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2026-10-7 13:42:29
Article

Carrazco-Montalvo A, Luje L, Rodríguez-Pólit C, Am. Genomic characterization of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b into wild seabirds from coastal Ecuador. Front. Microbiol. 17:1953002.  Abstract  
submitted by kickingbird at 12 days ago from Front. Microbiol. 17:1953002 (via https://www.frontiersin.org/journals/microbiology/articles/1)
Introduction: Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b has spread widely across South America, but its genomic diversity and patterns of introduction into Ecuador remain poorly characterized.Methods: ...

Mattia Sensi, etc.,al. [preprint]Modelling assessment of the different paths of between-farm transmission of avian influenza HPAI in Northern Italy in 2021-2022. https://doi.org/10.64898/2026.09.19.752832.  Abstract  
submitted by kickingbird at 12 days ago from https://doi.org/10.64898/2026.09.19.752832 (via https://www.biorxiv.org/content/10.64898/2026.09.19.752832v1)
We propose a stochastic epidemic model to describe the spread of avian influenza in a network of poultry farms. We consider three main paths of infection transmission between poultry farms: from nearby ...

Madeleine Blondin-Brosseau, etc.,al. Investigation of the Effect of Simulated Gastrointestinal Digestive Fluids on the Infectivity of Influenza A Virus H1N1. Food Microbiology.  Abstract  
submitted by kickingbird at 12 days ago from Food Microbiology (via https://www.sciencedirect.com/science/article/abs/pii/S07400)
The recent emergence of highly pathogenic avian influenza (HPAI) in dairy cattle has raised concerns about potential non-respiratory exposure routes including ingestion of contaminated raw milk. In this ...

Hussain S, Chia C, Muraleetharan A, Deng YM, Dong. A Cluster of Influenza A(H3N2) Viruses in 2024 From Tasmania, Australia, With Reduced Susceptibility to Baloxavir. Influenza Other Respir Viruses. 2026 Sep;20(9):e70.  Abstract  
submitted by kickingbird at 12 days ago from Influenza Other Respir Viruses. 2026 Sep;20(9):e70 (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70312)
The emergence of viruses with reduced susceptibility to antivirals poses an ongoing risk which could limit their effectiveness. Here we report a cluster of A(H3N2) viruses detected in Tasmania, Australia, ...

Koumaty L, Dan S, De Clercq A, Destras G, Regue H,. Emergence of a genetically distinct cluster of influenza A(H3N2) viruses within subclade J.2.2 associated with hospitalization during the 2024-2025 season in Auvergne-Rh?ne-Alpes, France. Microb Genom. 2026 Sep;12(9):001810.  Abstract  
submitted by kickingbird at 13 days ago from Microb Genom. 2026 Sep;12(9):001810 (via https://www.microbiologyresearch.org/content/journal/mgen/10)
During the 2024-2025 influenza season in Auvergne-Rh?ne-Alpes, France, a genetically distinct cluster of A(H3N2) viruses within subclade J.2.2 was found to be significantly overrepresented in hospitalized ...

Ullah R, Chen W, Zhang L, Guo C, Ren B, Pei X, Yan. Interaction between DEAD-box RNA helicase 10 and influenza PB1 polymerase selectively regulates influenza A virus replication. J Virol. 2026 Sep 22:e0081526.  Abstract  
submitted by kickingbird at 13 days ago from J Virol. 2026 Sep 22:e0081526 (via https://journals.asm.org/doi/10.1128/jvi.00815-26)
Identifying the host factors that mediate avian influenza virus adaptation in mammals is important for monitoring zoonotic potential. Although viral polymerase adaptations are known to influence cross-species ...

Jang Y, Cha RM, Park MJ, Kim JM, Lim EH, Heo GB, A. Genetic Diversity of Clade 2.3.4.4b H5Nx High Pathogenicity Avian Influenza Viruses Detected in Korea During the 2025-2026 Winter Season and Pathogenicity of H5N1 and H5N9 Viruses. Virus Res. 2026 Sep 22:199807.  Abstract  
submitted by kickingbird at 13 days ago from Virus Res. 2026 Sep 22:199807 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Clade 2.3.4.4b H5N1, H5N6, and H5N9 high pathogenicity avian influenza viruses (HPAIVs) were detected in poultry and wild birds during the 2025-2026 winter season in Korea. During this period, 62 H5Nx ...

