Rozek W, Kwasnik M, Socha W, Sztromwasser P, Rola. Analysis of Single Nucleotide Variants (SNVs) Induced by Passages of Equine Influenza Virus H3N8 in Embryonated Chicken Eggs. Viruses. 2021 Aug 5;13(8):1551. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 5;13(8):1551 (via https://www.mdpi.com/1999-4915/13/8/1551)
Vaccination is an effective method for the prevention of influenza virus infection. Many manufacturers use embryonated chicken eggs (ECE) for the propagation of vaccine strains. However, the adaptation ... Oladunni FS, Oseni SO, Martinez-Sobrido L, Chamber. Equine Influenza Virus and Vaccines. Viruses. 2021 Aug 20;13(8):1657. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Aug 20;13(8):1657 (via https://www.mdpi.com/1999-4915/13/8/1657)
Equine influenza virus (EIV) is a constantly evolving viral pathogen that is responsible for yearly outbreaks of respiratory disease in horses termed equine influenza (EI). There is currently no evidence ... Frymus T, Belák S, Egberink H, Hofmann-Lehmann R,. Influenza Virus Infections in Cats. Viruses. 2021 Jul 23;13(8):1435. Abstract
submitted by kickingbird at Aug, 29, 2021 from Viruses. 2021 Jul 23;13(8):1435 (via https://www.mdpi.com/1999-4915/13/8/1435)
In the past, cats were considered resistant to influenza. Today, we know that they are susceptible to some influenza A viruses (IAVs) originating in other species. Usually, the outcome is only subclinical ... Stadtmueller MN, Bhatia S, Kiran P, Hilsch M, Reit. Evaluation of Multivalent Sialylated Polyglycerols for Resistance Induction in and Broad Antiviral Activity against Influenza A Viruses. J Med Chem. 2021 Aug 25. Abstract
submitted by kickingbird at Aug, 26, 2021 from J Med Chem. 2021 Aug 25 (via https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00794)
The development of multivalent sialic acid-based inhibitors active against a variety of influenza A virus (IAV) strains has been hampered by high genetic and structural variability of the targeted viral ... Wilks LR, Joshi G, Grisham MR, Gill HS. Tyrosine-Based Cross-Linking of Peptide Antigens to Generate Nanoclusters with Enhanced Immunogenicity: Demonstration Using the Conserved M2e Peptide of Influenza A. ACS Infect Dis. 2021 Aug 25. Abstract
submitted by kickingbird at Aug, 26, 2021 from ACS Infect Dis. 2021 Aug 25 (via https://pubs.acs.org/doi/10.1021/acsinfecdis.1c00219)
A method of creating nanoclusters (NCs) from soluble peptide molecules is described utilizing an approach based on a tyrosine-tyrosine cross-linking reaction. A reactive tag comprising histidine and tyrosine ... Zhang J, Ma K, Li B, Chen Y, Qiu Z, Xing J, Huang. A risk marker of tribasic hemagglutinin cleavage site in influenza A (H9N2) virus. Commun Biol. 2021 Jan 15;4(1):71. Abstract
submitted by kickingbird at Aug, 25, 2021 from Commun Biol. 2021 Jan 15;4(1):71 (via https://www.nature.com/articles/s42003-020-01589-7)
Low pathogenic avian influenza A(H9N2) virus is endemic worldwide and continually recruit internal genes to generate human-infecting H5N1, H5N6, H7N9, and H10N8 influenza variants. Here we show that hemagglutinin ... Li X, Gu M, Wang X, Gao R, Bu X, Hao X, Ma J, Hu J. G1-like M and PB2 genes are preferentially incorporated into H7N9 progeny virions during genetic reassortment. BMC Vet Res. 2021 Feb 15;17(1):80. Abstract
submitted by kickingbird at Aug, 25, 2021 from BMC Vet Res. 2021 Feb 15;17(1):80 (via https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-)
Background: Genotype S H9N2 viruses have become predominant in poultry in China since 2010. These viruses frequently donate their whole internal gene segments to other emerging influenza A subtypes such ... Blaurock C, Blohm U, Luttermann C, Holzerland J, S. The C-Terminus of Non-Structural Protein 1 (NS1) in H5N8 Clade 2.3.4.4 Avian Influenza Virus Affects Virus Fitness in Human Cells and Virulence in Mice. Emerg Microbes Infect. 2021 Aug 22:1-48.. Abstract
submitted by kickingbird at Aug, 24, 2021 from Emerg Microbes Infect. 2021 Aug 22:1-48. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown. The non-structural protein 1 (NS1) ... Han T, Lai Y, Jiang Y, Liu X, Li D. Influenza A virus infects pulmonary microvascular endothelial cells leading to microvascular leakage and release of pro-inflammatory cytokines. PeerJ. 2021 Aug 3;9:e11892. Abstract
submitted by kickingbird at Aug, 22, 2021 from PeerJ. 2021 Aug 3;9:e11892 (via https://peerj.com/articles/11892/)
Objective: To investigate the replication of influenza A virus A/Puerto Rico/8/34 (H1N1) in pulmonary microvascular endothelial cells and its effect on endothelial barrier function.Methods: Human pulmonary ... Flores-Torres AS, Rendon A, Salinas-Carmona MC, Sa. Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09. Viral Immunol. 2021 Aug 19. Abstract
submitted by kickingbird at Aug, 22, 2021 from Viral Immunol. 2021 Aug 19 (via https://www.liebertpub.com/doi/10.1089/vim.2021.0004)
