PAN Wei-qi, etc.,al. Rescue of H5N1 Subtype Influenza Virus which Is Lethal to Mice. Journal of Agricultural Biotechnology
Avian influenza virus is acquiring the ability to cross the species barrier between the avian and mammal. However, the genetic mechanism of this ability has not been well known. Influenza A virus A/Chicken/Guangdong/04(H5N1) which was highly pathogenic to both SPF chicken and BALB/c mice, was successfully rescued by a plasmid-based reverse genetics. The rescued virus R- A/Chicken/Guangdong/04(R-CG) and the wild type A/Chicken/Guangdong/04(W-CG) shared similar biological properties such as in titers of 50% e...
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