Tumpey TM, Szretter KJ, Van Hoeven N, Katz JM, Koc. The Mx1 gene protects mice against pandemic 1918 and highly lethal human H5N1 influenza viruses. J Virol. 2007 Jul 25
Mice carrying a wild-type Mx1 gene (Mx1(+/+)) differ from standard laboratory mice (Mx1(-/-)) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1(+/+) but not Mx1(-/-) mice was enhanced if the animals were treated with a single dose of exogenous interferon-alpha before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.
See Also:
Latest articles in those days:
- Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation 4 hours ago
- Advax-SM?-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines 4 hours ago
- Triggering Degradation of Host Cellular Proteins for Robust Propagation of Influenza Viruses 4 hours ago
- Influenza Virus Genomic Surveillance, Arizona, USA, 2023–2024 4 hours ago
- Detection and Characterization of Influenza A Virus Endemic Circulation in Suckling and Nursery Pigs Originating from Vaccinated Farms in the Same Production System 4 hours ago
[Go Top] [Close Window]