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2026-6-11 21:53:08
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McKellar J, Rebendenne A, Wencker M, Moncorgé O, G. Mammalian and Avian Host Cell Influenza A Restriction Factors. Viruses. 2021 Mar 22;13(3):522.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 22;13(3):522 (via https://www.mdpi.com/1999-4915/13/3/522)
The threat of a new influenza pandemic is real. With past pandemics claiming millions of lives, finding new ways to combat this virus is essential. Host cells have developed a multi-modular system to detect ...

Michalak P, Piasecka J, Szutkowska B, Kierzek R, B. Conserved Structural Motifs of Two Distant IAV Subtypes in Genomic Segment 5 RNA. Viruses. 2021 Mar 22;13(3):525.  Abstract  
submitted by kickingbird at Apr, 4, 2021 from Viruses. 2021 Mar 22;13(3):525 (via https://www.mdpi.com/1999-4915/13/3/525)
The functionality of RNA is fully dependent on its structure. For the influenza A virus (IAV), there are confirmed structural motifs mediating processes which are important for the viral replication cycle, ...

Mengual-Chuliá B, Alonso-Cordero A, Cano L, Del Ma. Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain. Antimicrob Agents Chemother. 2021 Mar 29:AAC.02718.  Abstract  
submitted by kickingbird at Mar, 31, 2021 from Antimicrob Agents Chemother. 2021 Mar 29:AAC.02718 (via https://aac.asm.org/content/early/2021/03/23/AAC.02718-20)
Molecular surveillance by whole genome sequencing was used to monitor the susceptibility of circulating Influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions ...

Marriott AC, Gooch KE, Brown PJ, Ryan KA, Jones NJ. Severity of heterosubtypic influenza virus infection in ferrets is reduced by live attenuated influenza vaccine. NPJ Vaccines. 2021 Mar 29;6(1):43..  Abstract  
submitted by kickingbird at Mar, 31, 2021 from NPJ Vaccines. 2021 Mar 29;6(1):43. (via https://www.nature.com/articles/s41541-021-00306-7)
Live attenuated influenza vaccine (LAIV) is widely used to protect humans from seasonal influenza infection, particularly in children. In contrast to inactivated vaccines, the LAIV can induce both mucosal ...

Tang YS, Xu S, Chen YW, Wang JH, Shaw PC. Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction. Nucleic Acids Res. 2021 Mar 30:gkab203.  Abstract  
submitted by kickingbird at Mar, 31, 2021 from Nucleic Acids Res. 2021 Mar 30:gkab203 (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
The nucleoprotein (NP) of influenza virus is the core component of the ribonucleoprotein (RNP) and performs multiple structural and functional roles. Structures of the influenza A, B and D NP molecules ...

Xie XT, Yitbarek A, Astill J, Singh S, Khan SU, Sh. Within-host model of respiratory virus shedding and antibody response to H9N2 avian influenza virus vaccination and infection in chickens. Infect Dis Model. 2021 Mar 4;6:490-502.  Abstract  
submitted by kickingbird at Mar, 30, 2021 from Infect Dis Model. 2021 Mar 4;6:490-502 (via https://www.sciencedirect.com/science/article/pii/S246804272)
Avian influenza virus (AIV) H9N2 subtype is an infectious pathogen that can affect both the respiratory and gastrointestinal systems in chickens and continues to have an important economic impact on the ...

Heo GB, Kye SJ, Sagong M, Lee EK, Lee KN, Lee YN,. Genetic characterization of H9N2 avian influenza virus previously unrecognized in Korea. J Vet Sci. 2021 Mar;22(2):e21.  Abstract  
submitted by kickingbird at Mar, 29, 2021 from J Vet Sci. 2021 Mar;22(2):e21 (via https://vetsci.org/DOIx.php?id=10.4142/jvs.2021.22.e21)
In this study, we describe the isolation and characterization of previously unreported Y280-lineage H9N2 viruses from two live bird markets in Korea in June 2020. Genetic analysis revealed that they were ...

