Kirchenbaum GA, Allen JD, Layman TS, Sautto GA, et. Infection of Ferrets with Influenza Virus Elicits a Light Chain-Biased Antibody Response against Hemagglutinin. J Immunol 2017 Oct 27. Abstract
submitted by kickingbird at Nov, 6, 2017 from J Immunol 2017 Oct 27 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29079697/)
The domestic ferret (Mustela putorius furo) is a commonly used animal model for the study of influenza virus infection and vaccination. Recently, our group has developed murine mAbs with specificity for ... Gomaa MR, Kandeil A, El-Shesheny R, Shehata MM, et. Evidence of infection with avian, human, and swine influenza viruses in pigs in Cairo, Egypt. Arch Virol 2017 Oct 26. Abstract
submitted by kickingbird at Nov, 6, 2017 from Arch Virol 2017 Oct 26 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29075888/)
The majority of the Egyptian swine population was culled in the aftermath of the 2009 H1N1 pandemic, but small-scale growing remains. We sampled pigs from piggeries and an abattoir in Cairo. We found virological ... Moasser E, Behzadian F, Moattari A, Fotouhi F, et. Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015. Arch Virol 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Arch Virol 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29086107/)
BACKGROUND: Characterization of influenza viruses is critical for detection of new emerging variants. Herein, we analyzed the genetic diversity and drug susceptibility of the neuraminidase gene (NAs) ... Yu Z, Cheng K, Sun W, Zhang X, et al. PB2 and HA mutations increase the virulence of highly pathogenic H5N5 clade 2.3.4.4 avian influenza virus in mice. Arch Virol 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Arch Virol 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29090366/)
H5 clade 2.3.4.4 influenza A viruses pose a potential threat to public health and are a cause of public concern. Here, we generated mouse-adapted viruses of a waterfowl-origin H5N5 virus (H5 clade 2.3.4.4) ... Sarvestani ST, McAuley JL. The role of the NLRP3 inflammasome in regulation of antiviral responses to influenza A virus infection. Antiviral Res 2017 Oct 30. Abstract
submitted by kickingbird at Nov, 6, 2017 from Antiviral Res 2017 Oct 30 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29097227/)
The innate immune system provides the host with both a dynamic barrier to prevent infection and a means to which rapid anti-microbial responses can be mounted. The inflammasome pathway is a critical host ... Marathe BM, Mostafa HH, Vogel P, Pascua PNQ, et al. A pharmacologically immunosuppressed mouse model for assessing influenza B virus pathogenicity and oseltamivir treatment. Antiviral Res 2017 Oct 31. Abstract
submitted by kickingbird at Nov, 6, 2017 from Antiviral Res 2017 Oct 31 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29100887/)
Immunocompromised patients are highly susceptible to influenza virus infections. Although neuraminidase inhibitor (NAI) therapy has proved effective in these patients, the treatment regimens require optimization, ... Beerens N, Heutink R, Bergervoet SA, Harders F, Bo. Multiple Reassorted Viruses as Cause of Highly Pathogenic Avian Influenza A(H5N8) Virus Epidemic, the Netherlands, 2016. Emerg Infect Dis. 2017 Dec. Abstract
submitted by kickingbird at Nov, 4, 2017 from Emerg Infect Dis. 2017 Dec (via https://wwwnc.cdc.gov/eid/article/23/12/17-1062_article)
In 2016, an epidemic of highly pathogenic avian influenza A virus subtype H5N8 in the Netherlands caused mass deaths among wild birds, and several commercial poultry farms and captive bird holdings were ... Xiangjun Du, etc.,al. Evolution-informed forecasting of seasonal influenza A (H3N2). Science Translational Medicine 25 Oct 2017. Abstract
submitted by kickingbird at Nov, 1, 2017 from Science Translational Medicine 25 Oct 2017 (via http://stm.sciencemag.org/content/scitransmed/9/413/eaan5325)
Interpandemic or seasonal influenza A, currently subtypes H3N2 and H1N1, exacts an enormous annual burden both in terms of human health and economic impact. Incidence prediction ahead of season remains ... Ana-Sosa-Batiz F, Johnston APR, Hogarth PM, Wines. Antibody-dependent phagocytosis (ADP) responses following trivalent inactivated influenza vaccination of younger and older adults. Vaccine 2017 Oct 10. Abstract
submitted by kickingbird at Nov, 1, 2017 from Vaccine 2017 Oct 10 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29029940/)
Globally the most commonly utilised immunisation against influenza is the trivalent inactivated influenza vaccine (TIV) derived from an A/H1N1, an A/H3N2 and aB type influenza virus. Vaccine effectiveness ... Buffin S, Ikhelef N, Prudent J, Dubayle J, et al. A latex agglutination assay to quantify the amount of hemagglutinin protein in adjuvanted low-dose influenza monovalent vaccines. J Virol Methods 2017. Abstract
submitted by kickingbird at Nov, 1, 2017 from J Virol Methods 2017 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29030070/)
