Gordon C. Adams, etc.,al. [preprint]Combing the haystacks: The search for highly pathogenic avian influenza virus using a combined clinical and research-developed testing strategy. https://doi.org/10.1101/2025.02.12.25321810. Abstract submitted by kickingbird at Feb, 22, 2025 from https://doi.org/10.1101/2025.02.12.25321810 (via https://www.medrxiv.org/content/10.1101/2025.02.12.25321810v) Background Highly pathogenic H5 avian influenza A has caused sporadic human infections, increasing the risk for potential human-to-human spread. In 2024, the U.S. experienced outbreaks among poultry and ... Gonzales JE 2nd, Kim I, Bastiray A, Hwang W, Cho J. Evolutionary rewiring of the dynamic network underpinning allosteric epistasis in NS1 of the influenza A virus. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2410. Abstract submitted by kickingbird at Feb, 22, 2025 from Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2410 (via https://www.pnas.org/doi/10.1073/pnas.2410813122) Viral proteins frequently mutate to evade host innate immune responses, yet the impact of these mutations on the molecular energy landscape remains unclear. Epistasis, the intramolecular communications ... Schreiber A, Oberberg N, Ambrosy B, Rodner F, Kuma. Influenza H5Nx Viruses are susceptible to MEK1/2 Inhibition by zapnometinib. Emerg Microbes Infect. 2025 Feb 20:2471022. Abstract submitted by kickingbird at Feb, 22, 2025 from Emerg Microbes Infect. 2025 Feb 20:2471022 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2) Highly pathogenic avian influenza A viruses (HPAIV) pose a significant threat to both animal and human health. These viruses have the potential to cause severe respiratory and systemic infections in birds ... Cavicchio L, Campalto M, Carrino M, Lucchese L, Ce. Influenza in feral cat populations: insights from a study in North-East Italy. Front. Vet. Sci. 11:1439354. Abstract submitted by kickingbird at Feb, 21, 2025 from Front. Vet. Sci. 11:1439354 (via https://www.frontiersin.org/journals/veterinary-science/arti) Influenza A virus (IAV) can cause high morbidity and mortality in domestic and wild avian species and it is able to infect mammals as well. IAV in cats is sporadic and self-limiting but the recent findings ... Giovanetti M, Ali S, Slavov SN, Azarian T, Cella E. Epidemiological Transitions in Influenza Dynamics in the United States: Insights from Recent Pandemic Challenges. Microorganisms. 2025; 13(3):469. Abstract submitted by kickingbird at Feb, 21, 2025 from Microorganisms. 2025; 13(3):469 (via https://www.mdpi.com/2076-2607/13/3/469) The SARS-CoV-2 pandemic has reshaped the epidemiological landscape of respiratory diseases, with profound implications for seasonal influenza. Nonpharmaceutical interventions implemented globally during ... Huizi Li, etc.,al. Chicken C4BPM facilitates replication of H5N1 and H9N2 Avian Influenza Viruses by inhibiting the production of type I interferons. Poultry Science, Volume 104, Issue 3, March 2025. Abstract submitted by kickingbird at Feb, 21, 2025 from Poultry Science, Volume 104, Issue 3, March 2025 (via https://www.sciencedirect.com/science/article/pii/S003257912) Avian influenza viruses (AIVs) are potential pandemic of global concern, posing a major threat to both the poultry industry and human health. Host factors play a key role in the replication of AIVs, while ... Samson Oladokun, Mohammadali Alizadeh, Amirul I Ma. Influenza A Virus Subtype H9N2 Infection Induces Respiratory Microbiota Dysbiosis in Chickens via Type-I Interferon-Mediated Mechanisms. FEMS Microbes, 2025;, xtaf001. Abstract submitted by kickingbird at Feb, 21, 2025 from FEMS Microbes, 2025;, xtaf001 (via https://academic.oup.com/femsmicrobes/advance-article/doi/10) Avian