Liu Y, Fu C, Ye S, Liang Y, Qi Z, Yao C, Wang Z, W. The inactivated vaccine of reassortant H3N2 canine influenza virus based on internal gene cassette from PR8 is safe and effective. Vet Microbiol. 2021 Jan 27;254:108997. Abstract
submitted by kickingbird at Feb, 2, 2021 from Vet Microbiol. 2021 Jan 27;254:108997 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Canine influenza (CI) is a contagious respiratory disease in dogs, which poses a threat to canine health. A safe, high-yield vaccine seed virus is critical for CI vaccine development. We developed a PR8-based ... Mohd-Kipli F, Claridge JK, Habjani? J, Jiang A, Sc. Conformational triggers associated with influenza matrix protein 1 polymerization. J Biol Chem. 2021 Jan 28:100316. Abstract
submitted by kickingbird at Feb, 1, 2021 from J Biol Chem. 2021 Jan 28:100316 (via https://www.jbc.org/article/S0021-9258(21)00086-7/fulltext)
A central role for the influenza matrix protein 1 (M1) is to form a polymeric coat on the inner leaflet of the host membrane that ultimately provides shape and stability to the virion. M1 polymerizes upon ... Shi N, Zhang S, Guo Y, Yu X, Zhao W, Zhang M, Guan. CircRNA_0050463 promotes influenza A virus replication by sponging miR-33b-5p to regulate EEF1A1. Vet Microbiol. 2021 Jan 19;254:108995. Abstract
submitted by kickingbird at Feb, 1, 2021 from Vet Microbiol. 2021 Jan 19;254:108995 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Circular RNAs (circRNAs), a new class of widely expressed endogenous regulatory RNAs, are characterized by a covalently closed loop structure without a 5' cap or 3' tail. Increasing numbers of studies ... Tang W, Li X, Tang L, Wang T, He G. Characterization of the low-pathogenic H7N7 avian influenza virus in Shanghai, China. Poult Sci. 2021 Feb;100(2):565-574. Abstract
submitted by kickingbird at Feb, 1, 2021 from Poult Sci. 2021 Feb;100(2):565-574 (via https://www.sciencedirect.com/science/article/pii/S003257912)
H7N7 avian influenza virus (AIV) can divided into low-pathogenic AIV and high-pathogenic AIV groups. It has been shown to infect humans and animals. Its prevalence state in wild birds in China remains ... Wang G, Liu D, Hu J, Gu M, Wang X, He D, Zhang L,. Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice. Vet Microbiol. 2021 Jan 20;254:109000. Abstract
submitted by kickingbird at Feb, 1, 2021 from Vet Microbiol. 2021 Jan 20;254:109000 (via https://www.sciencedirect.com/science/article/pii/S037811352)
The first avian H7N9 influenza outbreak in spring of 2013 emerged in an unprecedented transmission from infected poultry to humans in the Yangtze delta area, eastern China, posing a dual challenge to public ... Wu Y, Bissinger T, Genzel Y, Liu X, Reichl U, Tan. High cell density perfusion process for high yield of influenza A virus production using MDCK suspension cells. Appl Microbiol Biotechnol. 2021 Jan 30. Abstract
submitted by kickingbird at Jan, 31, 2021 from Appl Microbiol Biotechnol. 2021 Jan 30 (via https://link.springer.com/article/10.1007/s00253-020-11050-8)
Similar to the recent COVID-19 pandemic, influenza A virus poses a constant threat to the global community. For the treatment of flu disease, both antivirals and vaccines are available with vaccines the ... Li X, Zhang L, Liu Y, Ma L, Zhang N, Xia C. Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope. J Biol Chem. 2020 Apr 17;295(16):5292-5306. Abstract
submitted by kickingbird at Jan, 30, 2021 from J Biol Chem. 2020 Apr 17;295(16):5292-5306 (via https://www.jbc.org/article/S0021-9258(17)48550-4/fulltext)
Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes ... Levene RE, Shrestha SD, Gaglia MM. The influenza A virus host shutoff factor PA-X is rapidly turned over in a strain-specific manner. J Virol. 2021 Jan 27:JVI.02312-20.. Abstract
submitted by kickingbird at Jan, 29, 2021 from J Virol. 2021 Jan 27:JVI.02312-20. (via https://jvi.asm.org/content/early/2021/01/25/JVI.02312-20)
The influenza A endoribonuclease PA-X regulates virulence and transmission of the virus by reducing host gene expression and thus regulating immune responses to influenza A virus. Despite this key function ... McBride DS, Lauterbach SE, Li YT, Smith GJD, Killi. Genomic Evidence for Sequestration of Influenza A Virus Lineages in Sea Duck Host Species. Viruses. 2021 Jan 24;13(2):172. Abstract
submitted by kickingbird at Jan, 28, 2021 from Viruses. 2021 Jan 24;13(2):172 (via https://www.mdpi.com/1999-4915/13/2/172)
Wild birds are considered the natural reservoir of influenza A viruses (IAVs) making them critical for IAV surveillance efforts. While sea ducks have played a role in novel IAV emergence events that threatened ... Lei GL, Wang LP, Dong SH, Sun F, Cheng JX, Yang XL. A recombinant influenza virus with a CTLA4-specific scFv inhibits tumor growth in a mouse model. Cell Biol Int. 2021 Jan 26. Abstract
submitted by kickingbird at Jan, 28, 2021 from Cell Biol Int. 2021 Jan 26 (via https://onlinelibrary.wiley.com/doi/10.1002/cbin.11559)
