SUN H, Sun Y, Pu J, Zhang Y, et al. Comparative virus replication and host innate response in human cells infected with 3 prevalent clades (2.3.4, 2.3.2 and 7) of highly pathogenic avian influenza H5N1 viruses. J Virol. 2013 Oct 16
Highly pathogenic avian influenza H5N1 virus clades 2.3.4, 2.3.2 and 7 are the dominant co-circulating H5N1 viruses in poultry in China. However, humans appear to be clinically susceptible mostly to the 2.3.4 virus clade. Here, we demonstrated that A549 cells and human macrophages infected with clade 2.3.4 viruses produced significantly more viruses than those infected with the other two clades. Likewise, clade 2.3.4 infected macrophages caused the most severe cellular damage and strongest pro-inflammatory response.
See Also:
Latest articles in those days:
- Outbreak of Highly Pathogenic Avian Influenza A(H5N1) Virus in Seals, St. Lawrence Estuary, Quebec, Canada 2 days ago
- Molecular characterization of influenza virus circulating in Nepal in the year 2019 2 days ago
- Seasonal antigenic prediction of influenza A H3N2 using machine learning 2 days ago
- Probable extinction of influenza B/Yamagata and its public health implications: a systematic literature review and assessment of global surveillance databases 2 days ago
- Code to reproduce analysis in Nguyen et al, Emergence and interstate spread of highly pathogenic avian influenza A (H5N1) in dairy cattle. 2 days ago
[Go Top] [Close Window]