Eosinophils participate in the immune response against many pathogens, including viruses. Since mouse eosinophils are susceptible to influenza A virus infection and possess antiviral activity, we evaluated ... Chen Y, Graf L, Chen T, Liao Q, Bai T, Petric PP,. Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus. Science. 2021 Aug 20;373(6557):918-922. Abstract
submitted by kickingbird at Aug, 20, 2021 from Science. 2021 Aug 20;373(6557):918-922 (via https://science.sciencemag.org/content/373/6557/918)
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing ... Zhong ZJ, Hu XT, Cheng LP, Zhang XY, Zhang Q, Zhan. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors. Eur J Med Chem. 2021 Aug 13;225:113762. Abstract
submitted by kickingbird at Aug, 20, 2021 from Eur J Med Chem. 2021 Aug 13;225:113762 (via https://www.sciencedirect.com/science/article/abs/pii/S02235)
Neuraminidase (NA) is an important target for the treatment of influenza. In this study, a new lead NA inhibitor, 4 (ZINC01121127), was discovered by pharmacophore-based virtual screening and molecular ... Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545. Abstract
submitted by kickingbird at Aug, 20, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/pii/S016817022)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ... Mutisari D, Muflihanah M, Wibawa H, Hendrawati F,. Phylogenetic analysis of HPAI H5N1 virus from duck swab specimens in Indonesia. J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354.. Abstract
submitted by kickingbird at Aug, 17, 2021 from J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354. (via https://www.ejmanager.com/mnstemps/39/39-1617077743.pdf?t=16)
Objective: A phylogenetic study was carried out on the avian influenza virus (AIV) isolated from a disease outbreak in Sidenreng Rappang Regency, South Sulawesi, Indonesia, in 2018.Material and methods: ... Wang Z, Chen Y, Chen H, Meng F, Tao S, Ma S, Qiao. A single amino acid at position 158 in hemagglutinin affects the antigenic property of Eurasian Avian-like H1N1 Swine influenza viruses. Transbound Emerg Dis. 2021 Aug 15. Abstract
submitted by kickingbird at Aug, 17, 2021 from Transbound Emerg Dis. 2021 Aug 15 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14288)
Influenza viruses have been posing a great threat to public health and animal industry. The developed vaccines have been widely used to reduce the risk of potential pandemic; however, the ongoing antigenic ... Faleye TOC, Adams D, Adhikari S, Sandrolini H, Hal. Use of hemagglutinin and neuraminidase amplicon-based high-throughput sequencing with variant analysis to detect co-infection and resolve identical consensus sequences of seasonal influenza in a unive. BMC Infect Dis. 2021 Aug 13;21(1):810. Abstract
submitted by kickingbird at Aug, 16, 2021 from BMC Infect Dis. 2021 Aug 13;21(1):810 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
Background: Local transmission of seasonal influenza viruses (IVs) can be difficult to resolve. Here, we study if coupling high-throughput sequencing (HTS) of hemagglutinin (HA) and neuraminidase (NA) ... Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545. Abstract
submitted by kickingbird at Aug, 16, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ... Tang J, Gao R, Liu L, Zhang S, Liu J, Li X, Fang Q. Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice. Sci Rep. 2021 Aug 11;11(1):16293. Abstract
submitted by kickingbird at Aug, 13, 2021 from Sci Rep. 2021 Aug 11;11(1):16293 (via https://www.nature.com/articles/s41598-021-95771-4)
That the high frequency and good replication capacity of strains with reduced susceptibility to neuraminidase inhibitors (NAIs) in highly pathogenic avian influenza H7N9 (HPAI H7N9) virus made it a significance ... Xu X, Zhang L, Chu JTS, Wang Y, Chin AWH, Chong TH. A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2021 Aug 11:gkab660.. Abstract
submitted by kickingbird at Aug, 12, 2021 from Nucleic Acids Res. 2021 Aug 11:gkab660. (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
During RNA elongation, the influenza A viral (IAV) RNA-dependent RNA polymerase (RdRp) residues in the active site interact with the triphosphate moiety of nucleoside triphosphate (NTP) for catalysis. ... Kaplan BS, Anderson TK, Chang J, Santos J, Perez D. Evolution and antigenic advancement of N2 neuraminidase of swine influenza A viruses circulating in the United States following two separate introductions from human seasonal viruses. J Virol. 2021 Aug 11:JVI0063221. Abstract
submitted by kickingbird at Aug, 12, 2021 from J Virol. 2021 Aug 11:JVI0063221 (via https://journals.asm.org/doi/10.1128/JVI.00632-21)
Two separate introductions of human seasonal N2 neuraminidase genes were sustained in United States swine since 1998 (N2-98) and 2002 (N2-02). Herein, we characterized the antigenic evolution of the N2 ... 6896 items, 20/Page, Page[138/345][|<<] [|<] [131] [132] [133] [134] [135] [136] [137] [138] [139] [140] [>|] [>>|] |
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