Hofflich B, Lunardhi A, Sunku N, Tsujimoto J, Cauw. Modeling the Viral Kinetics of Influenza A During Infection in Humans. Annu Int Conf IEEE Eng Med Biol Soc. 2022 Jul;2022
This study explores the natural control system in the body for responding to exposure to the Influenza A virus. More specifically, it delves into the development of a model to simulate the responses of target uninfected cell counts, infected cell counts, and viral titers. There are two particular models of interest: a delayed model that incorporates the brief inactive period for newly infected cells, and a non-delayed model reflecting only infected cells without delay after initial infection. Both models are commonly used in the literature and the benefits of each model are studied and explained. We generate Simulink models for both the delayed and non-delayed sets of ordinary differential equations (ODEs) to simulate responses to different viral titer impulses. Additionally, this study aims to extrapolate these models to the case for a vaccinated individual. To do this, we modify the viral clearance rate and infected cell death rate of our initial model to account for the improved immune response generated by vaccines.
See Also:
Latest articles in those days:
- Highly pathogenic avian influenza as a systemic risk - implications for control and preparedness 1 days ago
- Multiple introductions and spread of novel reassortant highly pathogenic avian influenza A (H5N1) clade 2.3.4.4b viruses via wild birds, South Korea, 2024-2025 1 days ago
- [preprint]The mammalian-adaptive PB2-E627K substitution preserves viral fitness of clade 2.3.4.4b H5N1 HPAIV in birds 2 days ago
- Mallard super-shedders of avian influenza exhibit distinct cloacal microbial abundance profiles 2 days ago
- A digitally immune-optimized influenza vaccine broadly neutralizes swine and human H1N1 influenza viruses and protects from heterologous challenge 2 days ago
[Go Top] [Close Window]


