Savill NJ, St Rose SG, Keeling MJ, Woolhouse ME.. Silent spread of H5N1 in vaccinated poultry. Nature. 2006 Aug 17;442(7104):757.
International debate on the merits of vaccinating poultry against the H5N1 influenza A virus has raised concerns about the possibility of an increased risk of between-flock transmission before outbreaks are detected. Here we show that this ´silent spread´ can occur because of incomplete protection at the flock level, even if a vaccine is effective in individual birds. The use of unvaccinated sentinels can mitigate, although not completely eliminate, the problem.
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