Du R, Cui Q, Rong L. Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry. Viruses. 2019 May 20;11(5).. Abstract
submitted by kickingbird at May, 31, 2019 from Viruses. 2019 May 20;11(5). (via https://www.mdpi.com/1999-4915/11/5/458)
The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through ... Wu et al.. Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility. Cell Host & Microbe. Abstract
submitted by kickingbird at May, 29, 2019 from Cell Host & Microbe (via https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(1)
Egg-based seasonal influenza vaccines are the major preventive countermeasure against influenza virus. However, their effectiveness can be compromised when antigenic changes arise from egg-adaptive mutations ... Nelson SA, Sant AJ. Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus. Front Immunol. 2019 May 7;10:932.. Abstract
submitted by kickingbird at May, 29, 2019 from Front Immunol. 2019 May 7;10:932. (via https://www.frontiersin.org/articles/10.3389/fimmu.2019.0093)
Immunity to influenza is unique among pathogens, in that immune memory is established both via intermittent lung localized infections with highly variable influenza virus strains and by intramuscular vaccinations ... Farrukee R, Butler J, Reading PC, Hurt AC. Characterization of substitutions in the neuraminidase of A(H7N9) influenza viruses selected following serial passage in the presence of different neuraminidase inhibitors. Antiviral Res. 2019 May 24.. Abstract
submitted by kickingbird at May, 29, 2019 from Antiviral Res. 2019 May 24. (via https://www.sciencedirect.com/science/article/pii/S016635421)
Avian A(H7N9) infections in humans have been reported in China since 2013 and are of public health concern due to their severity and pandemic potential. Oseltamivir and peramivir are neuraminidase inhibitors ... Spackman E, et al. Assessment of replicate numbers for titrating avian influenza virus using dose-response models. J Vet Diagn Invest. 2019 May 25:1040638719853851.. Abstract
submitted by kickingbird at May, 29, 2019 from J Vet Diagn Invest. 2019 May 25:1040638719853851. (via https://www.ncbi.nlm.nih.gov/pubmed/31131714)
Embryonating chicken eggs (ECEs) are among the most sensitive laboratory host systems for avian influenza virus (AIV) titration, but ECEs are expensive and require space for storage and incubation. Therefore, ... Guinat C, Rouchy N, Camy F, Guérin JL, Paul MC. Exploring the Wind-Borne Spread of Highly Pathogenic Avian Influenza H5N8 During the 2016-2017 Epizootic in France. Avian Dis. 2018 Oct 11;63. Abstract
submitted by kickingbird at May, 29, 2019 from Avian Dis. 2018 Oct 11;63 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-s)
In winter 2016-2017, highly pathogenic avian influenza (HPAI) H5N8 virus spread in France, causing an unprecedented epizootic. During the epidemic, southwest France, where most outbreaks were reported, ... Pénzes Z, et al. Rapid Construction and Immunogenicity Testing of a Novel H5 Virus-Like Particle Prototype Vaccine Against Clade 2.3.4.4 H5N8 Highly Pathogenic Avian Influenza Virus. Avian Dis. 2018 Dec 18;63. Abstract
submitted by kickingbird at May, 29, 2019 from Avian Dis. 2018 Dec 18;63 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-s)
From October 2016 to July 2017, 47 countries have been affected by highly pathogenic avian influenza (HPAI) viruses of the H5N8 clade 2.3.4.4 subtype, including European and African, and it has been the ... Reid SM, et al. Two Single Incursions of H7N7 and H5N1 Low Pathogenicity Avian Influenza in U.K. Broiler Breeders During 2015 and 2016. Avian Dis. 2018 Dec 17;63. Abstract
submitted by kickingbird at May, 29, 2019 from Avian Dis. 2018 Dec 17;63 (via https://bioone.org/journals/Avian-Diseases/volume-63/issue-s)
Low pathogenicity (LP) avian influenza viruses (AIVs) have a natural reservoir in wild birds. These cause few (if any) overt clinical signs, but include H5 and H7 LPAIVs, which are notifiable in poultry. ... Jagadesh A, et al. Genetic characterization of hemagglutinin (HA) gene of influenza A viruses circulating in Southwest India during 2017 season. Virus Genes. 2019 May 25. Abstract
submitted by kickingbird at May, 29, 2019 from Virus Genes. 2019 May 25 (via https://link.springer.com/article/10.1007%2Fs11262-019-01675)
Molecular surveillance of influenza viruses is essential for early detection of novel variants. The aim of the present study was to analyze the hemagglutinin gene of influenza A(H1N1)pdm09 and A(H3N2) ... Zhang H, et al. Development of a multiplex real-time RT-PCR assay for simultaneous detection and differentiation of influenza A, B, C, and D viruses. Diagn Microbiol Infect Dis. 2019 Apr 29.. Abstract
submitted by kickingbird at May, 29, 2019 from Diagn Microbiol Infect Dis. 2019 Apr 29. (via https://www.ncbi.nlm.nih.gov/pubmed/31130238)
Influenza is a common and contagious respiratory disease caused by influenza A, B, C, and D viruses (IAV, IBV, ICV, and IDV). A multiplex real-time RT-PCR assay was developed for simultaneous detection ... Hu B, H?fer CT, Thiele C, Veit M. Cholesterol binding to the transmembrane region of a group 2 HA of Influenza virus is essential for virus replication affecting both virus assembly and HA´s fusion activity. J Virol. 2019 May 22.. Abstract
