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2025-12-5 14:43:44
Article

Xiaoyi Gao, etc.,al. Hemagglutinin of Emerging Low Pathogenic Avian Influenza Viruses Underpins High Pathogenicity to Mammals. Journal of Medical Virology.  Abstract  
submitted by kickingbird at Oct, 1, 2025 from Journal of Medical Virology (via https://onlinelibrary.wiley.com/doi/10.1002/jmv.70615)
The pathogenicity of emerging early zoonotic avian H7N9 and H3N8 low-pathogenic avian influenza viruses (LPAIVs) in humans is significantly enhanced compared to that of their internal gene providers, H9N2 ...

Kaftan T, Nguyen NV, Begley J, Fashina T, Carag J,. Update on Ophthalmic Implications of Highly Pathogenic Avian Influenza A (H5N1) Virus. Pathogens. 2025; 14(9):932.  Abstract  
submitted by kickingbird at Oct, 1, 2025 from Pathogens. 2025; 14(9):932 (via https://www.mdpi.com/2076-0817/14/9/932)
Introduction: Highly Pathogenic Avian Influenza (HPAI) A(H5N1) represents a growing public health challenge, given broadening zoonotic vectors, with a previously reported human mortality rate of roughly ...

Isoda N, Hew LY, Nishikawa K, Takaya F, Shimazu Y,. Genetic Diversity of Highly Pathogenic Avian Influenza Viruses Isolated in Hokkaido, Japan, During Winter 2024~2025. Pathogens. 2025; 14(9):951.  Abstract  
submitted by kickingbird at Oct, 1, 2025 from Pathogens. 2025; 14(9):951 (via https://www.mdpi.com/2076-0817/14/9/951)
Genetic and antigenic analyses were performed on highly pathogenic avian influenza viruses (HPAIVs) isolated in Hokkaido, northern Japan, during the winter of 2024–2025. Ninety-eight HPAIVs were isolated ...

Iancu I, B?rbuceanu F, T?rziu E, Pascu C, Costinar. Determination of H5N1 Avian Influenza Virus Persistence Following a 2024 Backyard Poultry Outbreak in Romania. Veterinary Sciences. 2025; 12(10):922.  Abstract  
submitted by kickingbird at Oct, 1, 2025 from Veterinary Sciences. 2025; 12(10):922 (via https://www.mdpi.com/2306-7381/12/10/922)
In November 2024, an outbreak of highly pathogenic avian influenza (HPAI) H5N1 was confirmed in backyard poultry in Timi? County, Western Romania. The index cases involved chickens and domestic geese found ...

Tsafack DT, Monamele CG, Moumbeket-Yifomnjou MH, M. Evolving Dynamics of Whole-Genome Influenza A/H3N2 Viruses Isolated in Cameroon. Adv Virol. 2025 Sep 19;2025:3668615.  Abstract  
submitted by kickingbird at Sep, 30, 2025 from Adv Virol. 2025 Sep 19;2025:3668615 (via https://onlinelibrary.wiley.com/doi/10.1155/av/3668615)
Background: Since 2023, Cameroon has recorded numerous cases of seasonal influenza caused by the A/H3N2 subtype, which is the strain most commonly encountered worldwide in 2024. Methods: To describe the ...

Kim D, Loeffler K, Hu Y, Arsiwala A, Frey S, Mural. Tethered Antigenic Suppression Shields the Hemagglutinin Head Domain and Refocuses the Antibody Response to the Stalk Domain. Chemistry (Basel). 2025 Feb;7(1):12.  Abstract  
submitted by kickingbird at Sep, 30, 2025 from Chemistry (Basel). 2025 Feb;7(1):12 (via https://www.mdpi.com/2624-8549/7/1/12)
Influenza has been a global health concern for the past century. Current seasonal influenza vaccines primarily elicit an antibody response that targets the immunodominant head domain of the viral glycoprotein ...

Licheri M, Mwanga M, Licheri MF, Graaf-Rau A, S?ge. Optimized high-throughput whole-genome sequencing workflow for surveillance of influenza A virus. Genome Med. 2025 Sep 26;17(1):103.  Abstract  
submitted by kickingbird at Sep, 28, 2025 from Genome Med. 2025 Sep 26;17(1):103 (via https://genomemedicine.biomedcentral.com/articles/10.1186/s1)
Whole-genome sequencing (WGS) is essential for monitoring the genetic diversity of influenza A virus (IAV) across host species. We optimized a multisegment RT-PCR (mRT-PCR) protocol to enhance amplification ...

