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2024-11-4 8:48:02


Ohlopkova OV, Goncharov AE, Aslanov BI, Fadeev AV,. First detection of influenza A virus subtypes H1N1 and H3N8 in the Antarctic region: King George Island, 2023. Vopr Virusol. 2024 Sep 26;69(4):377-389
submited by kickingbird at Oct, 5, 2024 23:7 PM from Vopr Virusol. 2024 Sep 26;69(4):377-389

Relevance: Influenza A virus is characterized by a segmented single-stranded RNA genome. Such organization of the virus genome determines the possibility of reassortment, which can lead to the emergence of new virus variants. The main natural reservoir of most influenza A virus subtypes are wild waterfowl. Seasonal migrations gather waterfowl from all major migration routes to nesting areas near the northern and southern polar circles. This makes intercontinental spread of influenza A viruses possible. Objective ? to conduct molecular genetic monitoring and study the phylogenetic relationships of influenza A virus variants circulating in Antarctica in 2023.

Materials and methods: We studied 84 samples of biological material obtained from birds and marine mammals in April?May 2023 in coastal areas of Antarctica. For 3 samples, sequencing was performed on the Miseq, Illumina platform and phylogenetic analysis of the obtained nucleotide sequences of the influenza A virus genomes was performed.

Results: The circulation of avian influenza virus in the Antarctic region was confirmed. Heterogeneity of the pool of circulating variants of the influenza A virus (H3N8, H1N1) was revealed. Full-length genomes of the avian influenza virus were sequenced and posted in the GISAID database (EPI_ISL_19032103, 19174530, 19174467).

Conclusion: The study of the genetic diversity of influenza A viruses circulating in the polar regions of the Earth and the identification of the conditions for the emergence of new genetic variants is a relevant task for the development of measures to prevent biological threats.

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