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Thulin NK, Wang TT. The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses. Vaccines (Basel). 2018 Jun 29;6(3).  Abstract  
submitted by kickingbird at Jul, 9, 2018 from Vaccines (Basel). 2018 Jun 29;6(3) (via https://www.ncbi.nlm.nih.gov/pubmed/29966222)
Recent studies have revealed multiple roles for Fc gamma receptors (FcγRs) in broad immunity against influenza viruses. Activating FcγR pathways can be harnessed to confer protection mediated ...

Qiang X, Kou Z, Fang G, Wang Y. Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses. Molecules. 2018 Jun 29;23(7).  Abstract  
submitted by kickingbird at Jul, 9, 2018 from Molecules. 2018 Jun 29;23(7) (via https://www.ncbi.nlm.nih.gov/pubmed/29966263)
Avian influenza virus (AIV) can directly cross species barriers and infect humans with high fatality. Using machine learning methods, the present paper scores the amino acid mutations and predicts interspecies ...

Zhu R, etc.,al. Genetic and biological characterization of H9N2 avian influenza viruses isolated in China from 2011 to 2014.. PLoS One. 2018 Jul 3;13(7):e0199260..  Abstract  
submitted by kickingbird at Jul, 9, 2018 from PLoS One. 2018 Jul 3;13(7):e0199260. (via https://www.ncbi.nlm.nih.gov/pubmed/29969454)
The genotypes of the H9N2 avian influenza viruses have changed since 2013 when almost all H9N2 viruses circulating in chickens in China were genotype 57 (G57) with the fittest lineage of each gene. To ...

Smith BL, etc.,al. Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools. MBio. 2018 Jul 3;9(4)..  Abstract  
submitted by kickingbird at Jul, 9, 2018 from MBio. 2018 Jul 3;9(4). (via https://www.ncbi.nlm.nih.gov/pubmed/29970470)
Influenza A viruses cause an annual contagious respiratory disease in humans and are responsible for periodic high-mortality human pandemics. Pandemic influenza A viruses usually result from the reassortment ...

Obul M, etc.,al. Structural modification on rupestonic acid leads to highly potent inhibitors against influenza virus. Mol Divers. 2018 Jul 3..  Abstract  
submitted by kickingbird at Jul, 9, 2018 from Mol Divers. 2018 Jul 3. (via https://www.ncbi.nlm.nih.gov/pubmed/29971616)
Influenza viruses are responsible for seasonal epidemics and occasional pandemics, which cause significant morbidity and mortality. Although several drugs (adamantanes and neuraminidase inhibitors) are ...

García-Pérez CA, etc.,al. Proteome-wide analysis of human motif-domain interactions mapped on influenza a virus. BMC Bioinformatics. 2018 Jun 25.  Abstract  
submitted by kickingbird at Jul, 3, 2018 from BMC Bioinformatics. 2018 Jun 25 (via https://www.ncbi.nlm.nih.gov/pubmed/29940841)
BACKGROUND: The influenza A virus (IAV) is a constant threat for humans worldwide. The understanding of motif-domain protein participation is essential to combat the pathogen.RESULTS: In this study, a ...

Makarkov AI, Patel AR, Bainov V, Ward BJ, et al. A novel serological assay for influenza based on DiD fluorescence dequenching that is free from observer bias and potentially automatable - A proof of concept study. Vaccine 2018;36:4485-4493.  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Vaccine 2018;36:4485-4493 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29929824/)
BACKGROUND: Serum hemagglutination inhibition (HAI) and microneutralization (MN) antibodies are often used as a correlate of protection for influenza. However, these manual assays are labor-intensive and ...

Ping X, Hu W, Xiong R, Zhang X, et a. Generation of a broadly reactive influenza H1 antigen using a consensus HA sequence. Vaccine 2018 Jun 27..  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Vaccine 2018 Jun 27. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29960799/)
H1N1, one of the most prevalent influenza A virus subtypes affecting the human population, can cause infections varying from mild respiratory syndrome to severe pneumonia. The current H1N1 vaccine needs ...

Liu F, Tzeng WP, Horner L, Kamal RP, et al.. Both Immune Priming and Egg-adaptation in the Vaccine Influence Antibody Responses to Circulating A(H1N1)pdm09 Viruses Following Influenza Vaccination in Adults. Infect Dis 2018 Jun 21.  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Infect Dis 2018 Jun 21 (via https://www.ncbi.nlm.nih.gov/m/pubmed/29931203/)
Background: Although ferret antisera used in influenza surveillance did not detect antigenic drift of A(H1N1)pdm09 viruses during 2015-16 season, low vaccine effectiveness was reported in adults. We investigated ...

Root JJ, Bosco-Lauth AM, Marlenee NL, Bowen RA, et. Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. Arch Virol 2018 Jun 13..  Abstract  
submitted by kickingbird at Jul, 3, 2018 from Arch Virol 2018 Jun 13. (via https://www.ncbi.nlm.nih.gov/m/pubmed/29948379/)
During 2014-2015, clade 2.3.4.4 H5Nx highly pathogenic (HP) avian influenza A viruses (IAV) were first detected in North America and subsequently caused one of the largest agricultural emergencies in U.S.HISTORY: ...

Prabhu SS, Chakraborty TT, Kumar N, Banerjee I. Association between IFITM3 rs12252 polymorphism and influenza susceptibility and severity: A meta-analysis. Gene. 2018 Jun 22.  Abstract  
submitted by kickingbird at Jun, 28, 2018 from Gene. 2018 Jun 22 (via https://www.ncbi.nlm.nih.gov/pubmed/29940276)
Intrinsic host susceptibility to viral infections plays a major role in determining infection severity in different individuals. In human influenza virus infections, multiple genetic association studies ...

