Wang X, Lin L, Chen Z, Si W, Yan Y, Dong W, Jin Y,. Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG-I-like receptors mediated antiviral responses. Antiviral Res. 2023 May 23:105641. Abstract
submitted by kickingbird at May, 26, 2023 from Antiviral Res. 2023 May 23:105641 (via https://www.sciencedirect.com/science/article/pii/S016635422)
RIG-I-like receptors (RLRs), retinoic acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), are pattern recognition receptors through which cells initially sense pathogenic ... Liang Y, Sun Z, Hua W, Li D, Han L, Liu J, Huo L,. Spatiotemporal effects of meteorological conditions on global influenza peaks. Environ Res. 2023 May 23:116171. Abstract
submitted by kickingbird at May, 26, 2023 from Environ Res. 2023 May 23:116171 (via https://www.sciencedirect.com/science/article/abs/pii/S00139)
Background: Numerous studies have suggested that meteorological conditions such as temperature and absolute humidity are highly indicative of influenza outbreaks. However, the explanatory power of meteorological ... Yang J, Zhang C, Yuan Y, Sun J, Lu L, Sun H, Sun H. Novel Avian Influenza Virus (H5N1) Clade 2.3.4.4b Reassortants in Migratory Birds, China. Emerg Infect Dis. 2023 Jun;29(6):1244-1249. Abstract
submitted by kickingbird at May, 22, 2023 from Emerg Infect Dis. 2023 Jun;29(6):1244-1249 (via https://wwwnc.cdc.gov/eid/article/29/6/22-1723_article)
Two novel reassortant highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2 were identified in dead migratory birds in China in November 2021. The viruses probably evolved among wild birds ... Lee SH, Cho AY, Kim TH, Ahn SJ, Song JH, Lee H, Ch. Novel Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus in Wild Birds, South Korea. Emerg Infect Dis. 2023 May 19;29(7). Abstract
submitted by kickingbird at May, 22, 2023 from Emerg Infect Dis. 2023 May 19;29(7) (via https://pubmed.ncbi.nlm.nih.gov/37204922/)
We isolated 5 highly pathogenic avian influenza A(H5N1) clade 2.3.4.4.b viruses from wild waterfowl feces in South Korea during November 2022. Whole-genome sequencing and phylogenetic analysis revealed ... Sreenivasan CC, Liu R, Gao R, Guo Y, Hause BM, Tho. Influenza C and D Viruses Demonstrated a Differential Respiratory Tissue Tropism in a Comparative Pathogenesis Study in Guinea Pigs. J Virol. 2023 May 18:e0035623. Abstract
submitted by kickingbird at May, 19, 2023 from J Virol. 2023 May 18:e0035623 (via https://journals.asm.org/doi/10.1128/jvi.00356-23)
Influenza C virus (ICV) is increasingly associated with community-acquired pneumonia (CAP) in children and its disease severity is worse than the influenza B virus, but similar to influenza A virus associated ... Ferrando VA, Friedrich ME, Gandhi S, Mellmann A, M. Cell-intrinsic genomic reassortment of pandemic H1N1 2009 and Eurasian avian-like swine influenza viruses results in potentially zoonotic variants. Emerg Microbes Infect. 2023 May 16:2212809. Abstract
submitted by kickingbird at May, 17, 2023 from Emerg Microbes Infect. 2023 May 16:2212809 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Influenza A viruses (IAV) cause annual epidemics and occasional pandemics in humans. The most recent pandemic outbreak occurred in 2009 with H1N1pdm09. This virus, which most likely reassorted in swine ... Mazel-Sanchez B, Niu C, Williams N, Bachmann M, Ch. Influenza A virus exploits transferrin receptor recycling to enter host cells. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e221. Abstract
submitted by kickingbird at May, 17, 2023 from Proc Natl Acad Sci U S A. 2023 May 23;120(21):e221 (via https://www.pnas.org/doi/10.1073/pnas.2214936120)
