Blaurock C, Blohm U, Luttermann C, Holzerland J, S. The C-Terminus of Non-Structural Protein 1 (NS1) in H5N8 Clade 2.3.4.4 Avian Influenza Virus Affects Virus Fitness in Human Cells and Virulence in Mice. Emerg Microbes Infect. 2021 Aug 22:1-48.. Abstract
submitted by kickingbird at Aug, 24, 2021 from Emerg Microbes Infect. 2021 Aug 22:1-48. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2021.1)
Avian influenza viruses (AIV) H5N8 clade 2.3.4.4 pose a public health threat but the viral factors relevant for its potential adaptation to mammals are largely unknown. The non-structural protein 1 (NS1) ... Han T, Lai Y, Jiang Y, Liu X, Li D. Influenza A virus infects pulmonary microvascular endothelial cells leading to microvascular leakage and release of pro-inflammatory cytokines. PeerJ. 2021 Aug 3;9:e11892. Abstract
submitted by kickingbird at Aug, 22, 2021 from PeerJ. 2021 Aug 3;9:e11892 (via https://peerj.com/articles/11892/)
Objective: To investigate the replication of influenza A virus A/Puerto Rico/8/34 (H1N1) in pulmonary microvascular endothelial cells and its effect on endothelial barrier function.Methods: Human pulmonary ... Flores-Torres AS, Rendon A, Salinas-Carmona MC, Sa. Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09. Viral Immunol. 2021 Aug 19. Abstract
submitted by kickingbird at Aug, 22, 2021 from Viral Immunol. 2021 Aug 19 (via https://www.liebertpub.com/doi/10.1089/vim.2021.0004)
Eosinophils participate in the immune response against many pathogens, including viruses. Since mouse eosinophils are susceptible to influenza A virus infection and possess antiviral activity, we evaluated ... Chen Y, Graf L, Chen T, Liao Q, Bai T, Petric PP,. Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus. Science. 2021 Aug 20;373(6557):918-922. Abstract
submitted by kickingbird at Aug, 20, 2021 from Science. 2021 Aug 20;373(6557):918-922 (via https://science.sciencemag.org/content/373/6557/918)
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing ... Zhong ZJ, Hu XT, Cheng LP, Zhang XY, Zhang Q, Zhan. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors. Eur J Med Chem. 2021 Aug 13;225:113762. Abstract
submitted by kickingbird at Aug, 20, 2021 from Eur J Med Chem. 2021 Aug 13;225:113762 (via https://www.sciencedirect.com/science/article/abs/pii/S02235)
Neuraminidase (NA) is an important target for the treatment of influenza. In this study, a new lead NA inhibitor, 4 (ZINC01121127), was discovered by pharmacophore-based virtual screening and molecular ... Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545. Abstract
submitted by kickingbird at Aug, 20, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/pii/S016817022)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ... Mutisari D, Muflihanah M, Wibawa H, Hendrawati F,. Phylogenetic analysis of HPAI H5N1 virus from duck swab specimens in Indonesia. J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354.. Abstract
submitted by kickingbird at Aug, 17, 2021 from J Adv Vet Anim Res. 2021 Jun 28;8(2):346-354. (via https://www.ejmanager.com/mnstemps/39/39-1617077743.pdf?t=16)
Objective: A phylogenetic study was carried out on the avian influenza virus (AIV) isolated from a disease outbreak in Sidenreng Rappang Regency, South Sulawesi, Indonesia, in 2018.Material and methods: ... Wang Z, Chen Y, Chen H, Meng F, Tao S, Ma S, Qiao. A single amino acid at position 158 in hemagglutinin affects the antigenic property of Eurasian Avian-like H1N1 Swine influenza viruses. Transbound Emerg Dis. 2021 Aug 15. Abstract
