Hu M, Yang G, DeBeauchamp J, et al. HA Stabilization Promotes Replication and Transmission of Swine H1N1 Gamma Influenza Viruses in Ferrets. Elife. 2020;9:e56236.. Abstract
submitted by kickingbird at Jul, 2, 2020 from Elife. 2020;9:e56236. (via https://pubmed.ncbi.nlm.nih.gov/32602461/)
Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits ... Hu Z, Shi L, Xu N, et al. Induction of Cross-Group Broadly Reactive Antibody Response by Natural H7N9 Avian Influenza Virus Infection and Immunization With Inactivated H7N9 Vaccine in Chickens. Transbound Emerg Dis. 2020;10.1111/tbed.13705. Abstract
submitted by kickingbird at Jul, 2, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13705 (via https://pubmed.ncbi.nlm.nih.gov/32602258/)
Pre-existing immunity against the conserved hemagglutinin (HA) stalk underlies the elicitation of cross-group antibody induced by natural H7N9 virus infection and immunization in humans. However, whether ... Park JK, Xiao Y, Ramuta MD, et al. Pre-existing Immunity to Influenza Virus Hemagglutinin Stalk Might Drive Selection for Antibody-Escape Mutant Viruses in a Human Challenge Model. Nat Med. 2020;10.1038/s41591-020-0937-x. Abstract
submitted by kickingbird at Jul, 2, 2020 from Nat Med. 2020;10.1038/s41591-020-0937-x (via https://pubmed.ncbi.nlm.nih.gov/32601336/)
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1-5. Although the HA stalk region is relatively well conserved, ... Le Sage V, Kanarek JP, Snyder DJ, Cooper VS, Lakda. Mapping of Influenza Virus RNA-RNA Interactions Reveals a Flexible Network. Cell Rep. 2020;31(13):107823. Abstract
submitted by kickingbird at Jul, 2, 2020 from Cell Rep. 2020;31(13):107823 (via https://pubmed.ncbi.nlm.nih.gov/32610124/)
Selective assembly of influenza virus segments into virions is proposed to be mediated through intersegmental RNA-RNA interactions. Here, we developed a method called 2CIMPL that includes proximity ligation ... Ruan T, Sun J, Liu W, et al. H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells. Cell Rep. 2020;31(13):107801. Abstract
submitted by kickingbird at Jul, 2, 2020 from Cell Rep. 2020;31(13):107801
Influenza A virus (IAV) primarily infects the airway and alveolar epithelial cells and disrupts the intercellular junctions, leading to increased paracellular permeability. Although this pathological change ... Sevy AM, Gilchuk IM, Brown BP, et al. Computationally Designed Cyclic Peptides Derived From an Antibody Loop Increase Breadth of Binding for Influenza Variants. Structure. 2020;S0969-2126(20)30124-6. Abstract
submitted by kickingbird at Jul, 2, 2020 from Structure. 2020;S0969-2126(20)30124-6 (via https://pubmed.ncbi.nlm.nih.gov/32610044/)
The influenza hemagglutinin (HA) glycoprotein is the target of many broadly neutralizing antibodies. However, influenza viruses can rapidly escape antibody recognition by mutation of hypervariable regions ... Jansen AJG, Spaan T, Low HZ, et al. Influenza-induced Thrombocytopenia Is Dependent on the Subtype and Sialoglycan Receptor and Increases With Virus Pathogenicity. Blood Adv. 2020;4(13):2967-2978. Abstract
submitted by kickingbird at Jul, 2, 2020 from Blood Adv. 2020;4(13):2967-2978 (via https://pubmed.ncbi.nlm.nih.gov/32609845/)
Thrombocytopenia is a common complication of influenza virus infection, and its severity predicts the clinical outcome of critically ill patients. The underlying cause(s) remain incompletely understood. ... HL Sun, et al. Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection. PNAS first published June 29, 2020. Abstract
submitted by kickingbird at Jun, 30, 2020 from PNAS first published June 29, 2020 (via https://www.pnas.org/content/early/2020/06/23/1921186117)
Pigs are considered as important hosts or “mixing vessels” for the generation of pandemic influenza viruses. Systematic surveillance of influenza viruses in pigs is essential for early warning and preparedness ... Zhu Y, Wang R, Yu L, et al. Human TRA2A Determines Influenza A Virus Host Adaptation by Regulating Viral mRNA Splicing. Sci Adv. 2020;6(25):eaaz5764. Abstract
submitted by kickingbird at Jun, 30, 2020 from Sci Adv. 2020;6(25):eaaz5764 (via https://pubmed.ncbi.nlm.nih.gov/32596447/)
Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host ... Zu S, Xue Q, He Z, et al. Duck PIAS2 Promotes H5N1 Avian Influenza Virus Replication Through Its SUMO E3 Ligase Activity. Front Microbiol. 2020;11:1246. Abstract
submitted by kickingbird at Jun, 30, 2020 from Front Microbiol. 2020;11:1246 (via https://pubmed.ncbi.nlm.nih.gov/32595623/)
The protein inhibitor of the activated STAT2 (PIAS2) has been implicated in many cellular processes and can also regulate viral replication in mammals. However, the role of PIAS2 in the highly pathogenic ... McCuen MM, Pitesky ME, Buler JJ, et al. A Comparison of Amplification Methods to Detect Avian Influenza Viruses in California Wetlands Targeted via Remote Sensing of Waterfowl. Transbound Emerg Dis. 2020;10.1111/tbed.13612. Abstract
submitted by kickingbird at Jun, 30, 2020 from Transbound Emerg Dis. 2020;10.1111/tbed.13612 (via https://pubmed.ncbi.nlm.nih.gov/32592444/)