To formulate inactivated influenza vaccines, the concentration of hemagglutinin (HA) must be accurately determined. The standard test currently used to measure HA in influenza vaccines is the Single Radial ... Jianzhong Shi,etc.,al. H7N9 virulent mutants detected in chickens in China pose an increased threat to humans. Cell Research 24 Oct, 2017. Abstract
submitted by kickingbird at Oct, 31, 2017 from Cell Research 24 Oct, 2017 (via https://www.nature.com/cr/journal/vaop/ncurrent/full/cr20171)
Certain low pathogenic avian influenza viruses can mutate to highly pathogenic viruses when they circulate in domestic poultry, at which point they can cause devastating poultry diseases and severe economic ... M Imai,etc.,al. A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets. Cell Host & Microbe. Abstract
submitted by kickingbird at Oct, 23, 2017 from Cell Host & Microbe (via http://www.cell.com/cell-host-microbe/fulltext/S1931-3128%28)
Highly pathogenic avian influenza (HPAI) H7N9 viruses replicate efficiently in mammals HPAI H7N9 viruses are more pathogenic than low pathogenic H7N9 viruses in mammals HPAI H7N9 viruses transmit ... Bradley JS, Blumer JL, Romero JR, Michaels MG, et. Intravenous Zanamivir in Hospitalized Patients With Influenza. Pediatrics 2017 Oct 19.. Abstract
submitted by kickingbird at Oct, 22, 2017 from Pediatrics 2017 Oct 19. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29051331/)
BACKGROUND: Children with severe influenza infection may require parenteral therapy if oral or inhaled therapies are ineffective or cannot be administered. Results from a study investigating intravenous ... Lion A, Richard M, Esnault E, Kut E, et al. Productive replication of avian influenza viruses in chicken endothelial cells is determined by hemagglutinin cleavability and is related to innate immune escape.. Virology 2017;513:29-42. Abstract
submitted by kickingbird at Oct, 22, 2017 from Virology 2017;513:29-42 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29031164/)
Endotheliotropism is a hallmark of gallinaceous poultry infections with highly pathogenic avian influenza (HPAI) viruses and a feature that distinguishes HPAI from low pathogenic avian influenza (LPAI) ... Frabutt DA, Wang B, Riaz S, Schwartz RC, et al. Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation. J Virol 2017 Oct 18.. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046440/)
Innate immunity provides an immediate defense against infection after host cells sense "danger" signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of misfolded/unfolded proteins ... Sutton TC, Lamirande EW, Bock KW, Moore IN, et al. In vitro neutralization is not predictive of prophylactic efficacy of broadly neutralizing monoclonal antibodies CR6261 and CR9114 against lethal H2 influenza virus challenge in mice. J Virol 2017 Oct 18. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046448/)
Influenza viruses of the H1N1, H2N2, and H3N2 subtypes have caused previous pandemics. H2 influenza viruses represent a pandemic threat due to continued circulation in wild birds and limited immunity in ... Liu H, Grantham ML, Pekosz A. Mutations in the Influenza A virus M1 protein enhance virus budding to complement lethal mutations in the M2 cytoplasmic tail. J Virol 2017 Oct 18. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046451/)
The influenza A virus M1 and M2 proteins play important roles in virus assembly and in the morphology of virus particles. Mutations in the distal cytoplasmic tail region of M2, and in particular a tyrosine ... Choi WS, Jeong JH, Kwon JJ, Ahn SJ, et al. Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6 and N8 Neuraminidase Subtypes. J Virol 2017 Oct 18.. Abstract
submitted by kickingbird at Oct, 22, 2017 from J Virol 2017 Oct 18. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29046464/)
Several subtypes of avian influenza viruses (AIVs) are emerging as novel human pathogens, and the frequency of related infections has increased in recent years. Although neuraminidase (NA) inhibitors (NAIs) ... Gordon NA, McGuire KL, Wallentine SK, Mohl GA, et. Divalent copper complexes as influenza A M2 inhibitors. Antiviral Res 2017;147:100-106. Abstract
submitted by kickingbird at Oct, 22, 2017 from Antiviral Res 2017;147:100-106 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29032206/)
New M2 blockers effective against the ubiquitous amantadine-resistant S31N M2 mutation in influenza A are needed. Six copper complexes, 2, 4, 6, 8, 9, and 10, were synthesized and found to block both wild ... Duh D, Blazic B. Single mutation in the matrix gene of seasonal influenza A viruses critically affects the performance of diagnostic molecular assay. J Virol Methods 2017 Oct 6. Abstract
submitted by kickingbird at Oct, 15, 2017 from J Virol Methods 2017 Oct 6 (via https://www.ncbi.nlm.nih.gov/m/pubmed/28993123/)
Reduced intensity of the fluorescence signal in the amplification curve was observed when using a WHO recommended real time RT-PCR for influenza virus detection. A single mutation, G189T, in the conserved ... 5170 items, 20/Page, Page[151/259][|<<] [|<] [151] [152] [153] [154] [155] [156] [157] [158] [159] [160] [>|] [>>|] |
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