Influenza A virus (IAV) enters host cells mostly through clathrin-dependent receptor-mediated endocytosis. A single bona fide entry receptor protein supporting this entry mechanism remains elusive. Here ... Zhang L, Wang Y, Shao Y, Guo J, Gao GF, Deng T. Fine Regulation of Influenza Virus RNA Transcription and Replication by Stoichiometric Changes in Viral NS1 and NS2 Proteins. J Virol. 2023 May 11:e0033723. Abstract
submitted by kickingbird at May, 12, 2023 from J Virol. 2023 May 11:e0033723 (via https://journals.asm.org/doi/10.1128/jvi.00337-23)
In the influenza virus life cycle, viral RNA (vRNA) transcription (vRNA→mRNA) and replication (vRNA→cRNA→vRNA), catalyzed by the viral RNA-dependent RNA polymerase in the host cell nucleus, are delicately ... James J, Billington E, Warren CJ, De Sliva D, Di G. Clade 2.3.4.4b H5N1 high pathogenicity avian influenza virus (HPAIV) from the 2021/22 epizootic is highly duck adapted and poorly adapted to chickens. J Gen Virol. 2023 May;104(5).. Abstract
submitted by kickingbird at May, 12, 2023 from J Gen Virol. 2023 May;104(5). (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
The 2021/2022 epizootic of high pathogenicity avian influenza (HPAIV) remains one of the largest ever in the UK, being caused by a clade 2.3.4.4b H5N1 HPAIV. This epizootic affected more than 145 poultry ... Lin X, Zhu M, Zhao X, Si L, Dong M, Anirudhan V, C. Optimization and applications of an in vivo bioluminescence imaging model of influenza a virus infections. Virol Sin. 2023 May 2:S1995-820X(23)00045-7. Abstract
submitted by kickingbird at May, 8, 2023 from Virol Sin. 2023 May 2:S1995-820X(23)00045-7 (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Highlights?The in vivo BLI model of IAV infections can simplify the determination of viral load in living animals.?The in vivo BLI model of IAV infections allow longitudinal measurements of virus infection/spread ... Mirska B, Wo?niak T, Lorent D, Ruszkowska A, Peter. In vivo secondary structural analysis of Influenza A virus genomic RNA. Cell Mol Life Sci. 2023 May 2;80(5):136. Abstract
submitted by kickingbird at May, 4, 2023 from Cell Mol Life Sci. 2023 May 2;80(5):136 (via https://link.springer.com/article/10.1007/s00018-023-04764-1)
Influenza A virus (IAV) is a respiratory virus that causes epidemics and pandemics. Knowledge of IAV RNA secondary structure in vivo is crucial for a better understanding of virus biology. Moreover, it ... Alvarez I, H?gglund S, N?slund K, Eriksson A, Ahlg. Detection of Influenza D-Specific Antibodies in Bulk Tank Milk from Swedish Dairy Farms. Viruses. 2023 Mar 24;15(4):829. Abstract
submitted by kickingbird at May, 1, 2023 from Viruses. 2023 Mar 24;15(4):829 (via https://www.mdpi.com/1999-4915/15/4/829)
Influenza D virus (IDV) has been detected in bovine respiratory disease (BRD) outbreaks, and experimental studies demonstrated this virus's capacity to cause lesions in the respiratory tract. In addition, ... Abdelwhab EM, Mettenleiter TC. Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts. Viruses. 2023 Apr 16;15(4):980. Abstract
submitted by kickingbird at May, 1, 2023 from Viruses. 2023 Apr 16;15(4):980 (via https://www.mdpi.com/1999-4915/15/4/980)
Influenza viruses belong to the family Orthomyxoviridae with a negative-sense, single-stranded segmented RNA genome. They infect a wide range of animals, including humans. From 1918 to 2009, there were ... Ghafoori SM, Petersen GF, Conrady DG, Calhoun BM,. Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site. Sci Rep. 2023 Apr 28;13(1):6940. Abstract