Oncolytic viruses (OV) have shown excellent safety and efficacy in preclinical and clinical studies. Influenza A virus (IAV) is considered a promising oncolytic virus. In this report, we generated a recombinant ... Li Z, Zhao Y, Li Y, Chen X. Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity. Vaccines (Basel). 2021 Jan 21;9(2):75. Abstract
submitted by kickingbird at Jan, 27, 2021 from Vaccines (Basel). 2021 Jan 21;9(2):75 (via https://www.mdpi.com/2076-393X/9/2/75)
Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies ... Luczo JM, Ronzulli SL, Tompkins SM. Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30. Viruses. 2021 Jan 21;13(2):156. Abstract
submitted by kickingbird at Jan, 27, 2021 from Viruses. 2021 Jan 21;13(2):156 (via https://www.mdpi.com/1999-4915/13/2/156)
Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors ... Borchering RK, Gunning CE, Gokhale DV, Weedop KB,. Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123. Abstract
submitted by kickingbird at Jan, 27, 2021 from Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e20123 (via https://www.pnas.org/content/118/5/e2012327118)
The 2019/2020 influenza season in the United States began earlier than any season since the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as August. Also noteworthy ... Briand FX, Niqueux E, Schmitz A, Martenot C, Cherb. Highly Pathogenic Avian Influenza A(H5N8) Virus Spread by Short- and Long-Range Transmission, France, 2016-17. Emerg Infect Dis. 2021 Feb;27(2):508-516. Abstract
submitted by kickingbird at Jan, 27, 2021 from Emerg Infect Dis. 2021 Feb;27(2):508-516 (via https://wwwnc.cdc.gov/eid/article/27/2/20-2920_article)
We detected 3 genotypes of highly pathogenic avian influenza A(H5N8) virus in France during winter 2016-17. Genotype A viruses caused dramatic economic losses in the domestic duck farm industry in southwestern ... Harshbarger WD, Deming D, Lockbaum GJ, Attatippaho. Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nat Commun. 2021 Jan 25;12(1):559. Abstract
submitted by kickingbird at Jan, 27, 2021 from Nat Commun. 2021 Jan 25;12(1):559 (via https://www.nature.com/articles/s41467-020-20879-6)
Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report ... Bantle CM, French CT, Cummings JE, Sadasivan S, Tr. Manganese exposure in juvenile C57BL/6 mice increases glial inflammatory responses in the substantia nigra following infection with H1N1 influenza virus. PLoS One. 2021 Jan 25;16(1):e0245171. Abstract
submitted by kickingbird at Jan, 26, 2021 from PLoS One. 2021 Jan 25;16(1):e0245171 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration. Post-encephalitic parkinsonism has been reported ... Brázda V, Porubiaková O, Cantara A, Bohálová N, Co. G-quadruplexes in H1N1 influenza genomes. BMC Genomics. 2021 Jan 23;22(1):77. Abstract
submitted by kickingbird at Jan, 26, 2021 from BMC Genomics. 2021 Jan 23;22(1):77 (via https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286)
Background: Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investigated ... Cao L, Lou J, Zhao S, Chan RWY, Chan M, Wu WKK, Ch. In silico prediction of influenza vaccine effectiveness by sequence analysis. Vaccine. 2021 Jan 19:S0264-410X(21)00006-2. Abstract
submitted by kickingbird at Jan, 24, 2021 from Vaccine. 2021 Jan 19:S0264-410X(21)00006-2 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
The effectiveness of seasonal influenza vaccines varies with the matching of vaccine strains to circulating strains. Based on the genetic distance of hemagglutinin and neuraminidase gene of the influenza ... Zhang C, Cui H, Wang Z, Dong S, Zhang C, Li J, Men. Pathogenicity and transmissibility assessment of two strains of human influenza virus isolated in China in 2018. J Int Med Res. 2021 Jan;49(1):300060520982832. Abstract
submitted by kickingbird at Jan, 23, 2021 from J Int Med Res. 2021 Jan;49(1):300060520982832 (via https://journals.sagepub.com/doi/10.1177/0300060520982832)
Objective: Influenza season occurs every year in China, but its presentation was unusual in the period from December 2017 to early 2018. During this period, influenza activity was increasing across the ... Zhang Y, Zheng QC. In Silico Analysis Revealed a Unique Binding but Ineffective Mode of Amantadine to Influenza Virus B M2 Channel. J Phys Chem Lett. 2021 Jan 22:1169-1174. Abstract
submitted by kickingbird at Jan, 23, 2021 from J Phys Chem Lett. 2021 Jan 22:1169-1174 (via https://pubs.acs.org/doi/10.1021/acs.jpclett.0c03560)
The M2 proton channel of influenza A (AM2) and B (BM2) have a highly conserved function motif, considered as the effective target. As yet, there is no effective drug against BM2. Research showed that AM2 ... 6896 items, 20/Page, Page[152/345][|<<] [|<] [151] [152] [153] [154] [155] [156] [157] [158] [159] [160] [>|] [>>|] |
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