Harrington WN, Brice DC, Schmitz AJ, Turner JS, Br. Broadly reactive human monoclonal antibodies targeting influenza a nucleoprotein lack protective activity in vivo. Sci Rep. 2026 Jun 16. Abstract
submitted by kickingbird at Jun, 18, 2026 from Sci Rep. 2026 Jun 16 (via https://www.nature.com/articles/s41598-026-58084-y)
The antibody response to influenza virus infection targets numerous viral proteins, with those specific for the hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins being the most extensively ... Ueki H, Tomita Y, Duong C, Mitake H, Kiso M, Furus. A CRISPR knockout mouse library for functional genomics in influenza research. Cell. 2026 Jun 16:S0092-8674(26)00591-X. Abstract
submitted by kickingbird at Jun, 18, 2026 from Cell. 2026 Jun 16:S0092-8674(26)00591-X (via https://www.cell.com/cell/abstract/S0092-8674(26)00591-X)
Functional validation of host factors in whole-animal models is a major bottleneck in virology; it hinders the translation of data from in vitro studies into a deeper understanding of the viral life cycle ... Xiang F, Xu Y, Liu C, Li X, Wang R, Zhang H, Dong. A reverse genetics-based NS1-truncated live attenuated vaccine confers broad heterologous protection against swine influenza viruses. Microb Pathog. 2026 Jun 16:108638. Abstract
submitted by kickingbird at Jun, 18, 2026 from Microb Pathog. 2026 Jun 16:108638 (via https://www.sciencedirect.com/science/article/abs/pii/S08824)
Swine influenza A viruses (swIAVs) undergo frequent reassortment and evolution, posing significant threats to both animal and human health. In this study, we employed reverse genetics to generate five ... Takahashi K, Takeda Y, Nishiyama K, Fukuyama M, Ma. Detection of H5 subtype avian influenza virus in avian oropharyngeal swab samples using a microfluidic non-competitive fluorescence polarization immunoassay. Analyst. 2026 Jun 17. Abstract
submitted by kickingbird at Jun, 18, 2026 from Analyst. 2026 Jun 17 (via https://pubs.rsc.org/en/content/articlelanding/2026/an/d6an0)
Rapid and simple methods for on-site detection of avian influenza virus (AIV) are essential for effective field surveillance. In this study, a microfluidic device-based non-competitive fluorescence polarization ... Matz HC, Yu TG, Dixit K, Kikawa C, Zhou JQ, Pena A. mRNA-based influenza vaccine expands the B cell response breadth in humans. Nat Immunol. 2026 Jun 15. Abstract
submitted by kickingbird at Jun, 17, 2026 from Nat Immunol. 2026 Jun 15 (via https://www.nature.com/articles/s41590-026-02569-5)
Conventional influenza virus vaccines induce antibody responses of limited breadth. Whether mRNA-based influenza virus vaccines can induce a superior germinal center (GC) response in humans remains unclear. ... Hastie, A., Gupta, V., Lese, P., Moya, J., Schoonb. Immunogenicity and safety of AS03-adjuvanted A/Astrakhan/3212/2020 (H5N8)-like influenza vaccine in adults: Phase 1/2, observer-blinded, randomized trial. Human Vaccines & Immunotherapeutics, 22(1). Abstract
submitted by kickingbird at Jun, 15, 2026 from Human Vaccines & Immunotherapeutics, 22(1) (via https://www.tandfonline.com/doi/full/10.1080/21645515.2026.2)
Influenza pandemics arise from novel influenza A viruses. Recent emergence of a new clade (2.3.4.4.b) of the highly pathogenic H5N1 in animals and humans highlighted its pandemic potential. We evaluated ... Chadwick C, Sparrow E, Nannei C, Taaffe J, Ampofo. Influenza Vaccine Technology Transfer: A Mixed-Methods Study with Vaccine Manufacturers and Global Experts to Assess Successes, Challenges, and Opportunities. Vaccines. 2026; 14(6):522. Abstract
submitted by kickingbird at Jun, 13, 2026 from Vaccines. 2026; 14(6):522 (via https://www.mdpi.com/2076-393X/14/6/522)
