Lei H, Yang M, Dong Z, Hu K, Chen T, Yang L, Zhang. Indoor relative humidity shapes influenza seasonality in temperate and subtropical climates in China. Int J Infect Dis. 2022 Nov 22:S1201-9712(22)00613-
Methods: In this study, daily temperature and RH in 1558 households from March 2017 to January 2019 in five cities across both temperate and subtropical regions in China were collected. City-level outdoor temperature and RH from 2013 to 2019 was collected from the weather stations. We first estimated the effective reproduction number (Rt) of influenza, and then used time-series analyses to explore the relationship between indoor/outdoor RH/absolute humidity (AH) and Rt of influenza. Furthermore, we expanded the measured one-year indoor temperature and RH data into five years, and used same method to examine the relationship between indoor/outdoor RH and Rt of influenza.
Results: Indoor RH displayed a seasonal pattern with highs during the summer months and lows during the winter months, while outdoor RH fluctuated with no consistent pattern in subtropical regions. Rt of influenza followed a U-shaped relationship with indoor RH in both temperate and subtropical regions, while U-shaped relationship was not observed between outdoor RH and Rt. In addition, indoor RH may be a better indicator for Rt of influenza than indoor AH.
Conclusion: The findings indicated that indoor RH may be the driver of influenza seasonality in both temperate and subtropical locations in China.
- PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A 3 hours ago
- Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replication 1 days ago
- The H9N2 avian influenza virus increases APEC adhesion to oviduct epithelia by viral NS1 protein-mediated activation of the TGF-β pathway 1 days ago
- Impact of sex on humoral immunity with live influenza B virus vaccines in mice 2 days ago
- Species-specific emergence of H7 highly pathogenic avian influenza virus is driven by intrahost selection differences between chickens and ducks 3 days ago