influenza virus (AIV) poses significant threats to poultry and human health. This study investigates the impact of H9N2 AIV infection on the respiratory microbiota of chickens using 16S rRNA gene ... Albert Perlas, Tim Reska, Guillaume Croville, Ferr. Improvements in RNA and DNA nanopore sequencing allow for rapid genetic characterization of avian influenza. Virus Evolution, 2025;, veaf010. Abstract submitted by kickingbird at Feb, 21, 2025 from Virus Evolution, 2025;, veaf010 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v) Avian influenza virus (AIV) currently causes a panzootic with extensive mortality in wild birds, poultry, and wild mammals, thus posing a major threat to global health and underscoring the need for efficient ... Naraharisetti R, Weinberg M, Stoddard B, et al. Highly Pathogenic Avian Influenza A(H5N1) Virus Infection of Indoor Domestic Cats Within Dairy Industry Worker Households - Michigan, May 2024. MMWR Morb Mortal Wkly Rep 2025;74:61-65. Abstract submitted by kickingbird at Feb, 21, 2025 from MMWR Morb Mortal Wkly Rep 2025;74:61-65 (via https://www.cdc.gov/mmwr/volumes/74/wr/mm7405a2.htm) Highly pathogenic avian influenza (HPAI) A(H5N1) virus, clade 2.3.4.4b, genotype B3.13 infection has been documented in cats on U.S. dairy cattle farms. In May 2024, the detection of HPAI A(H5N1) virus ... Li X, Li L, Tian J, Su R, Sun J, Li Y, Wang L, Zho. SREBP2-dependent lipid droplet formation enhances viral replication and deteriorates lung injury in mice following IAV infection. Emerg Microbes Infect. 2025 Feb 19:2470371. Abstract submitted by kickingbird at Feb, 20, 2025 from Emerg Microbes Infect. 2025 Feb 19:2470371 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2) Influenza A virus (IAV) is a significant zoonotic pathogen that poses a considerable challenge to public health due to its continuous mutations. Lipid droplets (LDs) have been shown to play an important ... Signore AV, Joseph T, Ranadheera C, Erdelyan CNG,. Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024. Emerg Microbes Infect. 2025 Feb 18:2469643. Abstract submitted by kickingbird at Feb, 20, 2025 from Emerg Microbes Infect. 2025 Feb 18:2469643 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2) We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused ... Wu J, Zhang X, Zhao Y, Zhang S, Wang Y, Yang W, Li. North American-Origin Influenza A (H10) viruses in Eurasian Wild Birds (2022-2024): Implications for the Emergence of Human H10N5 Virus. Emerg Microbes Infect. 2025 Feb 17:2465308. Abstract submitted by kickingbird at Feb, 18, 2025 from Emerg Microbes Infect. 2025 Feb 17:2465308 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2) During our surveillance of avian influenza viruses (AIVs) in wild birds across China, H10Nx viruses were isolated from diverse migratory flyways between 2022 and 2024. We identified one wild-bird H10N5 ... Cheng Z, Sun Y, Shen Y, Wu X, Pan L, Wu H, Bai Y,. A Single Mutation at Position 214 of Influenza B Hemagglutinin Enhances Cross-Neutralization. Emerg Microbes Infect. 2025 Feb 17:2467770. Abstract submitted by kickingbird at Feb, 18, 2025 from Emerg Microbes Infect. 