submitted by kickingbird at Aug, 17, 2021 from Transbound Emerg Dis. 2021 Aug 15 (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14288)
Influenza viruses have been posing a great threat to public health and animal industry. The developed vaccines have been widely used to reduce the risk of potential pandemic; however, the ongoing antigenic ... Faleye TOC, Adams D, Adhikari S, Sandrolini H, Hal. Use of hemagglutinin and neuraminidase amplicon-based high-throughput sequencing with variant analysis to detect co-infection and resolve identical consensus sequences of seasonal influenza in a unive. BMC Infect Dis. 2021 Aug 13;21(1):810. Abstract
submitted by kickingbird at Aug, 16, 2021 from BMC Infect Dis. 2021 Aug 13;21(1):810 (via https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128)
Background: Local transmission of seasonal influenza viruses (IVs) can be difficult to resolve. Here, we study if coupling high-throughput sequencing (HTS) of hemagglutinin (HA) and neuraminidase (NA) ... Burnham AJ, Miller JR, Singh I, Billings EA, Rush. Novel isoforms of influenza virus PA-X and PB1-F2 indicated by automatic annotation. Virus Res. 2021 Aug 12:198545. Abstract
submitted by kickingbird at Aug, 16, 2021 from Virus Res. 2021 Aug 12:198545 (via https://www.sciencedirect.com/science/article/abs/pii/S01681)
The influenza A virus genome contains 8 gene segments encoding 10 commonly recognized proteins. Additional protein products have been identified including PB1-F2 and PA-X. We report in-silico identification ... Tang J, Gao R, Liu L, Zhang S, Liu J, Li X, Fang Q. Substitution of I222L-E119V in neuraminidase from highly pathogenic avian influenza H7N9 virus exhibited synergistic resistance effect to oseltamivir in mice. Sci Rep. 2021 Aug 11;11(1):16293. Abstract
submitted by kickingbird at Aug, 13, 2021 from Sci Rep. 2021 Aug 11;11(1):16293 (via https://www.nature.com/articles/s41598-021-95771-4)
That the high frequency and good replication capacity of strains with reduced susceptibility to neuraminidase inhibitors (NAIs) in highly pathogenic avian influenza H7N9 (HPAI H7N9) virus made it a significance ... Xu X, Zhang L, Chu JTS, Wang Y, Chin AWH, Chong TH. A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase. Nucleic Acids Res. 2021 Aug 11:gkab660.. Abstract
submitted by kickingbird at Aug, 12, 2021 from Nucleic Acids Res. 2021 Aug 11:gkab660. (via https://academic.oup.com/nar/advance-article/doi/10.1093/nar)
During RNA elongation, the influenza A viral (IAV) RNA-dependent RNA polymerase (RdRp) residues in the active site interact with the triphosphate moiety of nucleoside triphosphate (NTP) for catalysis. ... Kaplan BS, Anderson TK, Chang J, Santos J, Perez D. Evolution and antigenic advancement of N2 neuraminidase of swine influenza A viruses circulating in the United States following two separate introductions from human seasonal viruses. J Virol. 2021 Aug 11:JVI0063221. Abstract
submitted by kickingbird at Aug, 12, 2021 from J Virol. 2021 Aug 11:JVI0063221 (via https://journals.asm.org/doi/10.1128/JVI.00632-21)
Two separate introductions of human seasonal N2 neuraminidase genes were sustained in United States swine since 1998 (N2-98) and 2002 (N2-02). Herein, we characterized the antigenic evolution of the N2 ... Yang F, Xiao Y, Liu F, Cheng L, Yao H, Wu N, Wu H. Genetic analysis and biological characteristics of novel clade 2.3.4.4 reassortant H5N6 avian influenza viruses from poultry in Eastern China in 2016. Int J Infect Dis. 2021 Aug 5:S1201-9712(21)00632-9. Abstract
submitted by kickingbird at Aug, 9, 2021 from Int J Infect Dis. 2021 Aug 5:S1201-9712(21)00632-9 (via https://www.ijidonline.com/article/S1201-9712(21)00632-9/ful)