Djurdjevi? B, Samojlovi? M, Lupulovi? D, Petrovi?. Temporal Dynamics and Surveillance of Highly Pathogenic H5 Avian Influenza in Wild Birds in Northern Serbia (2016-2025). Vet Sci. 2025 Sep 15;12(9):894.  Abstract  
submitted by kickingbird at Sep, 28, 2025 from Vet Sci. 2025 Sep 15;12(9):894 (via https://www.mdpi.com/2306-7381/12/9/894)
Wild birds, particularly migratory waterfowl (family Anatidae), are the primary reservoir of avian influenza viruses, playing a key role in their transboundary spread. In the winter of 2016/2017, the H5N8 ...

Klivleyeva N, Glebova T, Saktaganov N, Webby R. Cases of Interspecies Transmission of Influenza A Virus from Swine to Humans. Vet Sci. 2025 Sep 9;12(9):873.  Abstract  
submitted by kickingbird at Sep, 28, 2025 from Vet Sci. 2025 Sep 9;12(9):873 (via https://www.mdpi.com/2306-7381/12/9/873)
Influenza A viruses infect many animal species and have great zoonotic potential. The epidemiology of swine influenza worldwide is of particular importance because the pig can act as a "mixing vessel" ...

Tai-Jung Li, Kuan-Fu Chen, Andrew Pekosz, Yu-Nong. Visualizing and Deciphering Influenza A(H1N1) pdm09 Reassortment in the 2019-2023 Seasons. Virus Evolution, veaf070.  Abstract  
submitted by kickingbird at Sep, 28, 2025 from Virus Evolution, veaf070 (via https://academic.oup.com/ve/advance-article/doi/10.1093/ve/v)
Influenza A viruses remain a persistent public health concern due to their extensive genomic diversity and seasonality. Among the mechanisms driving their evolution, reassortment plays a pivotal role by ...

Shuk Hang Li, etc.,al. [preprint]Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses. https://doi.org/10.1101/2025.09.24.25335646.  Abstract  
submitted by kickingbird at Sep, 28, 2025 from https://doi.org/10.1101/2025.09.24.25335646 (via https://www.medrxiv.org/content/10.1101/2025.09.24.25335646v)
Influenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with ...

Kim YI, Jang SG, Kwon W, Kim J, Park D, Choi I, Ch. PB2 and NP of North American H5N1 virus drive immune cell replication and systemic infections. Sci Adv. 2025 Sep 26;11(39):eady1208.  Abstract  
submitted by kickingbird at Sep, 27, 2025 from Sci Adv. 2025 Sep 26;11(39):eady1208 (via https://www.science.org/doi/10.1126/sciadv.ady1208)
The 2022 North American outbreak of 2.3.4.4b H5N1 avian influenza virus revealed substantial mammalian adaptation and pathogenicity, yet mechanisms remain unclear. To address this knowledge gap, we investigated ...

Brigleb PH, Roubidoux EK, Lazure L, Livingston B,. Repeated oral exposure to H5N1 influenza virus in pasteurized milk does not cause adverse responses to subsequent influenza infection. Sci Adv. 2025 Sep 26;11(39):eaeb3906.  Abstract  
submitted by kickingbird at Sep, 27, 2025 from Sci Adv. 2025 Sep 26;11(39):eaeb3906 (via https://www.science.org/doi/10.1126/sciadv.aeb3906)
In March 2024, a highly pathogenic avian influenza H5N1 (HPAI) clade 2.3.4.4b virus was identified in US dairy cows, with spillover to cats, poultry, and humans. Up to 30% of commercial pasteurized milk ...

Lee J, Lee CW, Lee S, Ibrahim S, Suarez DL, Spackm. The Efficacy of Inactivated Vaccine Against H5 Clade 2.3.4.4b Highly Pathogenic Avian Influenza Virus in Turkeys. Avian Dis. 2025 Sep;69(3):288-294.  Abstract  
submitted by kickingbird at Sep, 27, 2025 from Avian Dis. 2025 Sep;69(3):288-294 (via https://bioone.org/journals/avian-diseases/volume-69/issue-3)
The global outbreak of clade 2.3.4.4b H5 highly pathogenic avian influenza (HPAI) has caused tremendous losses in poultry worldwide. Although turkeys are a smaller sector in poultry production compared ...

