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2025-12-5 14:43:53
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Liao, Y., Liu, J., Wang, P., Mok, B. W. Y., & Chen. Influenza NS1 Drives N6-Methyladenosine (m6A)-Mediated Autoregulation of Viral mRNA Splicing. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at Oct, 10, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
Influenza A virus replication requires precise balance between unspliced and spliced viral mRNAs. However, the regulatory mechanisms governing viral mRNA splicing remain poorly understood. In this study, ...

Su, A., Yan, M., Herrler, G., & Becher, P. Efficient replication of avian, porcine and human influenza A viruses in well-differentiated bovine airway epithelial cells. Emerging Microbes & Infections.  Abstract  
submitted by kickingbird at Oct, 10, 2025 from Emerging Microbes & Infections (via https://www.tandfonline.com/doi/full/10.1080/22221751.2025.2)
We report that differentiated bovine airway epithelial cells are susceptible to avian, swine, and human influenza A viruses. This indicates that cows are a potential host of avian and mammalian influenza ...

Sun H, Zou J, Tu S, Luo D, Xiao R, Du Y, Xiong C,. Genome-wide CRISPR screen identifies STK11 as a critical regulator of sialic acid clusters important for influenza A virus attachment. J Adv Res. 2025 Oct 6:S2090-1232(25)00763-5.  Abstract  
submitted by kickingbird at Oct, 10, 2025 from J Adv Res. 2025 Oct 6:S2090-1232(25)00763-5 (via https://www.sciencedirect.com/science/article/pii/S209012322)
Introduction: Swine influenza virus (SIV) is a highly contagious respiratory pathogen in pigs that causes substantial economic losses in the pig industry. Importantly, pigs act as "mixing vessels" for ...

Schlachter AD, Bruno-McClung E, Díaz-Delgado J, Od. Feline high pathogenicity avian influenza H5N1 infection: past and present. J Feline Med Surg. 2025 Oct;27(10):1098612X2513706.  Abstract  
submitted by kickingbird at Oct, 10, 2025 from J Feline Med Surg. 2025 Oct;27(10):1098612X2513706 (via https://journals.sagepub.com/doi/10.1177/1098612X251370695)
Since 2020, the emergence and global dissemination of high pathogenicity avian influenza (HPAI) H5Nx clade 2.3.4.4b infection has had devastating effects in wild and domestic bird populations, and resulted ...

Kwa?nik M, Rola J, Larska M, Ro?ek W. Serological evidence of influenza D virus circulation among cattle in Poland. J Vet Res. 2025 Sep 9;69(3):305-311.  Abstract  
submitted by kickingbird at Oct, 10, 2025 from J Vet Res. 2025 Sep 9;69(3):305-311 (via https://reference-global.com/article/10.2478/jvetres-2025-00)
Introduction: The circulation of influenza D virus (IDV) has been confirmed in Europe, North America, Asia and Africa through seroprevalence and molecular studies, as well as by virus isolation. Its broad ...

David W. Hawman et al. A replicating RNA vaccine protects cynomolgus macaques against lethal clade 2.3.4.4b influenza A H5N1 virus challenge. Sci. Transl. Med.17,eadw4646 (2025).  Abstract  
submitted by kickingbird at Oct, 9, 2025 from Sci. Transl. Med.17,eadw4646 (2025) (via https://www.science.org/doi/10.1126/scitranslmed.adw4646)
In early 2024, clade 2.3.4.4b highly pathogenic avian influenza (HPAI) A H5N1 virus was detected in United States dairy cattle. Although so far the public health threat of contemporary clade 2.3.4.4b H5N1 ...

Ismaila Shittu, etc.,al. [preprint]Sustained High Levels of Antibodies to Avian Influenza Virus H5N1 Clade 2.3.4.4b in Naturally Infected Cattle. https://doi.org/10.21203/rs.3.rs-7274486/v1.  Abstract  
submitted by kickingbird at Oct, 9, 2025 from https://doi.org/10.21203/rs.3.rs-7274486/v1 (via https://www.researchsquare.com/article/rs-7274486/v1)
Cattle were not previously thought susceptible to highly pathogenic avian influenza (HPAI) H5N1 virus infection until March 2024, when outbreaks were reported among dairy cattle. Data are sparse regarding ...

