Guilfoyle K, Major D, Skeldon S, James H, Tingsted. Protective efficacy of a polyvalent influenza A DNA vaccine against both homologous (H1N1pdm09) and heterologous (H5N1) challenge in the ferret model. Vaccine. 2020 Oct 6:S0264-410X(20)31233-0. Abstract
submitted by kickingbird at Oct, 12, 2020 from Vaccine. 2020 Oct 6:S0264-410X(20)31233-0 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
This study describes the protective efficacy of a novel influenza plasmid DNA vaccine in the ferret challenge model. The rationally designed polyvalent influenza DNA vaccine encodes haemagglutinin and ... Brehony C, Dunford L, Bennett C, O´Donnell J. Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season. J Clin Virol. 2020 Oct 1;132:104653. Abstract
submitted by kickingbird at Oct, 12, 2020 from J Clin Virol. 2020 Oct 1;132:104653 (via https://www.sciencedirect.com/science/article/pii/S138665322)
Neuraminidase inhibitor (NAI) resistance levels globally are currently low. However, as antivirals are increasingly being used, and even in the absence of selective pressure, resistance may increase or ... Arai Y, Kawashita N, Elgendy EM, Ibrahim MS, Daido. PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range. J Virol. 2020 Oct 7:JVI.01582-20. Abstract
submitted by kickingbird at Oct, 11, 2020 from J Virol. 2020 Oct 7:JVI.01582-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01582-20)
Adaptive mutations and/or reassortments in avian influenza virus polymerase subunits PA, PB1 and PB2 are one of the major factors enabling the virus to overcome the species barrier to infect humans. The ... Wei Y, Zeng Y, Zhang X, Xu S, Wang Z, Du Y, Zhang. The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. J Virol. 2020 Oct 7:JVI.01640-20. Abstract
submitted by kickingbird at Oct, 11, 2020 from J Virol. 2020 Oct 7:JVI.01640-20 (via https://jvi.asm.org/content/early/2020/10/02/JVI.01640-20)
H7N9 influenza A virus (IAV) is an emerged contagious pathogen that may cause severe human infections, even death. Understanding the precise cross-talk between virus and host is vital for the development ... Laleye AT, Abolnik C. Emergence of highly pathogenic H5N2 and H7N1 influenza A viruses from low pathogenic precursors by serial passage in ovo. PLoS One. 2020 Oct 8;15(10):e0240290. Abstract
submitted by kickingbird at Oct, 11, 2020 from PLoS One. 2020 Oct 8;15(10):e0240290 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Highly pathogenic (HPAI) strains emerge from their low pathogenic (LPAI) precursors and cause severe disease in poultry with enormous economic losses, and zoonotic potential. Understanding the mechanisms ... Herfst S, Zhang J, Richard M, McBride R, Lexmond P. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host Microbe. 2020 Oct 7;28(4):602-613.e7. Abstract
submitted by kickingbird at Oct, 11, 2020 from Cell Host Microbe. 2020 Oct 7;28(4):602-613.e7 (via https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(2)
In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission ... Chu HY, Boeckh M, Englund JA, Famulare M, Lutz B,. The Seattle Flu Study: a multiarm community-based prospective study protocol for assessing influenza prevalence, transmission and genomic epidemiology. BMJ Open. 2020 Oct 7;10(10):e037295. Abstract
submitted by kickingbird at Oct, 11, 2020 from BMJ Open. 2020 Oct 7;10(10):e037295 (via https://bmjopen.bmj.com/content/10/10/e037295)
Introduction: Influenza epidemics and pandemics cause significant morbidity and mortality. An effective response to a potential pandemic requires the infrastructure to rapidly detect, characterise, and ... Gulyaeva M, Huettmann F, Shestopalov A, Okamatsu M. Data mining and model-predicting a global disease reservoir for low-pathogenic Avian Influenza (A) in the wider pacific rim using big data sets. Sci Rep. 2020 Oct 8;10(1):16817. Abstract
submitted by kickingbird at Oct, 11, 2020 from Sci Rep. 2020 Oct 8;10(1):16817 (via https://www.nature.com/articles/s41598-020-73664-2)
Avian Influenza (AI) is a complex but still poorly understood disease; specifically when it comes to reservoirs, co-infections, connectedness and wider landscape perspectives. Low pathogenic (Low-path ... Zhang C, Wang Y, Chen C, Long H, Bai J, Zeng J, Ca. A Mutation Network Method for Transmission Analysis of Human Influenza H3N2. Viruses. 2020 Oct 3;12(10):E1125. Abstract
submitted by kickingbird at Oct, 8, 2020 from Viruses. 2020 Oct 3;12(10):E1125 (via https://www.mdpi.com/1999-4915/12/10/1125)
Characterizing the spatial transmission pattern is critical for better surveillance and control of human influenza. Here, we propose a mutation network framework that utilizes network theory to study the ... Jiang H, Peng W, Qi J, Chai Y, Song H, Bi Y, Rijal. Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus. mBio. 2020 Oct 6;11(5):e02315-20. Abstract
submitted by kickingbird at Oct, 8, 2020 from mBio. 2020 Oct 6;11(5):e02315-20 (via https://mbio.asm.org/content/11/5/e02315-20)
Here, we investigate a monoclonal antibody, Z2B3, isolated from an H7N9-infected patient, that exhibited cross-reactivity to both N9 (group 2) and a broad range of seasonal and avian N1 (group 1) proteins ... Hu J, Zhang L, Liu X. Role of Post-translational Modifications in Influenza A Virus Life Cycle and Host Innate Immune Response. Front Microbiol. 2020 Sep 4;11:517461. Abstract
