Li C, Gao W, Zhang Q, Zhang Y, Zhao B, Yang J, Qi. Fine-tuned large language models enhance influenza forecasting. Cell Rep Methods. 2026 Jul 23:101535
Influenza-like illness (ILI) remains a persistent global health challenge, necessitating accurate forecasting tools for timely public health response. This study systematically benchmarks fine-tuned large language models (LLMs), e.g., Llama2 and GPT2, for influenza surveillance forecasting in data-limited time-series settings. We develop a lightweight fine-tuning framework that adapts pre-trained LLMs using compact embedding and prediction layers and evaluate it on seven weekly aggregated real-world surveillance datasets. Despite sample sizes of only ~523 time points per region and the absence of cloud-based data transfer, fine-tuned LLMs consistently outperform SARIMA, LSTM, PatchTST, CoVTransformer, FEDformer, Time-LLM, and GPT4TS in both accuracy and stability, especially for long-term forecasts across diverse geographic settings. Even in zero-shot settings, pre-trained LLMs capture broad epidemic trends with performance comparable to SARIMA. These findings establish fine-tuned LLMs as efficient and robust forecasting tools suitable for privacy-sensitive, data-scarce public health applications.
See Also:
Latest articles in those days:
- Determinants of the Seasonal Influenza Vaccination Uptake Among People Aged 50 Years or Above During and After the Pandemic: A Systematic Review 7 hours ago
- [preprint]A GIS-based framework for standardized environmental characterization in One-Health surveillance: a case study of HPAI monitoring in wetlands 7 hours ago
- First detection and transatlantic introduction of Influenza A(H3N2) subclade K (J.2.4.1) into Ecuador: insights from genomic sentinel surveillance 7 hours ago
- Assessment of influenza virus and coronavirus tropism, replication competence and disease severity in ex vivo and in vitro cultures of the human respiratory tract 1 days ago
- Characterization of bovine-derived H5N1 viruses expressing fluorescent and luminescent reporter proteins 1 days ago
[Go Top] [Close Window]


