LOHRMANN F, Dijkman R, Stertz S, Thiel V, et al. Emergence of a C-terminal seven amino acid elongation of NS1 around 1950 conferred a minor growth advantage to former seasonal influenza A viruses. J Virol. 2013 Aug 7.
Influenza A viruses circulating in humans from ～1950 to ～1987 featured a non-structural (NS1) protein with a C-terminal extension of seven amino acids. The biological significance of this NS1 elongation remained elusive. We observed that replication kinetics of wild-type A/Hong Kong/01/68 (H3N2) and a mutant encoding a truncated NS1 were indistinguishable in most experimental systems. However, wild-type virus out-competed the mutant during mixed infections, suggesting that the NS1 extension conferred minor growth advantages.
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