First detected in China in 1996, highly pathogenic avian influenza viruses (HPAIV) A(H5N1) within the Goose/Guangdong1/96-lineage have genetically evolved, diverging into multiple clades. Viruses within clade 2.3.4.4b travelled via wild birds from Asia to Europe and Africa between 2016 and 2017. They returned to China in 2020 (H5N8) and 2021 (H5N1) persisting in wild bird populations, facilitating spread across all regions apart from Oceania [1]. Worryingly, H5N1 infections have been reported in mammals and humans across multiple continents. As such, these viruses pose a threat, considering the One Health perspective.