Objectives: The continuous evolution of highly pathogenic H5N6 avian influenza viruses (AIVs) causes outbreaks in wildfowls and poultry and occasional human infections. To better understand the genetic ... Del Rosario JMM, da Costa KAS, Asbach B, Ferrara F. Exploiting Pan Influenza A and Pan Influenza B Pseudotype Libraries for Efficient Vaccine Antigen Selection. Vaccines (Basel). 2021 Jul 5;9(7):741. Abstract
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 5;9(7):741 (via https://www.mdpi.com/2076-393X/9/7/741)
We developed an influenza hemagglutinin (HA) pseudotype library encompassing Influenza A subtypes HA1-18 and Influenza B subtypes (both lineages) to be employed in influenza pseudotype microneutralization ... Zhang S, Tang X, Wang S, Shi F, Duan C, Bi F, Suo. Establishment of Recombinant Eimeria acervulina Expressing Multi-Copies M2e Derived from Avian Influenza Virus H9N2. Vaccines (Basel). 2021 Jul 16;9(7):791. Abstract
submitted by kickingbird at Aug, 9, 2021 from Vaccines (Basel). 2021 Jul 16;9(7):791 (via https://www.mdpi.com/2076-393X/9/7/791)
The potential of Eimeria parasites as live vaccine vectors has been reported with successful genetic manipulation on several species like E. tenella, E. mitis and E. necatrix. Among seven Eimeria species ... Lee YN, Lee DH, Shin JI, Si YJ, Lee JH, Baek YG, H. Pathogenesis and genetic characteristics of a novel reassortant low pathogenic avian influenza A(H7N6) virus isolated in Cambodia in 2019. Transbound Emerg Dis. 2021 Aug 4.. Abstract
submitted by kickingbird at Aug, 5, 2021 from Transbound Emerg Dis. 2021 Aug 4. (via https://onlinelibrary.wiley.com/doi/10.1111/tbed.14256)
The first human case of zoonotic A(H7N4) avian influenza virus (AIV) infection was reported in early 2018 in China. Two months after this case, novel A(H7N4) viruses phylogenetically related to the Jiangsu ... Finch J, Zuckerman M, Smith M. Investigating the potential sequence variation in the influenza A matrix genes during the 2018-2019 season in samples from a local population in London. J Virol Methods. 2021 Jul 30:114250.. Abstract
submitted by kickingbird at Aug, 4, 2021 from J Virol Methods. 2021 Jul 30:114250. (via https://www.sciencedirect.com/science/article/abs/pii/S01660)
Recent publications have highlighted the emergence of mutations in the M1 gene of both influenza A H1N1pdm09 and H3N2 subtypes affecting the performance of commercial RT-PCR assays. Respiratory samples ... Han AX, Felix Garza ZC, Welkers MR, Vigeveno RM, T. Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children. Elife. 2021 Aug 3;10:e68917. Abstract
submitted by kickingbird at Aug, 4, 2021 from Elife. 2021 Aug 3;10:e68917 (via https://elifesciences.org/articles/68917)
The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because ... Spackman E, Pantin-Jackwood MJ, Sitaras I, Stephen. Identification of Efficacious Vaccines Against Contemporary North American H7 Avian Influenza Viruses. Avian Dis. 2021 Mar;65(1):113-121. Abstract
submitted by kickingbird at Aug, 3, 2021 from Avian Dis. 2021 Mar;65(1):113-121 (via https://bioone.org/journals/avian-diseases/volume-65/issue-1)
Five vaccines, including four inactivated, whole-virus water-in-oil adjuvanted vaccines and a commercial nonreplicating alphavirus-vectored RNA particle (RP) vaccine were evaluated in chickens for their ... 6469 items, 20/Page, Page[117/324][|<<] [|<] [111] [112] [113] [114] [115] [116] [117] [118] [119] [120] [>|] [>>|] |
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