Migratory waterfowl, including geese and ducks, are indicated as the primary reservoir of avian influenza viruses (AIv) which can be subsequently spread to commercial poultry. The US Department of Agriculture's ... Zhang Y, Zhang HX, Zheng Q. In Silico Study of Membrane Lipid Composition Regulating Conformation and Hydration of Influenza Virus B M2 Channel. J Chem Inf Model. 2020;10.1021/acs.jcim.0c00329. Abstract
submitted by kickingbird at Jun, 27, 2020 from J Chem Inf Model. 2020;10.1021/acs.jcim.0c00329 (via https://pubmed.ncbi.nlm.nih.gov/32589410/)
The proton conduction of transmembrane influenza virus B M2 (BM2) proton channel is possibly mediated by the membrane environment, but the detailed molecular mechanism is challenging to determine. In this ... Hao W, Wang L, Li S. FKBP5 Regulates RIG-I-Mediated NF-κB Activation and Influenza A Virus Infection. Viruses. 2020;12(6):E672. Abstract
submitted by kickingbird at Jun, 26, 2020 from Viruses. 2020;12(6):E672 (via https://pubmed.ncbi.nlm.nih.gov/32580383/)
Influenza A virus (IAV) is a highly transmissible respiratory pathogen and is a constant threat to global health with considerable economic and social impact. Influenza viral RNA is sensed by host pattern ... Giotis ES. Inferring the Urban Transmission Potential of Bat Influenza Viruses. Front Cell Infect Microbiol. 2020;10:264. Abstract
submitted by kickingbird at Jun, 26, 2020 from Front Cell Infect Microbiol. 2020;10:264 (via https://pubmed.ncbi.nlm.nih.gov/32582567/)
Bats are considered natural reservoirs of various, potentially zoonotic viruses, exemplified by the influenza A-like viruses H17N10 and H18N11 in asymptomatic Neotropical bats. These influenza viruses ... Lin RJ, Huang CH, Liu PC, et al. Zinc Finger Protein ZFP36L1 Inhibits Influenza A Virus Through Translational Repression by Targeting HA, M and NS RNA Transcripts. Nucleic Acids Res. 2020;gkaa458. Abstract
submitted by kickingbird at Jun, 25, 2020 from Nucleic Acids Res. 2020;gkaa458 (via https://pubmed.ncbi.nlm.nih.gov/32556261/)
ZFP36L1, a CCCH-type zinc finger protein, is an RNA-binding protein that participates in controlling cellular mRNA abundance and turnover by posttranscriptional regulation. Here, we demonstrated that ZFP36L1 ... Wu NC, Thompson AJ, Lee JM, et al. Different Genetic Barriers for Resistance to HA Stem Antibodies in Influenza H3 and H1 Viruses. Science. 2020;368(6497):1335-1340. Abstract
submitted by kickingbird at Jun, 25, 2020 from Science. 2020;368(6497):1335-1340 (via https://pubmed.ncbi.nlm.nih.gov/32554590/)
The discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal ... Qin Z, Qu X, Lei L, Xu L, Pan Z. Y-Box-Binding Protein 3 (YBX3) Restricts Influenza A Virus by Interacting With Viral Ribonucleoprotein Complex and Imparing Its Function. J Gen Virol. 2020;101(4):385-398.. Abstract
submitted by kickingbird at Jun, 25, 2020 from J Gen Virol. 2020;101(4):385-398. (via https://pubmed.ncbi.nlm.nih.gov/32553055/)
The influenza A virus (IAV) ribonucleoprotein (vRNP) complex consists of polymerase subunits, nucleoprotein (NP) and viral RNA and is responsible for RNA transcription and replication. Interactions between ... Sun N, Jiang L, Ye M, et al. TRIM35 Mediates Protection Against Influenza Infection by Activating TRAF3 and Degrading Viral PB2. Protein Cell. 2020;10.1007/s13238-020-00734-6. Abstract
submitted by kickingbird at Jun, 25, 2020 from Protein Cell. 2020;10.1007/s13238-020-00734-6 (via https://pubmed.ncbi.nlm.nih.gov/32562145/)
Tripartite motif (TRIM) family proteins are important effectors of innate immunity against viral infections. Here we identified TRIM35 as a regulator of TRAF3 activation. Deficiency in or inhibition of ... Podshivalov DD, Kirilin EM, Konnov SI, ?vedas VK. Structural Organization and Dynamic Characteristics of the Binding Site for Conformational Rearrangement Inhibitors in Hemagglutinins From H3N2 and H7N9 Influenza Viruses. Biochemistry (Mosc). 2020;85(4):499-506. Abstract
submitted by kickingbird at Jun, 25, 2020 from Biochemistry (Mosc). 2020;85(4):499-506 (via https://pubmed.ncbi.nlm.nih.gov/32569557/)
Computer models of hemagglutinins from the H3N2 and H7N9 influenza viruses were developed to study structural organization and dynamic characteristics of the binding site for the conformational rearrangement ... Bhat S, Bialy D, Sealy JE, Sadeyen JR, Chang P, Iq. A Ligation and Restriction Enzyme Independent Cloning Technique: An Alternative to Conventional Methods for Cloning Hard-To-Clone Gene Segments in the Influenza Reverse Genetics System. Virol J. 2020;17(1):82. Abstract
submitted by kickingbird at Jun, 25, 2020 from Virol J. 2020;17(1):82 (via https://pubmed.ncbi.nlm.nih.gov/32576218/)
Background: Reverse genetics is used in many laboratories around the world and enables the creation of tailor-made influenza viruses with a desired genotype or phenotype. However, the process is not flawless, ... 6896 items, 20/Page, Page[164/345][|<<] [|<] [161] [162] [163] [164] [165] [166] [167] [168] [169] [170] [>|] [>>|] |
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