Avian influenza virus is acquiring the ability to cross the species barrier between the avian and mammal. However, the genetic mechanism of this ability has not been well known. Influenza A virus A/Chicken/Guangdong/04(H5N1) which was highly pathogenic to both SPF chicken and BALB/c mice, was successfully rescued by a plasmid-based reverse genetics. The rescued virus R- A/Chicken/Guangdong/04(R-CG) and the wild type A/Chicken/Guangdong/04(W-CG) shared similar biological properties such as in titers of 50% e...

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