Structural basis for the function and inhibition of an influenza virus proton channel

Stouffer AL, Acharya R, Salom D, Levine AS, Di Cos. Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451, 596-599 (31 January 2008)
submited by kickingbird at Mar, 25, 2008 8:52 AM from Nature 451, 596-599 (31 January 2008)

The M2 protein from influenza A virus is a pH-activated proton channel that mediates acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90%....