Verma AK, Kumar M, Murugkar HV, Nagarajan S, Tosh. Evaluation of In-Contact Transmission Potential of H5N1 Avian Influenza Virus in House Crows (Corvus splendens). Avian Dis . 2025 Sep;69(3):237-242..  Abstract  
submitted by kickingbird at Sep, 27, 2025 from Avian Dis . 2025 Sep;69(3):237-242. (via https://bioone.org/journals/avian-diseases/volume-69/issue-3)
We evaluated the infection and transmission potential of the highly pathogenic avian influenza (HPAI) H5N1 virus from infected crows (Corvus splendens) to healthy in-contact crows. Six crows were inoculated ...

Yixi Wu, Minke Li, Huanhuan Li, Tianli sun, Yifan. [preprint]Cryo-EM structure of influenza polymerase bound to the cRNA promoter provides insights into the mechanism of virus replication. https://doi.org/10.1101/2025.09.23.677976.  Abstract  
submitted by kickingbird at Sep, 27, 2025 from https://doi.org/10.1101/2025.09.23.677976 (via https://www.biorxiv.org/content/10.1101/2025.09.23.677976v1)
Influenza virus polymerase (FluPol) synthesizes the complementary RNA (cRNA) and the viral RNA (vRNA) using distinct de novo initiation strategies during genome replication, known as internal and terminal ...

Alkie TN, Embury-Hyatt C, Signore AV, Ramos D, Mof. Dairy cow- and avian-origin clade 2.3.4.4b H5N1 induce severe mastitis in lactating goats and transmission to suckling goats. Cell Rep . 2025 Sep 24;44(10):116346..  Abstract  
submitted by kickingbird at Sep, 26, 2025 from Cell Rep . 2025 Sep 24;44(10):116346. (via https://www.cell.com/cell-reports/fulltext/S2211-1247(25)011)
The emergence of highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b has led to unprecedented spillover and spread among US dairy cows, raising concerns about transmission to other ruminants. ...

Chavoix C, Massin P, Briand FX, Louboutin K, Busso. Identification of H1N2 influenza viruses in turkeys after spillover from swine and in vitro characterization. Virus Res. 2025 Sep 21:199634.  Abstract  
submitted by kickingbird at Sep, 25, 2025 from Virus Res. 2025 Sep 21:199634 (via https://www.sciencedirect.com/science/article/pii/S016817022)
Influenza A viruses (IAVs) circulate among animals and humans and can cross species barriers to adapt to new hosts. In France, since 2020, a new genotype named H1avN2#E has predominated in pig farms. In ...

Wang Y, Gao YD, Jiang CH, Xi Y, Yang MX, Zhang W,. Characterisation of a novel chicken-derived H3N3 avian influenza virus detected in China in 2023: Pathogenicity and immunogenicity. PLoS One. 2025 Sep 23;20(9):e0332213.  Abstract  
submitted by kickingbird at Sep, 25, 2025 from PLoS One. 2025 Sep 23;20(9):e0332213 (via https://journals.plos.org/plosone/article?id=10.1371/journal)
The poultry industry faces a constant threat from the mutation and transmission of avian influenza viruses (AIVs). While waterfowl and wild birds are natural hosts of H3N3 AIV, reports of H3N3 infections ...

Zhu B, Fung K, Feng HH, Beatty JA, Hill F, Tse ACN. The hemagglutinin proteins of clades 1 and 2.3.4.4b H5N1 highly pathogenic avian influenza viruses exhibit comparable attachment patterns to avian and mammalian tissues. J Virol. 2025 Sep 23:e0097625.  Abstract  
submitted by kickingbird at Sep, 25, 2025 from J Virol. 2025 Sep 23:e0097625 (via https://journals.asm.org/doi/10.1128/jvi.00976-25)
The global spread of the A/goose/Guangdong/1/96-lineage H5N1 highly pathogenic avian influenza (HPAI) viruses has been accompanied by an expanded host range and the establishment of sustained viral transmission ...

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