2025 Feb 17:2467770 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2) High variability of influenza B virus (IBV) hemagglutinin (HA) impairs the cross- neutralization ability of vaccines, leading to reduce efficacy. We identified significant differences in cross-neutralization ... Oona Liedes, etc.,al. [preprint]Inactivated Zoonotic Influenza A(H5N8) Vaccine Induces Robust Antibody Responses Against Recent Highly Pathogenic Avian Influenza Clade 2.3.4.4b A(H5N1) Viruses. https://doi.org/10.1101/2025.02.12.25322044. Abstract submitted by kickingbird at Feb, 17, 2025 from https://doi.org/10.1101/2025.02.12.25322044 (via https://www.medrxiv.org/content/10.1101/2025.02.12.25322044v) In 2023, Finland faced an outbreak of highly pathogenic avian influenza caused by clade 2.3.4.4b A(H5N1) viruses, which spread from wild birds to fur farms. Vaccinations of individuals at-risk, such as ... Han J, Kim S, Kang D, Lee SH, Cho AY, Lee H, Kwon. Near-Infrared Long-Lived Luminescent Nanoparticle-Based Time-Gated Imaging for Background-Free Detection of Avian Influenza Virus. ACS Sens. 2025 Feb 15. Abstract submitted by kickingbird at Feb, 17, 2025 from ACS Sens. 2025 Feb 15 (via https://pubs.acs.org/doi/10.1021/acssensors.4c03202) Near-infrared (NIR)-to-NIR upconversion nanoparticles (UCNPs) are promising materials for biomedical imaging and sensing applications. However, UCNPs with long lifetimes continue to face the limitation ... Kobayashi D, Hiono T, Arakawa H, Kaji H, Ohkawara. Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens. J Virol. 2025 Feb 14:e0147824. Abstract submitted by kickingbird at Feb, 15, 2025 from J Virol. 2025 Feb 14:e0147824 (via https://journals.asm.org/doi/10.1128/jvi.01478-24) Influenza A viruses with fewer amino acids in the neuraminidase (NA) stalk domain are primarily isolated from chickens rather than wild ducks, indicating that a shortened NA stalk is considered an adaptation ... Kaitlyn M. Sarlo Davila, etc.,al. [preprint]Transmission of highly pathogenic avian influenza H5N1 to calves fed unpasteurized milk from experimentally infected cows. https://doi.org/10.31220/agriRxiv.2025.0030. Abstract submitted by kickingbird at Feb, 14, 2025 from https://doi.org/10.31220/agriRxiv.2025.0030 (via https://www.cabidigitallibrary.org/doi/10.31220/agriRxiv.202) Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b genotype B3.13 was confirmed in a dairy cow in Texas on March 25, 2024, by the US Department of Agriculture (USDA) National Veterinary Services ... Peter Cronin, Jurre Siegers, Vireak Heang et al. [preprint]Air sampling accurately captures circulating zoonotic viral diversity emerging from poultry live-animal markets. https://doi.org/10.21203/rs.3.rs-5682962/v1. Abstract submitted by kickingbird at Feb, 14, 2025 from https://doi.org/10.21203/rs.3.rs-5682962/v1 (via https://www.researchsquare.com/article/rs-5682962/v1) Environmental surveillance has emerged as a pivotal strategy for early detection of pathogens that pose threats to humans (1) but has not been utilized for zoonotic agents. In Asia, live-bird markets (LBMs) ... Liang Wang, George F. Gao. A brief history of human infections with H5Ny avian influenza viruses. Cell Host & Microbe, Volume 33, Issue 2, 176 - 181. Abstract submitted by kickingbird at Feb, 14, 2025 from Cell Host & Microbe, Volume 33, Issue 2, 176 - 181 (via https://www.cell.com/cell-host-microbe/abstract/S1931-3128(2) The H5 subtype of avian influenza viruses (AIVs) presents a continued threat to human health, intensifying with the H5N1 outbreak in cattle herds and onward transmission to humans. In this commentary, ... Alexander Nagy, Lenka ?erníková, Kamil Sedlák. [preprint]Genetic data and meteorological conditions: unravelling the windborne transmission of H5N1 high-pathogenicity avian influenza between commercial poultry outbreaks. https://doi.org/10.1101/2025.02.12.637829. Abstract submitted by kickingbird at Feb, 13, 2025 from https://doi.org/10.1101/2025.02.12.637829 (via https://www.biorxiv.org/content/10.1101/2025.02.12.637829v1) Understanding the transmission routes of high-pathogenicity avian influenza (HPAI) is crucial for developing effective control measures to prevent its spread. 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