Background/Objectives: Technology transfer (TT) has been identified as a global health priority due to its impact on improving access to vaccines, including for pandemic influenza preparedness and response ... Chen T, Huang Q, Chen X, Zhu J, Kong D, Liao X, Li. Trimeric hemagglutinin vaccine provides chickens complete protection against lethal H5 subtype avian influenza virus from clade 2.3.4.4b. Emerg Microbes Infect. 2026 Dec;15(1):2678649. Abstract
submitted by kickingbird at Jun, 11, 2026 from Emerg Microbes Infect. 2026 Dec;15(1):2678649 (via https://www.tandfonline.com/doi/full/10.1080/22221751.2026.2)
H5 subtype highly pathogenic avian influenza virus (HPAIV) of clade 2.3.4.4b has prevailed globally, causing economic losses in the poultry industry and posing zoonotic threats. While inactivated vaccines ... Guo B, Li Y, Shi M, Zhang J, Wu Q, Wu X, An R, Wan. A triplex-readout CRISPR-Cas12a multimodal biosensing platform for point-of-care detection of avian influenza H5. J Hazard Mater. 2026 Jun 1;514:142562. Abstract
submitted by kickingbird at Jun, 11, 2026 from J Hazard Mater. 2026 Jun 1;514:142562 (via https://www.sciencedirect.com/science/article/pii/S030438942)
The highly pathogenic avian influenza A (H5N1) virus poses a significant zoonotic threat to public and animal health. Conventional detection methods often face limitations in complexity, time, and equipment ... Smith, E.L., Jin, Y., Miller, M.R. et al. Development of Fit-for-Purpose, High Quality Proficiency Samples for Interlaboratory Evaluation of RT-PCR Detection of HPAI H5N1 in Milk. Food Environ Virol 18, 28 (2026). Abstract
submitted by kickingbird at Jun, 9, 2026 from Food Environ Virol 18, 28 (2026) (via https://link.springer.com/article/10.1007/s12560-026-09699-x)
The increased demand for highly pathogenic avian influenza (HPAI) testing in milk highlights the critical need for well-characterized samples that enable meaningful evaluation of current detection methods. ... Abdelaal, A. M., Mahmoud, S. H., Shehata, M. R., T. Comparative immunogenicity and cross-protection of wild-type and reverse genetics H5N8 (clade 2.3.4.4b) oil-adjuvanted vaccines against circulating H5N1 avian influenza viruses from clades 2.3.4.4b an. Avian Pathology, 1–14. Abstract
submitted by kickingbird at Jun, 8, 2026 from Avian Pathology, 1–14 (via https://www.tandfonline.com/doi/full/10.1080/03079457.2026.2)
Highly pathogenic avian influenza (HPAI) H5N8 viruses of clade 2.3.4.4b continue to cause devastating outbreaks worldwide, necessitating effective vaccination strategies. The comparative efficacy of wild-type ... Bin Guo, etc.,al. A Triplex-Readout CRISPR-Cas12a Multimodal Biosensing Platform for Point-of-Care Detection of Avian Influenza H5N1. Journal of Hazardous Materials. Abstract
submitted by kickingbird at Jun, 5, 2026 from Journal of Hazardous Materials (via https://www.sciencedirect.com/science/article/abs/pii/S03043)
The highly pathogenic avian influenza A (H5N1) virus poses a significant zoonotic threat to public and animal health. Conventional detection methods often face limitations in complexity, time, and equipment ... Chenchen Feng, etc.,al. A DirectView focus reduction assay for high-throughput quantification of neutralizing antibodies against influenza A and B viruses. Cell Reports Method. Abstract
submitted by kickingbird at Jun, 5, 2026 from Cell Reports Method (via https://www.sciencedirect.com/science/article/pii/S266723752)
Robust and scalable measurement of neutralizing antibodies is critical for influenza surveillance, vaccine development, and outbreak preparedness. Although focus reduction assay (FRA) is widely used to ... Garza-Villegas MD, Luna-Cruz IE, Cavazos-Jaramillo. SPCE-Based Electrochemical Immunosensor for Influenza A (H1) Detection in Serum and Nasopharyngeal Samples. Biosensors. 2026; 16(6):312. Abstract
