To understand the evolutionary characterization of HA1 of H1N1 influenza virus HA gene circulaing from 1981 to 2005 in China,viral RNAS of 370 H1N1 strains were extracted and transcribed into cDNA by reverse transcriptase and amplified by PCR.The products of PCR were sequenced.The sequences were analyzed through biometic software.The results showed that all the four antigenic sites were mutated,bigger change occurred on the Sb and Ca sites;the 130 loop of receptor binding sites(RBS) of HA1 amino acid delete...

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