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2024-3-28 19:37:09
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Gao J, Wei J, Qin S, Liu S, Mo S, Long Q, Tan S, L. Exploring the global immune landscape of peripheral blood mononuclear cells in H5N6-infected patient with single-cell transcriptomics. BMC Med Genomics. 2023 Oct 18;16(1):249.  Abstract  
submitted by kickingbird at Oct, 19, 2023 from BMC Med Genomics. 2023 Oct 18;16(1):249 (via https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s1)
Background: Avian influenza viruses (AIV), particularly H5N6, have risen in infection frequency, prompting major concerns. Single-cell RNA sequencing (scRNA-seq) can illustrate the immune cell landscape ...

Gaide N, Filaire F, Bertran K, Crispo M, Dirat M,. The Feather Epithelium Contributes to the Dissemination and Ecology of clade 2.3.4.4b H5 High Pathogenicity Avian Influenza Viruses in Ducks. Emerg Microbes Infect. 2023 Oct 17:2272644..  Abstract  
submitted by kickingbird at Oct, 18, 2023 from Emerg Microbes Infect. 2023 Oct 17:2272644. (via https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2)
Immature feathers are known replication sites for high pathogenicity avian influenza viruses (HPAIVs) in poultry. However, it is unclear whether feathers play an active role in viral transmission. This ...

Liang CY, Huang I, Han J, Sownthirarajan B, Kulhan. Avian influenza A viruses exhibit plasticity in sialylglycoconjugate receptor usage in human lung cells. J Virol. 2023 Oct 16:e0090623.  Abstract  
submitted by kickingbird at Oct, 17, 2023 from J Virol. 2023 Oct 16:e0090623 (via https://journals.asm.org/doi/10.1128/jvi.00906-23)
Influenza A viruses (IAV) utilize sialic acid (Sia) containing cell surface glycoconjugates for host cell infection, and IAV strains from different host species show preferences for structurally distinct ...

Li M, Wang W, Chen J, Zhan Z, Xu M, Liu N, Ren L,. Transplacental transfer efficiency of maternal antibodies against influenza A(H1N1)pdm09 virus and dynamics of naturally acquired antibodies in Chinese children: a longitudinal, paired mother-neonate. Lancet Microbe. 2023 Oct 9:S2666-5247(23)00181-7.  Abstract  
submitted by kickingbird at Oct, 16, 2023 from Lancet Microbe. 2023 Oct 9:S2666-5247(23)00181-7 (via https://www.thelancet.com/journals/lanmic/article/PIIS2666-5)
Background: The 2009 pandemic H1N1 influenza A virus (A(H1N1)pdm09 virus) evolves rapidly and has continued to cause severe infections in children since its emergence in 2009. We aimed to characterise ...

Cui P, Shi J, Yan C, Wang C, Zhang Y, Zhang Y, Xin. Analysis of avian influenza A (H3N8) viruses in poultry and their zoonotic potential, China, September 2021 to May 2022. Euro Surveill. 2023 Oct;28(41):2200871.  Abstract  
submitted by kickingbird at Oct, 16, 2023 from Euro Surveill. 2023 Oct;28(41):2200871 (via https://www.eurosurveillance.org/content/10.2807/1560-7917.E)
BackgroundTwo human cases of avian influenza A (H3N8) virus infection were reported in China in 2022.AimTo characterise H3N8 viruses circulating in China in September 2021-May 2022.MethodsWe sampled poultry ...

Khan Y, Kassymbekov Y, Suleimenova S, Karamendin K. Genome sequence of equine influenza virus isolated from horses in southeast Kazakhstan in 2020. Microbiol Resour Announc. 2023 Oct 12:e0043323.  Abstract  
submitted by kickingbird at Oct, 16, 2023 from Microbiol Resour Announc. 2023 Oct 12:e0043323 (via https://journals.asm.org/doi/10.1128/mra.00433-23)
An influenza virus strain, A/equine/Almaty/268/2020, was isolated from horses in southeast Kazakhstan in 2020. Here, we present the nearly complete genome sequence of this epidemic strain. This study was ...