submitted by kickingbird at Oct, 6, 2020 from Front Microbiol. 2020 Sep 4;11:517461 (via https://www.frontiersin.org/articles/10.3389/fmicb.2020.5174)
Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system. During infection, influenza virus ... Li Y, Chai W, Min J, Ye Z, Tong X, Qi D, Liu W, Lu. Neddylation of M1 negatively regulates the replication of influenza A virus. J Gen Virol. 2020 Oct 5. Abstract
submitted by kickingbird at Oct, 6, 2020 from J Gen Virol. 2020 Oct 5 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Post-translational modification plays a critical role in viral replication. Previously we reported that neddylation of PB2 of influenza A virus (IAV) can inhibit viral replication. However, we found that ... Kim HR, An S, Hwang J. An integrated system of air sampling and simultaneous enrichment for rapid biosensing of airborne coronavirus and influenza virus. Biosens Bioelectron. 2020 Sep 26;170:112656. Abstract
submitted by kickingbird at Oct, 5, 2020 from Biosens Bioelectron. 2020 Sep 26;170:112656 (via https://www.sciencedirect.com/science/article/pii/S095656632)
Point-of-care risk assessment (PCRA) for airborne viruses requires a system that can enrich low-concentration airborne viruses dispersed in field environments into a small volume of liquid. In this study, ... Nissly RH, Zaman N, Ibrahim PAS, McDaniel K, Lim L. Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD): Emerging role of orthomyxoviruses in the pathogenesis of BRD. Virology. 2020 Sep 26;551:10-15. Abstract
submitted by kickingbird at Oct, 5, 2020 from Virology. 2020 Sep 26;551:10-15 (via https://www.sciencedirect.com/science/article/pii/S004268222)
Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to ... Nelson MI, Perofsky A, McBride DS, Rambo-Martin BL. A heterogenous swine show circuit drives zoonotic transmission of influenza A viruses in the United States. J Virol. 2020 Sep 30:JVI.01453-20. Abstract
submitted by kickingbird at Oct, 3, 2020 from J Virol. 2020 Sep 30:JVI.01453-20 (via https://jvi.asm.org/content/early/2020/09/24/JVI.01453-20)
Influenza pandemics are associated with severe morbidity, mortality, and social and economic disruption. Every summer in the United States, youths attending agricultural fairs are exposed to genetically ... Selzer L, Su Z, Pintilie GD, Chiu W, Kirkegaard K. Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer. PLoS Biol. 2020 Sep 30;18(9):e3000827. Abstract
submitted by kickingbird at Oct, 3, 2020 from PLoS Biol. 2020 Sep 30;18(9):e3000827 (via https://pubmed.ncbi.nlm.nih.gov/32997652/)
Matrix proteins are encoded by many enveloped viruses, including influenza viruses, herpes viruses, and coronaviruses. Underneath the viral envelope of influenza virus, matrix protein 1 (M1) forms an oligomeric ... Soda K, Kashiwabara M, Miura K, Ung TTH, Nguyen HL. Characterization of H3 subtype avian influenza viruses isolated from poultry in Vietnam. Virus Genes. 2020 Sep 29. Abstract
submitted by kickingbird at Oct, 3, 2020 from Virus Genes. 2020 Sep 29 (via https://pubmed.ncbi.nlm.nih.gov/32996077/)
To date, avian influenza viruses (AIVs) have persisted in domestic poultry in wet markets in East Asian countries. We have performed ongoing virus surveillance in poultry populations in Vietnam since 2011, ... Zhao L, Xia H, Huang J, Zheng Y, Liu C, Su J, Ping. Features of Nuclear Export Signals of NS2 Protein of Influenza D Virus. Viruses. 2020 Sep 29;12(10):E1100. Abstract
submitted by kickingbird at Oct, 3, 2020 from Viruses. 2020 Sep 29;12(10):E1100 (via https://www.mdpi.com/1999-4915/12/10/1100)
Emerging influenza D viruses (IDVs), the newest member in the genus Orthomyxovirus family, which can infect and transmit in multiple mammalian species as its relatives the influenza A viruses (IAVs). Additional ... Madsen A, Dai YN, McMahon M, Schmitz AJ, Turner JS. Human Antibodies Targeting Influenza B Virus Neuraminidase Active Site Are Broadly Protective. Immunity. 2020 Sep 22:S1074-7613(20)30372-1. Abstract
submitted by kickingbird at Sep, 28, 2020 from Immunity. 2020 Sep 22:S1074-7613(20)30372-1 (via https://www.cell.com/immunity/fulltext/S1074-7613(20)30372-1)
nfluenza B virus (IBV) infections can cause severe disease in children and the elderly. Commonly used antivirals have lower clinical effectiveness against IBV compared to influenza A viruses (IAV). Neuraminidase ... Mooij P, Mortier D, Stammes M, Fagrouch Z, Verscho. Aerosolized pH1N1 influenza infection induces less systemic and local immune activation in the lung than combined intrabronchial, nasal and oral exposure in cynomolgus macaques. J Gen Virol. 2020 Sep 25. Abstract
submitted by kickingbird at Sep, 28, 2020 from J Gen Virol. 2020 Sep 25 (via https://www.microbiologyresearch.org/content/journal/jgv/10.)
Non-human primates form an important animal model for the evaluation of immunogenicity and efficacy of novel 'universal' vaccine candidates against influenza virus. However, in most studies a combination ... 6896 items, 20/Page, Page[158/345][|<<] [|<] [151] [152] [153] [154] [155] [156] [157] [158] [159] [160] [>|] [>>|] |
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