Lemus-Reyes JI, Fernández-Quintero ML, Ayala E, Sw. Antigenic and structural analysis of the influenza hemagglutinin lateral patch. J Virol. 2026 Sep 23:e0126526.  Abstract  
submitted by kickingbird at 13 days ago from J Virol. 2026 Sep 23:e0126526 (via https://journals.asm.org/doi/10.1128/jvi.01265-26)
The lateral patch epitope of the H1 hemagglutinin (HA) was a dominant target of antibodies following exposure to the 2009 pandemic H1N1 virus. However, the conservation and mechanisms of antigenic drift ...

Marougka K, Leiva-Rebollo R, Hofma F, van Dijk A,. Substitutions affecting the HA-NA-receptor balance preceded the emergence of the pandemic 2009 H1N1 virus. Proc Natl Acad Sci U S A. 2026 Sep 29;123(39):e260.  Abstract  
submitted by kickingbird at 13 days ago from Proc Natl Acad Sci U S A. 2026 Sep 29;123(39):e260 (via https://www.pnas.org/doi/10.1073/pnas.2609870123)
Swine are a crucial species in influenza A virus (IAV) ecology, capable of supporting replication and consequently evolution of human, avian, and swine strains. They are also the source of the 2009 pandemic ...

Min SC, Lee JR, Kim BK, Park J-H, Lee DG, Lee GC,. Comparison of Baloxavir-Based Combinations and Monotherapies for Treating Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Mice. Emerg Infect Dis. 2026 Oct.  Abstract  
submitted by kickingbird at 13 days ago from Emerg Infect Dis. 2026 Oct (via https://wwwnc.cdc.gov/eid/article/32/10/26-0186_article)
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b virus continues to cause animal outbreaks and sporadic zoonotic infections. In a mouse model of lethal influenza disease, we compared oseltamivir, ...

Pranav S Kulkarni, etc.,al. [preprint]Estimation of the transmission dynamics of H5N1 HPAI outbreak in a dairy herd using a modeling approach. https://doi.org/10.64898/2026.09.22.753543.  Abstract  
submitted by kickingbird at 13 days ago from https://doi.org/10.64898/2026.09.22.753543 (via https://www.biorxiv.org/content/10.64898/2026.09.22.753543v1)
The emergence of Highly Pathogenic Avian Influenza (HPAI 2.3.4.4b) in dairy herds in 2024 across 19 states in the United States of America has raised concerns regarding the potential national and global ...

Li X, Xiao K, Zhou C, Jia X, Zhao D, Xu J, Zeng X,. VirPLM: Antigenic prediction of influenza A/H3N2 viruses with a fine-tuned protein language model. Bioinformatics. 2026 Sep 18:btag692.  Abstract  
submitted by kickingbird at 14 days ago from Bioinformatics. 2026 Sep 18:btag692 (via https://academic.oup.com/bioinformatics/advance-article/doi/)
Motivation: Human influenza A/H3N2 viruses undergo rapid antigenic evolution primarily driven by the hemagglutinin subunit 1 (HA1). Within HA1, amino acid substitutions under immune pressure cause antigenic ...

Johanna Hol H Fosse, etc.,al. [preprint]Serological Evidence of Widespread Exposure to H5 Avian Influenza Virus in Arctic Foxes in Svalbard, Norway. https://doi.org/10.64898/2026.09.17.752278.  Abstract  
submitted by kickingbird at 15 days ago from https://doi.org/10.64898/2026.09.17.752278 (via https://www.biorxiv.org/content/10.64898/2026.09.17.752278v1)
The continued circulation of H5 clade 2.3.4.4b highly pathogenic avian influenza virus (HPAIV) has caused extensive mortality in wild bird populations worldwide with increasing spillover to mammals. In ...

