Li, ZN., Liu, F., Jung, YJ. et al. Pre-existing cross-reactive immunity to highly pathogenic avian influenza 2.3.4.4b A(H5N1) virus in the United States. Nat Commun 16, 10954 (2025). Abstract
submitted by kickingbird at 9 days ago from Nat Commun 16, 10954 (2025) (via https://link.springer.com/article/10.1038/s41467-025-66431-2)
The unprecedented 2.3.4.4b. A(H5N1) outbreak in dairy cattle, poultry, and spillover to humans in the United States (US) poses a major public health threat. Population immunity is a critical component ... Son, SE., An, SH., Lee, CY. et al. Evolutionary trajectories and zoonotic potential of a PB2 mutation triad (I147T, K339T, and A588T) in avian influenza viruses. Vet Res (2025). Abstract
submitted by kickingbird at 9 days ago from Vet Res (2025) (via https://link.springer.com/article/10.1186/s13567-025-01680-z)
Efficient replication of influenza A viruses (IAVs) requires balanced activities of hemagglutinin (HA), neuraminidase (NA), and the RNA polymerase complex, whose functions are strongly influenced by PB2 ... Agustina Rimondi, etc.,al. [preprint]Persistence and spillback of mammal-adapted H5N1 genotype B3.2 viruses among South American seabirds and marine mammals. https://doi.org/10.21203/rs.3.rs-7960151/v1. Abstract
submitted by kickingbird at 9 days ago from https://doi.org/10.21203/rs.3.rs-7960151/v1 (via https://www.researchsquare.com/article/rs-7960151/v1)
The arrival of H5N1 clade 2.3.4.4b genotype B3.2 in South America marks an unprecedented geographic expansion of highly pathogenic avian influenza viruses. The continent remains the only region with sustained ... Hu J, Li J, You W, Liu L, Chen H. Disruption of the local vRNA structure at the end of HA encoding region interferes with the selective packaging of influenza A virus genome. Biochem Biophys Res Commun. 2025 Dec 3;795:153082. Abstract
submitted by kickingbird at 9 days ago from Biochem Biophys Res Commun. 2025 Dec 3;795:153082 (via https://www.sciencedirect.com/science/article/abs/pii/S00062)
Influenza A virus (IAV) selectively packages eight distinct viral RNA (vRNA) segments into progeny virions through segment-specific packaging signals located in the noncoding regions and their adjacent ... Jin Y, Cui H, Jiang L, et al. From Surfaces to Spillover: Environmental Persistence and Indirect Transmission of Influenza A(H3N8) Virus. Microorganisms. 2025; 13(12):2782. Abstract
submitted by kickingbird at 10 days ago from Microorganisms. 2025; 13(12):2782 (via https://www.mdpi.com/2076-2607/13/12/2782)
Avian influenza viruses (AIVs) pose a significant zoonotic threat, with the emerging H3N8 subtype raising increasing concern due to sporadic human infections. Current strategies for risk assessment of ... Liedes, O., Reinholm, A., Ekstr?m, N. et al. Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individuals. Nat Microbiol (2025). Abstract
submitted by kickingbird at 11 days ago from Nat Microbiol (2025) (via https://www.nature.com/articles/s41564-025-02183-5)
Finland faced an outbreak of highly pathogenic clade 2.3.4.4b A(H5N1) avian influenza in 2023, which spread from wild birds to fur farms. Vaccinations of at-risk individuals began in June 2024 using the ... Kephart, S.M., Awatramani, K.F., Saunders, M.I. et. Host switching mutations in H5N1 influenza hemagglutinin suppress site-specific activation dynamics. Nat Commun (2025). Abstract
submitted by kickingbird at 11 days ago from Nat Commun (2025) (via https://link.springer.com/article/10.1038/s41467-025-66926-y)
Increase in human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI gaining human transmissibility. ... Saubi N, Andrés C, Prats-Méndez I, González-Sánche. Expansion of influenza A(H1N1)pdm09 NA:S247N viruses with reduced susceptibility to oseltamivir, Catalonia, Spain, and in Europe, July to October 2025. Euro Surveill. 2025 Dec;30(48). Abstract
submitted by kickingbird at 11 days ago from Euro Surveill. 2025 Dec;30(48) (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
Between July and October 2025, among the total 117 influenza A(H1N1)pdm09 strains characterised in Catalonia, 20% to 100% per week were carrying the NA:S247N substitution. The mutation, conferring reduced ... Matyszewska D, Kapu?cińska M, Fontaine P. Elucidating the nature of the interactions of oseltamivir with the 2D model of influenza A virus lipid envelope. Colloids Surf B Biointerfaces. 2025 Nov 29;259:115. Abstract
submitted by kickingbird at 11 days ago from Colloids Surf B Biointerfaces. 2025 Nov 29;259:115 (via https://www.sciencedirect.com/science/article/pii/S092777652)
This study investigates the molecular interactions of the antiviral agent oseltamivir phosphate (OSL) with a two-dimensional (2D) Langmuir monolayer model of the influenza A (AH1N1) virus lipid envelope. ... Qian Zhang, etc.,al. Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza. J Exp Med 2 March 2026; 223 (3): e20251962. Abstract
submitted by kickingbird at 11 days ago from J Exp Med 2 March 2026; 223 (3): e20251962 (via https://rupress.org/jem/article/223/3/e20251962/278557/Autoa)