Pleros C, Adamidis K, Kantartzi K, Griveas I, Balt. Dialysis Patients Respond Adequately to Influenza Vaccination Irrespective of Dialysis Modality and Chronic Inflammation. J Clin Med. 2023 Sep 26;12(19):6205.  Abstract  
submitted by kickingbird at Oct, 16, 2023 from J Clin Med. 2023 Sep 26;12(19):6205 (via https://www.mdpi.com/2077-0383/12/19/6205)
(1) Background: Chronic inflammation and suboptimal immune responses to vaccinations are considered to be aspects of immune dysregulation in patients that are undergoing dialysis. The present study aimed ...

Dai M, Zhu S, An Z, You B, Li Z, Yao Y, Nair V, Li. Dissection of key factors correlating with H5N1 avian influenza virus driven inflammatory lung injury of chicken identified by single-cell analysis. PLoS Pathog. 2023 Oct 11;19(10):e1011685.  Abstract  
submitted by kickingbird at Oct, 12, 2023 from PLoS Pathog. 2023 Oct 11;19(10):e1011685 (via https://journals.plos.org/plospathogens/article?id=10.1371/j)
Chicken lung is an important target organ of avian influenza virus (AIV) infection, and different pathogenic virus strains lead to opposite prognosis. Using a single-cell RNA sequencing (scRNA-seq) assay, ...

Sheppard CM, Goldhill DH, Swann OC, Staller E, Pen. An Influenza A virus can evolve to use human ANP32E through altering polymerase dimerization. Nat Commun. 2023 Oct 10;14(1):6135.  Abstract  
submitted by kickingbird at Oct, 12, 2023 from Nat Commun. 2023 Oct 10;14(1):6135 (via https://www.nature.com/articles/s41467-023-41308-4)
Human ANP32A and ANP32B are essential but redundant host factors for influenza virus genome replication. While most influenza viruses cannot replicate in edited human cells lacking both ANP32A and ANP32B, ...

Idoko-Akoh A, Goldhill DH, Sheppard CM, Bialy D, Q. Creating resistance to avian influenza infection through genome editing of the ANP32 gene family. Nat Commun. 2023 Oct 10;14(1):6136.  Abstract  
submitted by kickingbird at Oct, 12, 2023 from Nat Commun. 2023 Oct 10;14(1):6136 (via https://www.nature.com/articles/s41467-023-41476-3)
Chickens genetically resistant to avian influenza could prevent future outbreaks. In chickens, influenza A virus (IAV) relies on host protein ANP32A. Here we use CRISPR/Cas9 to generate homozygous gene ...

Carnaccini S, Cáceres CJ, Gay LC, Ferreri LM, Skep. Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail ( Coturnix c. japonica). J Virol. 2023 Oct 6:e0074323.  Abstract  
submitted by kickingbird at Oct, 7, 2023 from J Virol. 2023 Oct 6:e0074323 (via https://journals.asm.org/doi/10.1128/jvi.00743-23)
Influenza A viruses (FLUAV) of the H9N2 subtype are zoonotic pathogens that cause significant economic damage to the poultry industry. Vaccination to prevent and control H9N2 infections in poultry is widely ...

McMahon M, Tan J, O´Dell G, Kirkpatrick Roub. Immunity induced by vaccination with recombinant influenza B virus neuraminidase protein breaks viral transmission chains in guinea pigs in an exposure intensity-dependent manner. J Virol. 2023 Oct 6:e0105723.  Abstract  
submitted by kickingbird at Oct, 7, 2023 from J Virol. 2023 Oct 6:e0105723 (via https://journals.asm.org/doi/10.1128/jvi.01057-23)
Mucosal vaccines and vaccines that block pathogen transmission are under-appreciated in vaccine development. However, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has shown ...

Lebarbenchon C, Boucher S, Feare C, Dietrich M, La. Migratory patterns of two major influenza virus host species on tropical islands. R Soc Open Sci. 2023 Oct 4;10(10):230600.  Abstract  
submitted by kickingbird at Oct, 7, 2023 from R Soc Open Sci. 2023 Oct 4;10(10):230600 (via https://royalsocietypublishing.org/doi/10.1098/rsos.230600)
Animal migration is a major driver of infectious agent dispersal. Duck and seabird migrations, for instance, play a key role in the spatial transmission dynamics and gene flow of avian influenza viruses ...