Hatta, M., Huang, Y., Duke, J. A., Rouse, J. R., F. Limited added benefit of seasonal influenza vaccination before A(H5) vaccination in mice and ferrets challenged with A(H5N1). Emerging Microbes & Infections, 15(1).  Abstract  
submitted by kickingbird at 15 days ago from Emerging Microbes & Infections, 15(1) (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
Limited A(H5)-specific vaccine supply is expected early in a potential A(H5N1) pandemic, raising the question of whether licensed seasonal influenza vaccines could enhance protection when administered ...

Bui NA, Song ZY, Cheng SMS, Dao DT, Chang LDJ, Liu. Molecular Epidemiology and Evolution of Swine Influenza A Viruses, Vietnam, 2020-2024. Emerg Infect Dis. 2026 Oct.  Abstract  
submitted by kickingbird at 15 days ago from Emerg Infect Dis. 2026 Oct (via https://wwwnc.cdc.gov/eid/article/32/10/26-0593_article)
Swine influenza A viruses (IAV-S) caused the 2009 H1N1 pandemic and pose a future zoonotic and pandemic threat. Vietnam represents a critical hotspot for IAV-S emergence within East and Southeast Asia, ...

Ga, E., Xie, X., Hwang, J. et al. Host-specific effects of a pandemic H1N1 M gene on canine H3N2 influenza virus replication and immune responses. Sci Rep (2026).  Abstract  
submitted by kickingbird at Sep, 19, 2026 from Sci Rep (2026) (via https://link.springer.com/article/10.1038/s41598-026-70452-2)
The emergence of novel influenza strains through reverse-zoonotic transmission poses potential risks to both animal and human health. This study characterized a naturally isolated reassortant canine H3N2 ...

Wan Z, Jiang W, Cao X, Guo X, He X, Zhang J, Chu X. Novel emerging reassortant H6 avian influenza viruses with internal genes from G57 genotype of H9N2 pose potential zoonotic risk. Emerg Microbes Infect. 2026 Dec;15(1):2732846.  Abstract  
submitted by kickingbird at Sep, 19, 2026 from Emerg Microbes Infect. 2026 Dec;15(1):2732846 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
In recent decades, multiple novel reassortant avian influenza viruses (AIVs) carrying internal genes derived from H9N2 viruses have emerged in poultry in China and have repeatedly caused human infections, ...

Fan, M., Liu, Z., Deng, L. et al. LncFENIX restricts influenza A virus replication by impairing PDIA3-mediated oxidative folding of hemagglutinin. Cell Commun Signal (2026).  Abstract  
submitted by kickingbird at Sep, 18, 2026 from Cell Commun Signal (2026) (via https://link.springer.com/article/10.1186/s12964-026-03228-w)
BackgroundInfluenza A virus (IAV) relies on host endoplasmic reticulum (ER) homeostasis machinery to support the oxidative folding and maturation of viral glycoproteins. Although long non-coding RNAs (lncRNAs) ...

Seibert, B.A., Parish, M.A., Talukdar, S.N. et al. Trimester-dependent vertical transmission of H5N1 influenza virus through placental and mammary routes impairs offspring development. Nat Commun 17, 9968 (2026).  Abstract  
submitted by kickingbird at Sep, 18, 2026 from Nat Commun 17, 9968 (2026) (via https://www.nature.com/articles/s41467-026-76891-9)
Avian influenza H5N1 has pandemic potential and historically causes more severe disease in pregnant women than the general population. With increasing transmission of H5N1 detected among placental mammals, ...

Caroline Kikawa, etc.,al. [preprint]Near real-time data on the human neutralizing antibody landscape to influenza virus in summer of 2026 shows antigenic advance of H3N2 subclade K region D mutants and H1N1 D.3.1.1 Sa mutants. https://doi.org/10.64898/2026.09.15.751855.  Abstract  
submitted by kickingbird at Sep, 18, 2026 from https://doi.org/10.64898/2026.09.15.751855 (via https://www.biorxiv.org/content/10.64898/2026.09.15.751855v1)
Human seasonal influenza evolves rapidly, necessitating twice yearly decisions about whether to update the strains in the vaccine. To help inform this decision, we have been using high-throughput sequencing-based ...

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