Objective
To investigate the spatiotemporal epidemiological characteristics and temporal trends of influenza in Fujian Province, China, from 2005 to 2022.

Methods
Descriptive epidemiological methods were used to analyze the temporal, demographic, occupational, and regional distribution of influenza cases. Spatial autocorrelation analysis, trend surface analysis, and spatiotemporal scan statistics were applied to explore the spatial distribution and clustering characteristics of influenza.

Results
A total of 215,338 influenza cases were reported in Fujian Province during 2005–2022, with the incidence rate showing an overall fluctuating upward trend over time (Z?=?4.394, P?
Conclusion
Influenza in Fujian Province showed an increasing annual incidence trend, marked temporal fluctuation, and dynamic spatial clustering during 2005–2022. These findings may support more targeted influenza surveillance, prevention, and resource allocation in high-risk populations and areas.