Rim A, Nacira L, Abdeljelil G.. Viral interference between Low Pathogenic Avian Influenza H9N2 and avian infectious bronchitis viruses in vitro and in ovo. J Virol Methods. 2018 Jun 22.  Abstract  
submitted by kickingbird at Jun, 28, 2018 from J Virol Methods. 2018 Jun 22 (via https://www.ncbi.nlm.nih.gov/pubmed/29940196)
BACKGROUND: Low pathogenic avian influenza (LPAI) H9N2 and infectious bronchitis virus (IBV) are important pathogens of poultry, causing important economic losses for the sector. Replication interference ...

Hong SC, etc.,al. Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe. Angew Chem Int Ed Engl. 2018 Jun 22.  Abstract  
submitted by kickingbird at Jun, 28, 2018 from Angew Chem Int Ed Engl. 2018 Jun 22 (via https://www.ncbi.nlm.nih.gov/pubmed/29933516)
Avian Influenza (AI) caused an annual epidemic outbreak that led to destroying tens of millions of poultry worldwide. Current gold standard AI diagnosis method is an embryonic egg-based hemagglutination ...

Xuyong Li, etc.,al. High frequency of reassortment after co-infection of chickens with the H4N6 and H9N2 influenza A viruses and the biological characteristics of the reassortants. Vet Micro Volume 222, August 2018, Pages 11–17.  Abstract  
submitted by kickingbird at Jun, 27, 2018 from Vet Micro Volume 222, August 2018, Pages 11–17 (via https://www.sciencedirect.com/science/article/pii/S037811351)
H4 and H9 avian influenza viruses (AIVs) are two of the most prevalent influenza viruses worldwide. The co-existence of H4 and H9 viruses in multiple avian species provides an opportunity for the generation ...

Hiroshi Ueki, etc.,al. In vivo imaging of the pathophysiological changes and neutrophil dynamics in influenza virus-infected mouse lungs. PNAS June 25, 2018. 201806265;.  Abstract  
submitted by kickingbird at Jun, 27, 2018 from PNAS June 25, 2018. 201806265; (via http://www.pnas.org/content/early/2018/06/21/1806265115)
The pathophysiological changes that occur in lungs infected with influenza viruses are poorly understood. Here we established an in vivo imaging system that combines two-photon excitation microscopy and ...

WALZ L, Kays SK, Zimmer G, von Messling V, et al. Sialidase-Inhibiting Antibody Titers Correlate with Protection from Heterologous Influenza Virus Strains of the Same Neuraminidase Subtype. J Virol. 2018 Jun 20. pii: JVI.01006-18.  Abstract  
submitted by kickingbird at Jun, 24, 2018 from J Virol. 2018 Jun 20. pii: JVI.01006-18 (via https://www.ncbi.nlm.nih.gov/pubmed/29925654)
Immune responses induced by currently licensed inactivated influenza vaccines are mainly directed against the hemagglutinin (HA) glycoprotein, the immunodominant antigen of influenza viruses. The resulting ...

LIN Q, Li T, Chen Y, Lau SY, et al. Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J Virol. 2018 Jun 20.  Abstract  
submitted by kickingbird at Jun, 24, 2018 from J Virol. 2018 Jun 20 (via https://www.ncbi.nlm.nih.gov/pubmed/29925655)
Human infection with highly pathogenic avian influenza A viruses lead to cause severe diseases and fatalities. We previously identified a potent and broad-neutralizing antibody (bnAb), 13D4, against the ...

DE VRIES RD, Altenburg AF, Nieuwkoop NJ, de Brui. Induction of Cross-Clade Antibody and T-Cell Responses by an MVA-Based Influenza H5N1 Vaccine in a Randomized Phase I/IIa Clinical Trial. J Infect Dis. 2018 Apr 18.  Abstract  
submitted by kickingbird at Jun, 24, 2018 from J Infect Dis. 2018 Apr 18 (via https://www.ncbi.nlm.nih.gov/pubmed/29912453)
Background: Highly pathogenic avian influenza viruses continue to circulate in poultry and wild birds and occasionally infect humans, sometimes with fatal outcome. Development of vaccines is a priority ...

LA FRAZIA S, Piacentini S, Riccio A, Rossignol J. The second-generation thiazolide haloxanide is a potent inhibitor of avian influenza virus replication. Antiviral Res. 2018 Jun 13.  Abstract  
submitted by kickingbird at Jun, 24, 2018 from Antiviral Res. 2018 Jun 13 (via https://www.ncbi.nlm.nih.gov/pubmed/29908209)
The emergence of new avian influenza virus (AIV) strains able to infect humans represents a serious threat to global human health. In addition to surveillance and vaccine development, antiviral therapy ...

?wi?toń E, ?mietanka K.. Phylogenetic and molecular analysis of highly pathogenic avian influenza H5N8 and H5N5 viruses detected in Poland in 2016-2017. Transbound Emerg Dis. 2018 Jun 19.  Abstract  
submitted by kickingbird at Jun, 24, 2018 from Transbound Emerg Dis. 2018 Jun 19 (via https://www.ncbi.nlm.nih.gov/pubmed/29920971)
Sixty-five poultry outbreaks and sixty-eight events in wild birds were reported during the highly pathogenic H5N8/H5N5 avian influenza epidemic in Poland in 2016-2017. The analysis of all gene segment ...

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