submitted by kickingbird at May, 26, 2019 from J Virol. 2019 May 22. (via https://www.ncbi.nlm.nih.gov/pubmed/31118253)
Hemagglutinin (HA) of Influenza virus is incorporated into cholesterol enriched, nanodomains of the plasma membrane. Phylogenetic group 2 HAs contain the conserved cholesterol consensus motif (CCM) YKLW ... Gilbert PB, et al. HAI and NAI titer correlates of inactivated and live attenuated influenza vaccine efficacy. BMC Infect Dis. 2019 May 22;19(1):453. Abstract
submitted by kickingbird at May, 26, 2019 from BMC Infect Dis. 2019 May 22;19(1):453 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BACKGROUND: High hemagglutination inhibition (HAI) and neuraminidase inhibition (NAI) titers are generally associated with reduced influenza risk. While repeated influenza vaccination reduces seroresponse, ... Zhang Y, et al. Genetic and biological characteristics of avian influenza virus subtype H1N8 in environments related to live poultry markets in China. BMC Infect Dis. 2019 May 22;19(1):458. Abstract
submitted by kickingbird at May, 26, 2019 from BMC Infect Dis. 2019 May 22;19(1):458 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
BACKGROUND: Since 2008, avian influenza surveillance in poultry-related environments has been conducted annually in China. Samples have been collected from environments including live poultry markets, ... Yu Z, et al. PB2 and hemagglutinin mutations confer a virulent phenotype on an H1N2 avian influenza virus in mice. Arch Virol. 2019 May 20. Abstract
submitted by kickingbird at May, 23, 2019 from Arch Virol. 2019 May 20 (via https://link.springer.com/article/10.1007%2Fs00705-019-04283)
We previously obtained mouse-adapted variants of H1N2 avian influenza virus that contained PB2-L134H, PB2-I647L, PB2-D701N, HA-G228S, and M1-D231N mutations. Here, we analyzed the effects of these mutations ... Carvalho SB, et al. Membrane-based approach for the downstream processing of influenza virus-like particles. Biotechnol J. 2019 May 20:e201800570. Abstract
submitted by kickingbird at May, 22, 2019 from Biotechnol J. 2019 May 20:e201800570 (via https://onlinelibrary.wiley.com/doi/abs/10.1002/biot.2018005)
Currently marketed influenza vaccines are only efficient against homologous viruses, thus requiring a seasonal update based on circulating subtypes. This constant reformulation adds several challenges ... Nishizawa S, et al. Strong binding and off-on signaling functions of deep-red fluorescent TO-PRO-3 for influenza A virus RNA promoter region. Chembiochem. 2019 May 20.. Abstract
submitted by kickingbird at May, 22, 2019 from Chembiochem. 2019 May 20. (via https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.2019003)
Influenza A virus RNA promoter region has recently attracted much attention as RNA targets for the development of novel anti-influenza drugs. However, there are very limited reports on small RNA-binding ... Bajic G, et al. Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope. Cell Host Microbe. 2019 May 14. Abstract
submitted by kickingbird at May, 22, 2019 from Cell Host Microbe. 2019 May 14 (via https://www.ncbi.nlm.nih.gov/pubmed/31104946)
Viral glycoproteins are under constant immune surveillance by a host's adaptive immune responses. Antigenic variation including glycan introduction or removal is among the mechanisms viruses have evolved ... Trigueiro-Louro JM, et al. To hit or not to hit: Large-scale sequence analysis and structure characterization of influenza A NS1 unlocks new antiviral target potential. Virology. 2019 Apr 27.. Abstract
submitted by kickingbird at May, 22, 2019 from Virology. 2019 Apr 27. (via https://www.sciencedirect.com/science/article/abs/pii/S00426)
Influenza NS1 protein is among the most promising novel druggable anti-influenza target, based on its structure; multiple interactions; and global function in influenza replication and pathogenesis. Notwithstanding, ... Wu JY, et al. Transmission Risk of Avian Influenza Virus along Poultry Supply Chains in Guangdong, China. J Infect. 2019 May 14.. Abstract
submitted by kickingbird at May, 20, 2019 from J Infect. 2019 May 14. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
OBJECTIVES: Avian influenza viruses (AIVs) poise significant risk to human health and the poultry industry. We evaluated the transmission risk along the poultry supply chain.METHODS: During October 2015 ... Zhang W, et al. A hospital cluster combined with a family cluster of avian influenza H7N9 infection in Anhui Province, China. J Infect. 2019 May 14.. Abstract
submitted by kickingbird at May, 20, 2019 from J Infect. 2019 May 14. (via https://www.journalofinfection.com/article/S0163-4453(19)301)
OBJECTIVES: To identify human-to-human transmission of H7N9 avian influenza virus, we investigated a hospital cluster combined with family cluster in this study.METHODS: We obtained and analyzed clinical, ... 6896 items, 20/Page, Page[188/345][|<<] [|<] [181] [182] [183] [184] [185] [186] [187] [188] [189] [190] [>|] [>>|] |
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