Anika John, etc.,al. Characterizing Influenza A Virus Lineages and Clinically Relevant Mutations Through High-Coverage Wastewater Sequencing. Water Research. 21 Aug 2025, 124453. Abstract
submitted by kickingbird at Aug, 24, 2025 from Water Research. 21 Aug 2025, 124453 (via https://www.sciencedirect.com/science/article/pii/S004313542)
Influenza A virus poses significant public health challenges, causing seasonal outbreaks and pandemics. Its rapid evolution motivates continuous monitoring of circulating influenza genomes to inform vaccine ... Paran, N., Wirblich, C., Olal, C. et al. Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle. npj Vaccines 10, 197 (2025). Abstract
submitted by kickingbird at Aug, 24, 2025 from npj Vaccines 10, 197 (2025) (via https://link.springer.com/article/10.1038/s41541-025-01238-2)
The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based ... Hu, M., Luo, N., Wang, B. et al. Flu-CNN: identifying host specificity of Influenza A virus using convolutional networks. Hum Genomics 19, 96 (2025). Abstract
submitted by kickingbird at Aug, 24, 2025 from Hum Genomics 19, 96 (2025) (via https://link.springer.com/article/10.1186/s40246-025-00812-y)
Influenza A viruses (IAVs) have historically posed significant public health threats, causing severe pandemics. Viral host specificity is typically constrained by host barriers, limiting the range of species ... Arroyave A, Rabezanahary H, Wantchecon A, Rahajama. Assessment of Cross-Reactive Neutralizing Antibodies Induction Against H5N1 Clade 2.3.4.4b by Prior Seasonal Influenza Immunization in Retail Workers. Open Forum Infect Dis. 2025 Aug 20;12(8):ofaf463. Abstract
submitted by kickingbird at Aug, 23, 2025 from Open Forum Infect Dis. 2025 Aug 20;12(8):ofaf463 (via https://academic.oup.com/ofid/article/12/8/ofaf463/8238501)
This study evaluated whether immunity from seasonal influenza induces cross-reactive antibodies against recent avian and bovine H5N1 strains in serum from retail workers. Despite strong neutralizing activity ... Ramya S. Barre, etc.,al. A Human H5N1 Influenza Virus Expressing Bioluminescence for Evaluating Viral Infection and Identifying Therapeutic Interventions. iScience. 21 Aug 2025, 113402. Abstract
submitted by kickingbird at Aug, 23, 2025 from iScience. 21 Aug 2025, 113402 (via https://www.sciencedirect.com/science/article/pii/S258900422)
A multistate outbreak of highly pathogenic avian influenza virus (HPAIV) H5N1 in the United States dairy cattle was first reported on March 2024, followed by a zoonotic cattle-to-human virus transmission ... Rehman, S., Ullah, S., Zaman, A., Ashraf, U., Mali. Tracking the phylogeography of H5N1 Highly pathogenic avian influenza viruses in Indonesia (2003-2024). World’s Poultry Science Journal, 1–23. Abstract
submitted by kickingbird at Aug, 23, 2025 from World’s Poultry Science Journal, 1–23 (via https://www.tandfonline.com/doi/full/10.1080/00439339.2025.2)
Indonesia has experienced HPAI H5N1 outbreaks since 2003, with its first human case detected in 2005. This study investigates the phylogeography and genetic evolution of highly pathogenic avian influenza ... William T. Harvey, etc.,al. [preprint]Genetic reassortment and diversification of host specificity have driven evolutionary trajectories of lineages of panzootic H5N1 influenza. https://doi.org/10.1101/2025.08.20.670882. Abstract
submitted by kickingbird at Aug, 23, 2025 from https://doi.org/10.1101/2025.08.20.670882 (via https://www.biorxiv.org/content/10.1101/2025.08.20.670882v1)
Since 2021, subclade 2.3.4.4b A(H5N1) high pathogenicity avian influenza (HPAI) viruses have undergone changes in ecology and epidemiology, causing a panzootic of unprecedented scale in wild and domestic ... Yin S, Zhang C, Teitelbaum CS, Si Y, Zhang G, Wang. Landscape changes elevate the risk of avian influenza virus diversification and emergence in the East Asian-Australasian Flyway. PNAS 2025 Aug 26;122(34):e2503427122. Abstract
submitted by kickingbird at Aug, 19, 2025 from PNAS 2025 Aug 26;122(34):e2503427122 (via https://www.pnas.org/doi/10.1073/pnas.2503427122)
Highly pathogenic avian influenza viruses (HPAIV) persistently threaten wild waterfowl, domestic poultry, and public health. The East Asian-Australasian Flyway plays a crucial role in HPAIV dynamics due ... Restrepo Munera J, Riccio-Baum C, Kaddis Maldonado. Germinal Center B cells provide essential IL-1β signals to TFH cells via canonical NLRP3 inflammasome activity post influenza infection. PLoS Pathog. 2025 Aug 18;21(8):e1013404. Abstract
submitted by kickingbird at Aug, 19, 2025 from PLoS Pathog. 2025 Aug 18;21(8):e1013404 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Persistent germinal center (GC) responses show increased benefit in optimal responses to influenza infection. Follicular helper T (TFH) cells provide the essential signals and help for maintenance of GCs ... Saeidi S, Wan H, Kang H, Gao J, Wu WW, Malik T, Da. N-linked glycans on the stalk of influenza virus neuraminidase promote functional tetramer formation by compensating for local hydrophobicity. J Virol. 2025 Aug 18:e0087925. Abstract
submitted by kickingbird at Aug, 19, 2025 from J Virol. 2025 Aug 18:e0087925 (via https://journals.asm.org/doi/10.1128/jvi.00879-25)
