YANG Song-tao; GAO Yu-wei, etc.,al. Mice as a Model for Studying the Avian H5N1 Influenza Virus in Mammals. Virologica Sinica
The rationale of this study was to elucidate the etiological agent characteristics and pathogenic mechanisms of the Avian H5N1 influenza virus in mammals,and to offer a platform for evaluating vaccines and drugs against AIV.Male BALB/c mice(18～20g)were anesthetized by inhalation of ether and inoculated intranasally with 0.05mL of infectious virus(A/Tiger/Harbin/01/2002)isolating from a tiger.The dose lethal to 50% of mice(MLD50)was determined by infecting groups of ten with serial 10-fold viral dilutions.Mi...
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