Diletta Fornasiero, etc.,al. [preprint]Continuous phylogeography reveals shifting environmental drivers of Highly Pathogenic Avian Influenza H5 spread. https://doi.org/10.21203/rs.3.rs-7636570/v1.  Abstract  
submitted by kickingbird at Oct, 9, 2025 from https://doi.org/10.21203/rs.3.rs-7636570/v1 (via https://www.researchsquare.com/article/rs-7636570/v1)
The ongoing global spread of highly pathogenic avian influenza (HPAI) continues causing major impacts on poultry, wildlife, and public health. Among the most affected countries in Europe, Italy experienced ...

Clessin, A., Briand, FX., Tornos, J. et al. Circumpolar spread of avian influenza H5N1 to southern Indian Ocean islands. Nat Commun 16, 8463 (2025).  Abstract  
submitted by kickingbird at Oct, 9, 2025 from Nat Commun 16, 8463 (2025) (via https://link.springer.com/article/10.1038/s41467-025-64297-y)
Since 2020, the outbreak of high pathogenicity avian influenza (HPAI) H5N1 virus clade 2.3.4.4b has turned into the largest documented panzootic 1,3. Here, we describe its arrival into the Indian Ocean ...

Nooruzzaman, M., de Oliveira, P.S.B., Butt, S.L. e. H5N1 influenza virus stability and transmission risk in raw milk and cheese. Nat Med (2025).  Abstract  
submitted by kickingbird at Oct, 9, 2025 from Nat Med (2025) (via https://link.springer.com/article/10.1038/s41591-025-04010-0)
Highly pathogenic avian influenza H5N1 viruses have recently spread to dairy cattle, with high levels of virus detected in milk from affected animals, raising concern about the risk posed by unpasteurized ...

Barre RS, Mostafa A, Chiem K, Pearl RL, Platt RN,. Bioluminescent reporter influenza A viruses to track viral infections. Microbiol Spectr 0:e02150-25.  Abstract  
submitted by kickingbird at Oct, 8, 2025 from Microbiol Spectr 0:e02150-25 (via https://journals.asm.org/doi/10.1128/spectrum.02150-25)
Influenza A viruses (IAVs) infect a wide range of mammalian and bird species and are responsible for seasonal outbreaks and occasional pandemics of great consequences in humans. Studying IAVs requires ...

Sally M Kephart, etc.,al. [preprint]Host Switching Mutations in H5N1 Influenza Hemagglutinin Suppress Site-specific Activation Dynamics. https://doi.org/10.1101/2025.10.06.680362.  Abstract  
submitted by kickingbird at Oct, 8, 2025 from https://doi.org/10.1101/2025.10.06.680362 (via https://www.biorxiv.org/content/10.1101/2025.10.06.680362v1)
Increase in the occurrence of human H5N1 spillover infections resulting from dissemination of highly pathogenic avian influenza (HPAI) virus into bird and mammal populations raises concerns about HPAI ...

Hada A, Xiao Z. T Cell Responses to Influenza Infections in Cattle. Viruses. 2025; 17(8):1116.  Abstract  
submitted by kickingbird at Oct, 7, 2025 from Viruses. 2025; 17(8):1116 (via https://www.mdpi.com/1999-4915/17/8/1116)
Influenza viruses are major threats to global health, with potential to cause widespread disease in both humans and animals. Cattle, once considered resistant, are susceptible hosts for multiple influenza ...