Enveloped virus surface antigens, such as influenza neuraminidase (NA), typically depend on N-linked glycans for assembly, trafficking in the host cell, and immune evasion. Here, we examined the function ... Basu Thakur P, Bullock HA, Stevens J, Kumar A, Mai. Heterogeneity across mammalian- and avian-origin A(H1N1) influenza viruses influences viral infectivity following incubation with host bacteria from the human respiratory tract. Microbiol Spectr. 2025 Aug 18:e0097725. Abstract
submitted by kickingbird at Aug, 19, 2025 from Microbiol Spectr. 2025 Aug 18:e0097725 (via https://journals.asm.org/doi/10.1128/spectrum.00977-25)
Influenza A viruses (IAVs) are primarily transmitted between mammals by the respiratory route and encounter bacteria in the respiratory tract before infecting susceptible epithelial cells. Previous studies ... Meseko C, Edet UO, Henshaw O, Mkpuma N, Olawuyi KA. Bibliometric analysis of highly pathogenic avian influenza research globally from 2003 to 2023. Germs. 2025 Mar 31;15(1):11-25. Abstract
submitted by kickingbird at Aug, 19, 2025 from Germs. 2025 Mar 31;15(1):11-25 (via https://www.germs.ro/en/Articles/Bibliometric-analysis-of-hi)
Introduction: Despite decades of research on highly pathogenic avian influenza, especially H5N1, an understanding of the impact of research outputs on policy, the impact of funding and policies, collaboration ... Andersen, Hanne et al. Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaques. Immunity. Abstract
submitted by kickingbird at Aug, 19, 2025 from Immunity (via https://www.cell.com/immunity/fulltext/S1074-7613(25)00329-2)
The H5N1 avian influenza virus clade 2.3.4.4b outbreak represents a major pandemic threat for humans, with some reported cases of severe and fatal respiratory illness. A key unanswered question is the ... Ashraf M, Stein AN, Youhanna J, Rockman S, McMahon. The impact of egg adaptation and immune imprinting on influenza vaccine effectiveness. Vaccine. 2025 Aug 13;62:127393. Abstract
submitted by kickingbird at Aug, 18, 2025 from Vaccine. 2025 Aug 13;62:127393 (via https://www.sciencedirect.com/science/article/pii/S0264410X2)
Most influenza vaccines are produced in hens' eggs and may undergo 'egg adaptation', whereby mutations within the haemagglutinin protein that result in adaptation to the avian cells undergo positive selection. ... Rawi R, Morano NC, Cheung CS, Du H, Gorman J, Prab. The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody. Structure. 2025 Aug 6:S0969-2126(25)00264-3. Abstract
submitted by kickingbird at Aug, 18, 2025 from Structure. 2025 Aug 6:S0969-2126(25)00264-3 (via https://www.cell.com/structure/fulltext/S0969-2126(25)00264-)
The N terminus of the H3 subtype of influenza virus hemagglutinin is ～10 residues longer than the N termini of most other hemagglutinins. As conserved, exposed, and linear regions may be good vaccine targets, ... Thomas MN, Janzen GM, Markin A, Sharma A, Hewitt K. Active surveillance for influenza A virus in swine reveals within-farm reassortment and cocirculation of distinct subtypes and genetic clades. Vet Microbiol. 2025 Aug 11;309:110681. Abstract
submitted by kickingbird at Aug, 18, 2025 from Vet Microbiol. 2025 Aug 11;309:110681 (via https://www.sciencedirect.com/science/article/pii/S037811352)
Influenza A virus (IAV) is one of the most frequently detected respiratory pathogens in swine. A passive surveillance system in the United States (U.S.) provides aggregated metrics to quantify spatial ... Shanshan Guan, etc.,al. Optimization of the Monoclonal Antibody 3E1 through W32I Mutation Enhances Antiviral Efficacy against Influenza Virus Subtypes H1N1 and H3N2. Antiviral Research. Abstract
submitted by kickingbird at Aug, 17, 2025 from Antiviral Research (via https://www.sciencedirect.com/science/article/abs/pii/S01663)
The influenza virus has caused a global pandemic with significant morbidity and mortality, underscoring the need to optimize antibodies for improved antiviral efficacy. The monoclonal antibody 3E1 effectively ... Lorin Adams, etc.,al. Improved Resolution of Influenza Vaccination Responses With High-Throughput Live Virus Microneutralisation. Influenza and Other Respiratory Viruses. Abstract
submitted by kickingbird at Aug, 16, 2025 from Influenza and Other Respiratory Viruses (via https://onlinelibrary.wiley.com/doi/10.1111/irv.70140)
BackgroundInfluenza remains a significant threat to human and animal health. Assessing serological protection against influenza has relied upon haemagglutinin inhibition (HAI) assays, which are used to ... Hu, S., & Cui, J.. Cattle H5N1 Outbreak in US Driven by Cow’s ´Cross-Nursing´ Behavior: Elucidating a Novel Transmission Mechanism. Emerging Microbes & Infections. Abstract
submitted by kickingbird at Aug, 16, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
The emergence of highly pathogenic avian influenza A(H5N1) in US dairy cattle represents an unprecedented zoonotic event with critical pandemic implications. As of June 2025, over 1,070 dairy farms across ... Eduard Puente-Massaguer, etc.,al. [preprint]A clade 2.3.4.4b H5N1 virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoprotein. https://doi.org/10.1101/2025.08.14.670375. Abstract
submitted by kickingbird at Aug, 16, 2025 from https://doi.org/10.1101/2025.08.14.670375 (via https://www.biorxiv.org/content/10.1101/2025.08.14.670375v1)
The continuous evolution and widespread dissemination of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose critical challenges to global pandemic preparedness. In ... 6469 items, 20/Page, Page[15/324][|<<] [|<] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [>|] [>>|] |
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