Wang X, Lin X, Zheng Z, Lu B, Wang J, Tan AH, Zhao. Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection. Nat Commun. 2021 Mar 26;12(1):1914.  Abstract  
submitted by kickingbird at Mar, 28, 2021 from Nat Commun. 2021 Mar 26;12(1):1914 (via https://www.nature.com/articles/s41467-021-22242-9)
Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate ...

Wu M, Su R, Gu Y, Yu Y, Li S, Sun H, Pan L, Cui X,. Molecular Characteristics, Antigenicity, Pathogenicity, and Zoonotic Potential of a H3N2 Canine Influenza Virus Currently Circulating in South China. Front Microbiol. 2021 Mar 9;12:628979..  Abstract  
submitted by kickingbird at Mar, 28, 2021 from Front Microbiol. 2021 Mar 9;12:628979. (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.6289)
Canine influenza viruses (CIVs) could be a source of influenza viruses which infect humans because canine are important companion pets. To assess the potential risk of H3N2 CIVs currently circulating in ...

Krischuns T, Lukarska M, Naffakh N, Cusack S. Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus. Annu Rev Biochem. 2021 Mar 26.  Abstract  
submitted by kickingbird at Mar, 28, 2021 from Annu Rev Biochem. 2021 Mar 26 (via https://www.annualreviews.org/doi/10.1146/annurev-biochem-07)
Influenza virus RNA-dependent RNA polymerase (FluPol) transcribes the viral RNA genome in the infected cell nucleus. In the 1970s, researchers showed that viral transcription depends on host RNA polymerase ...

Slaine PD, Kleer M, Duguay BA, Pringle ES, Kadijk. Thiopurines activate an antiviral unfolded protein response that blocks influenza A virus glycoprotein accumulation. J Virol. 2021 Mar 24:JVI.00453-21.  Abstract  
submitted by kickingbird at Mar, 26, 2021 from J Virol. 2021 Mar 24:JVI.00453-21 (via https://jvi.asm.org/content/early/2021/03/18/JVI.00453-21)
Influenza A viruses (IAVs) utilize host shutoff mechanisms to limit antiviral gene expression and redirect translation machinery to the synthesis of viral proteins. Previously, we showed that IAV replication ...

Chen L, Zhu L, Chen J. Human Interferon Inducible Transmembrane Protein 3 (IFITM3) Inhibits Influenza Virus A Replication and Inflammation by Interacting with ABHD16A. Biomed Res Int. 2021 Mar 3;2021:6652147.  Abstract  
submitted by kickingbird at Mar, 26, 2021 from Biomed Res Int. 2021 Mar 3;2021:6652147 (via https://www.hindawi.com/journals/bmri/2021/6652147/)
Studies have shown that human interferon inducible transmembrane protein (hIFITMs) family proteins have broad-spectrum antiviral capabilities. Preliminary studies in our laboratory have tentatively proved ...

Fusade-Boyer M, Djegui F, Batawui K, Byuragaba DK,. Antigenic and Molecular Characterization of Low Pathogenic Avian Influenza A(H9N2) Viruses in Sub-Saharan Africa from 2017 through 2019. Emerg Microbes Infect. 2021 Mar 23:1-32.  Abstract  
submitted by kickingbird at Mar, 24, 2021 from Emerg Microbes Infect. 2021 Mar 23:1-32 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years. However, in 2017, low pathogenic avian influenza ...

Jeong S, Otgontogtokh N, Lee DH, Davganyam B, Lee. Highly Pathogenic Avian Influenza Clade 2.3.4.4 Subtype H5N6 Viruses Isolated from Wild Whooper Swans, Mongolia, 2020. Emerg Infect Dis. 2021 Apr;27(4):1181-1183.  Abstract  
submitted by kickingbird at Mar, 24, 2021 from Emerg Infect Dis. 2021 Apr;27(4):1181-1183 (via https://wwwnc.cdc.gov/eid/article/27/4/20-3859_article)
We identified clade 2.3.4.4 highly pathogenic avian influenza A(H5N6) viruses from whooper swans (Cygnus cygnus) found dead in Mongolia. The identification of these infections in wild birds in this area ...

