This report describes influenza surveillance activities in Australia in 2020 to 2021 and the impact which coronavirus disease 2019 (COVID-19) related public health and social measures (PHSMs) had on influenza notifications. Data were extracted from several sources constituting the National Influenza Surveillance Scheme. In 2020 and 2021, a range of PHSMs were instituted across Australia to reduce the spread of COVID-19. These measures had a substantial impact on influenza circulation during this time. Laboratory-confirmed influenza notifications in these years were the lowest reported to the National Notifiable Diseases Surveillance System (NNDSS) since influenza became nationally notifiable in 2001. Laboratory-confirmed influenza notification rates varied greatly between states and territories in the two-year reporting period, likely influenced by differences in the PHSMs instituted across the country. Higher influenza notification rates were observed in the 0-4 and 5-9 year age groups in 2020, while the notification rates in 2021 were very low across all age groups. In 2020, eighty-seven percent of laboratory-confirmed influenza notifications were influenza A (91.1% influenza A(unsubtyped); 7.7% A(H1N1)pdm09; 1.2% A(H3N2)) and 12.6% were influenza B. In 2021, seventy-two percent of laboratory-confirmed influenza notifications were influenza A (91.1% influenza A(unsubtyped); 8.3% A(H3N2); 1.3% A(H1N1)pdm09) and 17.3% were influenza B. Very low influenza activity was also observed in community sentinel surveillance systems. However, slight increases in influenza-like illness, still at very low rates compared to previous years, were reported by sentinel general practices, with rises observed in mid-June in both 2020 and 2021. Very few laboratory-confirmed influenza sentinel hospital admissions and deaths were reported in 2020 and 2021.