submitted by kickingbird at May, 1, 2023 from Sci Rep. 2023 Apr 28;13(1):6940 (via https://www.nature.com/articles/s41598-023-33529-w)
Influenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to the healthcare system in the billions of dollars. Several influenza pandemics have occurred during ... Liu L, Madhugiri R, Saul VV, Bacher S, Kracht M, P. Phosphorylation of the PA subunit of influenza polymerase at Y393 prevents binding of the 5´-termini of RNA and polymerase function. Sci Rep. 2023 Apr 29;13(1):7042. Abstract
submitted by kickingbird at May, 1, 2023 from Sci Rep. 2023 Apr 29;13(1):7042 (via https://www.nature.com/articles/s41598-023-34285-7)
The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. ... Guo Y, Sun T, Bai X, Liang B, Deng L, Zheng Y, Yu. Comprehensive analysis of the key amino acid substitutions in the polymerase and NP of avian influenza virus that enhance polymerase activity and affect adaptation to mammalian hosts. Vet Microbiol. 2023 Apr 25;282:109760. Abstract
submitted by kickingbird at May, 1, 2023 from Vet Microbiol. 2023 Apr 25;282:109760 (via https://www.sciencedirect.com/science/article/abs/pii/S03781)
Accumulation of adaptive mutations in the polymerase and NP genes is crucial for the adaptation of avian influenza A viruses (IAV) to a new host. Here, we identified residues in the polymerase and NP proteins ... Hui KPY, Ho JCW, Ng KC, Cheng SMS, Sit KY, Au TWK,. Replication of Novel Zoonotic-Like Influenza A(H3N8) Virus in Ex Vivo Human Bronchus and Lung. Emerg Infect Dis. 2023 Apr 24;29(6). Abstract
submitted by kickingbird at Apr, 27, 2023 from Emerg Infect Dis. 2023 Apr 24;29(6) (via https://pubmed.ncbi.nlm.nih.gov/37095078/)
Human infection with avian influenza A(H3N8) virus is uncommon but can lead to acute respiratory distress syndrome. In explant cultures of the human bronchus and lung, novel H3N8 virus showed limited replication ... Bhat P, Aksenova V, Gazzara M, Rex EA, Aslam S, Ha. Influenza virus mRNAs encode determinants for nuclear export via the cellular TREX-2 complex. Nat Commun. 2023 Apr 21;14(1):2304. Abstract
submitted by kickingbird at Apr, 24, 2023 from Nat Commun. 2023 Apr 21;14(1):2304 (via https://www.nature.com/articles/s41467-023-37911-0)
Nuclear export of influenza A virus (IAV) mRNAs occurs through the nuclear pore complex (NPC). Using the Auxin-Induced Degron (AID) system to rapidly degrade proteins, we show that among the nucleoporins ... Guo Z, He Y, Xu J, Benegal AN, Brody SL, Vahey MD. Neuraminidase Activity Modulates Cellular Coinfection during Influenza A Virus Multicycle Growth. mBio. 2023 Apr 20:e0359122. Abstract
submitted by kickingbird at Apr, 24, 2023 from mBio. 2023 Apr 20:e0359122 (via https://journals.asm.org/doi/10.1128/mbio.03591-22)
Infection of individual cells by multiple virions plays critical roles in the replication and spread of many viruses, but mechanisms that control cellular coinfection during multicycle viral growth remain ... Sun JY, Guo CY, Wang GR, Yan LT, Feng Q, Li Y, Huo. Identification of Heterophilic Epitopes of H1N1 Influenza Virus Hemagglutinin. Curr Microbiol. 2023 Apr 19;80(5):188. Abstract
submitted by kickingbird at Apr, 20, 2023 from Curr Microbiol. 2023 Apr 19;80(5):188 (via https://link.springer.com/article/10.1007/s00284-023-03294-0)
Our previous studies found that the H1-50 monoclonal antibody (mAb) of influenza A virus hemagglutinin (HA) cross-reacted with pancreatic tissue and islet β-cells, and further studies showed that H1-50 ... 5162 items, 20/Page, Page[20/259][|<<] [|<] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [>|] [>>|] |
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