submitted by kickingbird at Jun, 2, 2026 from Biosensors. 2026; 16(6):312 (via https://www.mdpi.com/2079-6374/16/6/312)
Acute respiratory diseases caused by viral pathogens such as Influenza A continue to represent a major global health challenge, emphasizing the need for rapid, sensitive, and accessible diagnostic tools. ... Bihao Wu, etc.,al. A C-type single-domain antibody with protective efficacy against H1N1 via respiratory administration. Virologica Sinica. Abstract
submitted by kickingbird at May, 29, 2026 from Virologica Sinica (via https://www.sciencedirect.com/science/article/pii/S1995820X2)
Influenza A viruses, particularly H1N1, pose a significant public health threat, highlighting the continued need for novel prophylactics and therapeutics. Monoclonal antibodies are promising, but conventional ... Brian Root, etc.,al. [preprint]Predicting Influenza Virus Host Tropism and Zoonotic Spillover Risk from Protein Sequences. https://doi.org/10.64898/2026.05.21.726772. Abstract
submitted by kickingbird at May, 26, 2026 from https://doi.org/10.64898/2026.05.21.726772 (via https://www.biorxiv.org/content/10.64898/2026.05.21.726772v1)
Novel infectious diseases, predominantly originating from non-human animals, pose a significant threat to global public health and economic stability. Avian influenza virus presents an especially significant ... Pablo Puchades-Colera etc.,al. Methods for detecting highly pathogenic avian influenza H5N1 virus in dairy processing environments. Front. Microbiol.. Abstract
submitted by kickingbird at May, 25, 2026 from Front. Microbiol. (via https://www.frontiersin.org/journals/microbiology/articles/1)
The spread of highly pathogenic avian influenza (HPAI) H5N1 into mammals, including U.S. dairy cattle, underscores the need for effective surveillance in milk and environmental samples. This study evaluated ... Du X, Yuan Y, Tang C, Li Y, Guo Z, Yang Y, Yang H,. An mRNA Vaccine with Tandem Mutated HA-NA Confers Protection Against Multiple Strains of H1N1 Influenza. Vaccines. 2026; 14(5):454. Abstract
submitted by kickingbird at May, 20, 2026 from Vaccines. 2026; 14(5):454 (via https://www.mdpi.com/2076-393X/14/5/454)
Background/Objectives: Recurrent influenza epidemics impose a severe global burden, with conventional vaccines constrained by production time lags and rapid viral mutation. This study aims to explore a ... Jia L, Qiu R, et al. Evaluation of Safety and Immunogenicity of High-Dose Quadrivalent Seasonal Influenza Split Vaccine: A Preclinical Study. Vaccines. 2026; 14(5):446. Abstract
submitted by kickingbird at May, 18, 2026 from Vaccines. 2026; 14(5):446 (via https://www.mdpi.com/2076-393X/14/5/446)
Objectives: Seasonal influenza leads to substantial global morbidity and mortality, especially in adults aged 65 years and older, who present poor immune responses to standard-dose influenza vaccines. ... Zhuang, Y., Chen, L., Qin, C. et al. A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections. Sig Transduct Target Ther 11, 182 (2026). Abstract
submitted by kickingbird at May, 16, 2026 from Sig Transduct Target Ther 11, 182 (2026) (via https://link.springer.com/article/10.1038/s41392-026-02666-9)
Influenza A viruses continue to pose a major threat to global public health. In addition to H1N1 and H3N2 subtypes causing seasonal epidemics that result in an estimated 3–5 million severe cases and 290,000–650,000 ... 410 items, 20/Page, Page[3/21][|<<] [|<] [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [>|] [>>|] |
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