ANCHISI S, Guerra J, Mottet-Osman G, Garcin D, et. Mismatches in Influenza A virus vRNA panhandle prevent RIG-I sensing by impairing RNA/RIG-I complex formation. J Virol. 2015 Oct 7. pii: JVI.01671-15.
Influenza virus RNA promoter panhandle structures are believed to be sensed by RIG-I. The occurrence of mismatches in this dsRNA structure raises questions about their effect on innate sensing. Our results suggest that mismatches in vRNA promoters decrease binding to RIG-I in vivo, affecting RNA/RIG-I complex formation, and preventing RIG-I activation. These results can be inferred to apply to other viruses and suggest that mismatches may represent a general viral strategy to escape RIG-I sensing
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