Neumann G, Hatta M, Kawaoka Y. Reverse genetics for the control of avian influenza. Avian Dis. 2003;47(3 Suppl):882-7
Neumann G, Hatta M, Kawaoka Y.
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive West, Madison, WI 53706, USA.
Avian influenza viruses are major contributors to viral disease in poultry as well as humans. Outbreaks of high-pathogenicity avian influenza viruses cause high mortality in poultry, resulting in significant economic losses. The potential of avian influenza viruses to reassort with human stains resulted in global pandemics in 1957 and 1968, while the introduction of an entirely avian virus into humans claimed several lives in Hong Kong in 1997. Despite considerable research, the mechanisms that determine the pathogenic potential of a virus or its ability to cross the species barrier are poorly understood. Reverse genetics methods, i.e., methods that allow the generation of an influenza virus entirely from cloned cDNAs, have provided us with one means to address these issues. In addition, reverse genetics is an excellent tool for vaccine production and development. This technology should increase our preparedness for future influenza virus outbreaks.
- Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals 17 hours ago
- Adherence of nurses to annual seasonal influenza vaccination over a five-year period 18 hours ago
- Limited evidence for the role of environmental factors in the unusual peak of influenza in Brisbane during the 2018-2019 Australian summer 18 hours ago
- Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T cell development in mice 2 days ago
- Emergence of one novel reassortment H3N8 avian influenza virus in China, originating from North America and Eurasia 2 days ago