Rosemary Anna Blake, etc.,al. [preprint]Identification of key host genes for influenza A virus in avian cells using a genome-wide CRISPR-Cas9 screen. https://doi.org/10.1101/2025.10.03.680283.  Abstract  
submitted by kickingbird at Oct, 6, 2025 from https://doi.org/10.1101/2025.10.03.680283 (via https://www.biorxiv.org/content/10.1101/2025.10.03.680283v1)
Influenza A virus (IAV) causes major economic losses to the poultry industry and poses a zoonotic threat to human health. Potential pandemic outbreaks are underpinned by the ability of the virus to jump ...

Sare Golpasand et al. Exploring the molecular and biological mechanisms of host response in chickens infected with highly pathogenic avian influenza virus (H5N1): An integrative transcriptomic analysis. PLoS One. 2025.  Abstract  
submitted by kickingbird at Oct, 5, 2025 from PLoS One. 2025 (via https://pubmed.ncbi.nlm.nih.gov/41042757/)
The H5N1 strain of highly pathogenic avian influenza (HPAI) has raised worldwide alarm, posing a threat to the health of both animals and humans. The study aimed to identify key genes and biological pathways ...

Anne Günther, etc.,al. [preprint]Opportunity Drives Spillover: Serological Surveillance across Carnivores, Omnivores and Herbivores in an HPAIV H5 Hotspot in North-East Germany, 2023-2025. https://doi.org/10.1101/2025.09.30.678011.  Abstract  
submitted by kickingbird at Oct, 4, 2025 from https://doi.org/10.1101/2025.09.30.678011 (via https://www.biorxiv.org/content/10.1101/2025.09.30.678011v1)
In North-East Germany's offshore islands and mainland coast, wild ruminants, boar, and carnivores were tested for H5-HPAI antibodies. Wild ruminants were seronegative; 3.5% of boar and 12.5-21.9% of carnivores ...

Valerie Le Sage, etc.,al. [preprint]Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk. https://doi.org/10.1101/2025.10.02.679960.  Abstract  
submitted by kickingbird at Oct, 4, 2025 from https://doi.org/10.1101/2025.10.02.679960 (via https://www.biorxiv.org/content/10.1101/2025.10.02.679960v1)
In China, low pathogenic avian influenza (LPAI) H3N8 virus is widespread among chickens and has recently caused three zoonotic infections, with the last one in 2023 being fatal. Here we evaluated the relative ...

Pablo Plaza, etc.,al. Wild Birds Affected by Highly Pathogenic Avian Influenza A (H5N1) Worldwide: Epidemiological Insights Into the Recent Panzootic. Global Change Biology.  Abstract  
submitted by kickingbird at Oct, 3, 2025 from Global Change Biology (via https://onlinelibrary.wiley.com/doi/10.1111/gcb.70523)
In recent years, especially as a consequence of global change, several emerging pathogens have caused alarming effects in wild species. One of these pathogens, the Highly Pathogenic Avian Influenza A (H5N1), ...

Zhao M, Vojnits K, Lam MI, Yeo S, MacNaughton P, P. Photoinactivation of influenza viruses by modulated indoor daylight spectrum and intensity. Appl Environ Microbiol. 2025 Oct 2:e0097325.  Abstract  
submitted by kickingbird at Oct, 3, 2025 from Appl Environ Microbiol. 2025 Oct 2:e0097325 (via https://journals.asm.org/doi/10.1128/aem.00973-25)
Influenza claims over 290,000 lives annually, and the annual flu season remains a major public health challenge. Within the domain of health-focused architectural design, indoor daylight emerges as a potential ...

Bamunuarachchi G, Vaddadi K, Liang Y, Zhu Z, Dang. Tankyrases positively regulate influenza A virus replication via type I interferon response. J Virol. 2025 Oct 2:e0129825.  Abstract  
submitted by kickingbird at Oct, 3, 2025 from J Virol. 2025 Oct 2:e0129825 (via https://journals.asm.org/doi/10.1128/jvi.01298-25)
Influenza viruses are respiratory pathogens that cause both seasonal and unpredictable pandemic infections in humans. Currently approved anti-influenza drugs target the viral proteins. A recurrent mutation ...

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