2026, 110728.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from Virology, Volume 614, February 2026, 110728 (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
This review systematically delineates the antiviral activity of interferon-stimulated genes (ISGs) against influenza A virus (IAV) infection and their underlying mechanisms. IAV, a major respiratory pathogen, ...

Adesola, Ridwan Olamilekan, Bakre, Adetolase Aziza. Avian Influenza Screening in Captive Wild Birds and Biosecurity Appraisal of Zoological Gardens in Southwestern Nigeria. Veterinary Medicine International, 2025, 3419266.  Abstract  
submitted by kickingbird at Nov, 2, 2025 from Veterinary Medicine International, 2025, 3419266 (via https://onlinelibrary.wiley.com/doi/10.1155/vmi/3419266)
Avian influenza (AI) is a severe respiratory disease affecting wild and domestic birds globally. There is currently no approved vaccine for AI control in Nigeria. Therefore, biosecurity measures remain ...

Blondin-Brosseau M, Zhang W, Gravel C, Harlow J, L. Survival of influenza virus H1N1 and murine norovirus in raw milk cheeses. Appl Environ Microbiol. 2025 Oct 31:e0188125.  Abstract  
submitted by kickingbird at Nov, 1, 2025 from Appl Environ Microbiol. 2025 Oct 31:e0188125 (via https://journals.asm.org/doi/10.1128/aem.01881-25)
The spillover of highly pathogenic avian influenza (HPAI) to dairy cattle and its presence at high titers in raw milk has created a concern that consumption of dairy products made from unpasteurized milk ...

Pattiyakumbura TT, De Silva I, Bowatte A, Perera S. Complete genome analysis of human influenza C virus co-infection with WU polyomavirus in a Sri Lankan child: A brief report. Access Microbiol. 2025 Oct 29;7(10):000968.v3.  Abstract  
submitted by kickingbird at Nov, 1, 2025 from Access Microbiol. 2025 Oct 29;7(10):000968.v3 (via https://www.microbiologyresearch.org/content/journal/acmi/10)
Background. Influenza C virus (ICV) is a lesser known member of the Orthomyxoviridae family, primarily causing respiratory tract infections in children. Co-infection with WU polyomavirus (WUPyV), a recently ...

C. Stenkamp-Strahm, J. Lombard, B. Melody, P. Brin. [preprint]Influenza A Virus detection in Bulk Tank and Pen Level Milk from Dairies Affected by Highly Pathogenic Avian Influenza H5N1. https://doi.org/10.1101/2025.10.26.25338833.  Abstract  
submitted by kickingbird at Oct, 30, 2025 from https://doi.org/10.1101/2025.10.26.25338833 (via https://www.medrxiv.org/content/10.1101/2025.10.26.25338833v)
Highly pathogenic avian influenza virus H5N1 has been infecting dairy herds in the U.S. since its initial incursion into cows in early 2024. Although national strategies have aimed to detect affected herds, ...

Jingze Liu, etc.,al. [preprint]Deciphering the Antigenic Evolution of Seasonal Influenza A Viruses with PREDAC-Transformer: From Antigenic Clustering to Key Site Identification. https://doi.org/10.1101/2025.10.29.684974.  Abstract  
submitted by kickingbird at Oct, 30, 2025 from https://doi.org/10.1101/2025.10.29.684974 (via https://www.biorxiv.org/content/10.1101/2025.10.29.684974v1)
Seasonal influenza viruses undergo continuous antigenic drift due to mutations in the hemagglutinin (HA) protein, rendering vaccines ineffective and posing a significant global public health challenge. ...

Yo Shimazu, etc.,al. [preprint]Evaluation of therapeutic effect of baloxavir marboxil against high pathogenicity avian influenza virus infection in duck model. https://doi.org/10.1101/2025.10.24.684283.  Abstract  
submitted by kickingbird at Oct, 30, 2025 from https://doi.org/10.1101/2025.10.24.684283 (via https://www.biorxiv.org/content/10.1101/2025.10.24.684283v1)
Since 2020, high pathogenicity avian influenza virus (HPAIV) infections in wild birds have been frequently reported. Because HPAIV infection has occasionally caused outbreaks in captive rare birds, application ...

Han, X., Ma, R., Ma, X., Chen, H., Zhao, T., Liu,. Development of a broad-spectrum nasal live attenuated influenza vaccine based on mosaic antigen design against influenza B viruses. Emerging Microbes & Infections, 14(1).  Abstract  
submitted by kickingbird at Oct, 30, 2025 from Emerging Microbes & Infections, 14(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza B virus (IBV) causes significant seasonal disease burden, and frequent antigenic drift limits the effectiveness of conventional vaccines. To address this, we designed mosaic haemagglutinin (HA) ...

Fernando Capelastegui, Vidhi Dholakia, etc.,al. [preprint]An evolutionary approach to identify mammalian adaptive mutations in the avian influenza polymerase complex. https://doi.org/10.1101/2025.10.27.684835.  Abstract  
submitted by kickingbird at Oct, 29, 2025 from https://doi.org/10.1101/2025.10.27.684835 (via https://www.biorxiv.org/content/10.1101/2025.10.27.684835v1)
Avian influenza viruses (AIVs) are a global public health risk; human infection is typically associated with high mortality. While the relationship between several mammalian adaptive mutations and host ...

Sahar Mahmood, Saumya S. Thomas, etc.,al. Understanding limitations to successful avian influenza virus isolation from wild birds. Journal of Virological Methods.  Abstract  
submitted by kickingbird at Oct, 28, 2025 from Journal of Virological Methods (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
Whilst molecular methods which detect viral nucleic acid have replaced more traditional assays such as virus isolation (VI) as frontline diagnostic assays for avian influenza virus (AIV), the ability to ...

Shriver, Leah P. et al. Integrative multi-omics analysis in vivo identifies influenza virus host factors. iScience, Volume 28, Issue 11, 113644.  Abstract  
submitted by kickingbird at Oct, 28, 2025 from iScience, Volume 28, Issue 11, 113644 (via https://www.cell.com/iscience/fulltext/S2589-0042(25)01905-4)
nfluenza A virus (IAV) infection remodels cellular processes to support viral replication. The modulation of host factors by the virus drives pathogenesis during infection, and these factors may serve ...

Wang Y, Jiang L, Li Q, Li M, Shi W, et al. TRIM45 restricts influenza virus infection through modulating the chaperone-mediated autophagic degradation of viral PB2 protein. PLOS Pathogens 21(10): e1013630.  Abstract  
submitted by kickingbird at Oct, 27, 2025 from PLOS Pathogens 21(10): e1013630 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
The host defense system employs elaborate mechanisms to combat invading viruses. Here, we demonstrate that tripartite motif containing 45 (TRIM45) restricts the replication of different subtypes of influenza ...

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