Avian influenza A virus (IAV) H5N1 is an emerging threat of human pandemic. We describe a 71-year-old man who died of H5N1 pneumonia in Louisiana and whose blood contained autoantibodies neutralizing type ... An Y, Ding X, Tian Y, Zhang M, Ma Y, Wu X, Cai M,. High-throughput pseudovirus neutralisation maps the antigenic landscape of influenza A/H1N1 viruses. EBioMedicine. 2025 Dec 2;122:106047. Abstract
submitted by kickingbird at 12 days ago from EBioMedicine. 2025 Dec 2;122:106047 (via https://www.thelancet.com/journals/ebiom/article/PIIS2352-39)
Background: The continuous mutations in the haemagglutinin gene in A/H1N1 influenza viruses drives antigenic drift, necessitating frequent vaccine updates. Pseudovirus systems, with their flexible HA protein ... Huddleston J, Bedford T. Timely vaccine strain selection and genomic surveillance improve evolutionary forecast accuracy of seasonal influenza A/H3N2. Elife. 2025 Dec 4;14:RP104282. Abstract
submitted by kickingbird at 12 days ago from Elife. 2025 Dec 4;14:RP104282 (via https://elifesciences.org/articles/104282)
Evolutionary forecasting models inform seasonal influenza vaccine design by predicting which current genetic variants will dominate in the influenza season 12 months later. Forecasting models depend on ... Guan L, etc., al. Stability of Avian Influenza A(H5N1) Virus in Milk from Infected Cows and Virus-Spiked Milk. N Engl J Med . 2025 Dec 4;393(22):2271-2273. Abstract
submitted by kickingbird at 13 days ago from N Engl J Med . 2025 Dec 4;393(22):2271-2273 (via https://www.nejm.org/doi/10.1056/NEJMc2502494)
In March 2024, public health agencies in the United States reported highly pathogenic avian influenza (HPAI) virus of subtype A(H5N1) in dairy cattle, with virus detected in milk samples from symptomatic ... Kerry Goldin, Meaghan Flagg, Tessa Lutterman, etc. Contemporary highly pathogenic avian influenza (H5N1) viruses retain neurotropism in human cerebral organoids. Open Forum Infectious Diseases, ofaf730. Abstract
submitted by kickingbird at 14 days ago from Open Forum Infectious Diseases, ofaf730 (via https://academic.oup.com/ofid/advance-article/doi/10.1093/of)
BackgroundClade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 viruses are widely circulating in North America with unprecedented transmission into novel host species. A high incidence of neurologic ... Jaume A. Badia-Boher, Michael Schaub, etc.,al. Evaluating the demographic impacts of the highly pathogenic avian influenza panzootic. Journal of Applied Ecology. Abstract
submitted by kickingbird at 14 days ago from Journal of Applied Ecology (via https://besjournals.onlinelibrary.wiley.com/doi/10.1111/1365)
The spread of a new highly pathogenic avian influenza virus (HPAIV-H5N1) has, since 2021, triggered one of the most severe wildlife panzootic ever reported, with suspected population crashes in hundreds ... Zhang J, Cao R, Wang Y, Sun Y, Ji X, et al. Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis. PLOS Pathogens 21(10): e1013646. Abstract
submitted by kickingbird at 14 days ago from PLOS Pathogens 21(10): e1013646 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Infection and replication of enveloped viruses require host cells to supply substantial amounts of cellular cholesterol for processes such as binding, entry, trafficking, assembly, and budding. However, ... Junyi Wu, etc.,al. Emerging adaptation of BJ/94 lineage H9N2 viruses to waterfowl: insights into enhanced replication and immune activation in the host cells. Poultry Science. Abstract
submitted by kickingbird at 14 days ago from Poultry Science (via https://www.sciencedirect.com/science/article/pii/S003257912)
H9N2 influenza viruses have adapted to terrestrial avian hosts via prolonged circulation in domestic chicken populations across South and Southeast Asia. Recent surveys have documented an increased incidence ... Yu, T.C., Kikawa, C., Dadonaite, B. et al. Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza haemagglutinin. Nat Ecol Evol (2025). Abstract
submitted by kickingbird at 14 days ago from Nat Ecol Evol (2025) (via https://www.nature.com/articles/s41559-025-02895-1)
The evolution of human influenza virus haemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stability. ... Asaad, H.M., Hassanin, O., Saif-Edin, M. et al. The impact of innate and humoral immune mechanisms on vaccine induced protection against avian influenza H9N2 in broilers. Sci Rep 15, 43016 (2025). Abstract
submitted by kickingbird at 14 days ago from Sci Rep 15, 43016 (2025) (via https://www.nature.com/articles/s41598-025-28122-2)
Avian influenza virus (AIV) (H9N2) is a highly contagious avian respiratory disease that causes significant economic losses in the poultry industry sector. Although immunological responses to AIV (H9N2) ... Hayes, S., Hilton, J., Mould-Quevedo, J. et al. Ecology and environment predict spatially stratified risk of H5 highly pathogenic avian influenza clade 2.3.4.4b in wild birds across Europe. Sci Rep (2025). Abstract
submitted by kickingbird at 14 days ago from Sci Rep (2025) (via https://www.nature.com/articles/s41598-025-30651-9)
Highly pathogenic avian influenza (HPAI) represents a threat to animal and human health, with the ongoing H5N1 outbreak within the H5 2.3.4.4b clade being one of the largest on record. However, it remains ... 6499 items, 20/Page, Page[2/325][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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