Wang J, Jin X, Hu J, Wu Y, Zhang M, Li X, Chen J,. Genetic Evolution Characteristics of Genotype G57 Virus, A Dominant Genotype of H9N2 Avian Influenza Virus. Front Microbiol. 2021 Mar 3;12:633835.  Abstract  
submitted by kickingbird at Mar, 23, 2021 from Front Microbiol. 2021 Mar 3;12:633835 (via https://www.frontiersin.org/articles/10.3389/fmicb.2021.6338)
This study aimed to investigate the genetic evolution of the H9N2 avian influenza virus (AIV). Whole genome phylogenetic trees were constructed based on 306 H9N2 avian influenza strains collected in China ...

Ding F, Li Y, Huang B, Edwards J, Cai C, Zhang G,. Infection and risk factors of human and avian influenza in pigs in south China. Prev Vet Med. 2021 Mar 5;190:105317.  Abstract  
submitted by kickingbird at Mar, 22, 2021 from Prev Vet Med. 2021 Mar 5;190:105317 (via https://www.sciencedirect.com/science/article/abs/pii/S01675)
The coinfection of swine influenza (SI) strains and avian/human-source influenza strains in piggeries can contribute to the evolution of new influenza viruses with pandemic potential. This study analyzed ...

Zhu J, Jiang Z, Liu J. The matrix gene of pdm/09 H1N1 contributes to the pathogenicity and transmissibility of SIV in mammals. Vet Microbiol. 2021 Mar 12;255:109039.  Abstract  
submitted by kickingbird at Mar, 21, 2021 from Vet Microbiol. 2021 Mar 12;255:109039 (via https://www.sciencedirect.com/science/article/pii/S037811352)
The H1N1 influenza virus of swine-origin was responsible for the H1N1 pandemic in 2009 (pdm/09 H1N1), where the virus was transmitted to humans and then spread between people, and its continued circulation ...

Saeed NM, Rashid PMA, Dyary HO. Genetic characterization of highly pathogenic avian influenza A (H5N8) virus isolated from domestic geese in Iraq, 2018. BMC Vet Res. 2021 Mar 19;17(1):124.  Abstract  
submitted by kickingbird at Mar, 21, 2021 from BMC Vet Res. 2021 Mar 19;17(1):124 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Background: Influenza viruses are a continuous threat to avian and mammalian species, causing epidemics and pandemics. After the circulation of H5N1 in 2006, 2015, and 2016 in Iraq, an H5N8 influenza virus ...

Oshansky CM, King J, Lu D, Zhou J, Pavetto C, Horw. Adjuvanted recombinant hemagglutinin H7 vaccine to highly pathogenic influenza A(H7N9) elicits high and sustained antibody responses in healthy adults. NPJ Vaccines. 2021 Mar 19;6(1):41.  Abstract  
submitted by kickingbird at Mar, 21, 2021 from NPJ Vaccines. 2021 Mar 19;6(1):41 (via https://www.nature.com/articles/s41541-021-00287-7)
An unprecedented number of human infections with avian influenza A(H7N9) in the fifth epidemic wave during the winter of 2016-2017 in China and their antigenic divergence from the viruses that emerged ...

Zinyakov NG, Sosipatorova VY, Andriyasov AV, Ovchi. Genetic analysis of genotype G57 H9N2 avian influenza virus isolate A/chicken/Tajikistan/2379/2018 recovered in Central Asia. Arch Virol. 2021 Mar 19.  Abstract  
submitted by kickingbird at Mar, 20, 2021 from Arch Virol. 2021 Mar 19 (via https://link.springer.com/article/10.1007/s00705-021-05011-3)
This paper presents genetic data on the full genome analysis of A/chicken/Tajikistan/2379/2018 H9N2 influenza virus isolated in September 2018 from chicken pathological material received from poultry farms ...

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