Li C, Gao W, Zhang Q, Zhang Y, Zhao B, Yang J, Qi. Fine-tuned large language models enhance influenza forecasting. Cell Rep Methods. 2026 Jul 23:101535
Influenza-like illness (ILI) remains a persistent global health challenge, necessitating accurate forecasting tools for timely public health response. This study systematically benchmarks fine-tuned large language models (LLMs), e.g., Llama2 and GPT2, for influenza surveillance forecasting in data-limited time-series settings. We develop a lightweight fine-tuning framework that adapts pre-trained LLMs using compact embedding and prediction layers and evaluate it on seven weekly aggregated real-world surveillance datasets. Despite sample sizes of only ~523 time points per region and the absence of cloud-based data transfer, fine-tuned LLMs consistently outperform SARIMA, LSTM, PatchTST, CoVTransformer, FEDformer, Time-LLM, and GPT4TS in both accuracy and stability, especially for long-term forecasts across diverse geographic settings. Even in zero-shot settings, pre-trained LLMs capture broad epidemic trends with performance comparable to SARIMA. These findings establish fine-tuned LLMs as efficient and robust forecasting tools suitable for privacy-sensitive, data-scarce public health applications.
See Also:
Latest articles in those days:
- [preprint]The mammalian-adaptive PB2-E627K substitution preserves viral fitness of clade 2.3.4.4b H5N1 HPAIV in birds 2 hours ago
- Mallard super-shedders of avian influenza exhibit distinct cloacal microbial abundance profiles 6 hours ago
- A digitally immune-optimized influenza vaccine broadly neutralizes swine and human H1N1 influenza viruses and protects from heterologous challenge 6 hours ago
- Associations between vaccine misinformation and influenza vaccine uptake: a population-based interrupted time-series study in China 7 hours ago
- Infection and transmission dynamics of bovine and human influenza A H5N1 viruses in mouse and hamster models 7 hours ago
[Go Top] [Close Window]