Kikuchi C, Antonopoulos A, Wang S, Maemura T, Kara. Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines. Nat Commun. 2023 Oct 4;14(1):6178.  Abstract  
submitted by kickingbird at Oct, 5, 2023 from Nat Commun. 2023 Oct 4;14(1):6178 (via https://www.nature.com/articles/s41467-023-41908-0)
Evolution of human H3N2 influenza viruses driven by immune selection has narrowed the receptor specificity of the hemagglutinin (HA) to a restricted subset of human-type (Neu5Acα2-6 Gal) glycan receptors ...

Sumner KM, Masalovich S, O´Halloran A, Holst. Severity of influenza-associated hospitalisations by influenza virus type and subtype in the USA, 2010-19: a repeated cross-sectional study. Lancet Microbe. 2023 Sep 25:S2666-5247(23)00187-8.  Abstract  
submitted by kickingbird at Oct, 1, 2023 from Lancet Microbe. 2023 Sep 25:S2666-5247(23)00187-8 (via https://www.thelancet.com/journals/lanmic/article/PIIS2666-5)
Background: Influenza burden varies across seasons, partly due to differences in circulating influenza virus types or subtypes. Using data from the US population-based surveillance system, Influenza Hospitalization ...

Andreev K, Jones JC, Seiler P, Kandeil A, Turner J. Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Circulating Globally in 2022-2023. J Infect Dis. 2023 Sep 28:jiad418.  Abstract  
submitted by kickingbird at Oct, 1, 2023 from J Infect Dis. 2023 Sep 28:jiad418 (via https://academic.oup.com/jid/advance-article-abstract/doi/10)
The antiviral susceptibility of currently circulating (2022-2023) highly pathogenic avian influenza (HPAI) A(H5N1) viruses was assessed by genotypic and phenotypic approaches. The frequency of neuraminidase ...

Barkhasbaatar A, Gilbert M, Fine AE, Shiilegdamba. Ecological characterization of 175 low-pathogenicity avian influenza viruses isolated from wild birds in Mongolia, 2009-2013 and 2016-2018. Vet Med Sci. 2023 Sep 28.  Abstract  
submitted by kickingbird at Oct, 1, 2023 from Vet Med Sci. 2023 Sep 28 (via https://onlinelibrary.wiley.com/doi/10.1002/vms3.1281)
Background: Since 2005, highly pathogenic avian influenza A H5N1 viruses have spread from Asia worldwide, infecting poultry, humans and wild birds. Subsequently, global interest in avian influenza (AI) ...

Lei Y, Sun Y, Wu W, Liu H, Wang X, Shu Y, Fang S. Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro. Virol J. 2023 Sep 29;20(1):219.  Abstract  
submitted by kickingbird at Oct, 1, 2023 from Virol J. 2023 Sep 29;20(1):219 (via https://virologyj.biomedcentral.com/articles/10.1186/s12985-)
Influenza H7N9 virus causes human infections with about 40% case fatality rate. The severe cases usually present with pneumonia; however, some present with central nervous system complications. Pneumonia ...

Wang S, Zhang TH, Hu M, Tang K, Sheng L, Hong M, C. Deep mutational scanning of influenza A virus neuraminidase facilitates the identification of drug resistance mutations in vivo. mSystems. 2023 Sep 29:e0067023.  Abstract  
submitted by kickingbird at Oct, 1, 2023 from mSystems. 2023 Sep 29:e0067023 (via https://journals.asm.org/doi/10.1128/msystems.00670-23)
Neuraminidase (NA) is a pivotal surface enzyme and a key therapeutic target in combating the influenza A virus. Its evolution can lead to potential zoonotic transmission, seasonal epidemics, and the emergence ...

Petrich A, Chiantia S. Influenza A Virus Infection Alters Lipid Packing and Surface Electrostatic Potential of the Host Plasma Membrane. Viruses. 2023 Aug 29;15(9):1830.  Abstract  
submitted by kickingbird at Sep, 29, 2023 from Viruses. 2023 Aug 29;15(9):1830 (via https://www.mdpi.com/1999-4915/15/9/1830)
The pathogenesis of influenza A viruses (IAVs) is influenced by several factors, including IAV strain origin and reassortment, tissue tropism and host type. While such factors were mostly investigated ...

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