-

nihao guest [ sign in / register ]
2024-3-29 0:05:40


Hoy G, Kuan G, López R, Sánchez N, López B, Ojeda. The Spectrum of Influenza in Children. Clin Infect Dis. 2022 Sep 7:ciac734
submited by kickingbird at Sep, 8, 2022 9:51 AM from Clin Infect Dis. 2022 Sep 7:ciac734

Background: Children constitute an important component of the influenza burden and community transmission, but the frequency of asymptomatic infection and post-influenza sequelae at the community level is poorly understood.

Methods: Two community-based prospective cohort studies (2011-2020, 2017-2020) and one case-ascertained study (2012-2017) were conducted in Managua, Nicaragua.Non-immunocompromised children aged 0-14 years with ≥1 influenza infections, determined by polymerase chain reaction and hemagglutination inhibition assay, were included.

Results: A total of 1272 influenza infections occurred in the household-based portion of the study. Influenza infection was asymptomatic in 84 (6.6%) infections, and the asymptomatic fraction increased with age (1.7%, 3.5%, and 9.1% for ages 0-1, 2-4, and 5-14, respectively; p < 0.001). Of asymptomatic children, 43 (51.2%) shed virus, compared to 1099 (92.5%) symptomatic children (p < 0.001). 2140 cases of influenza occurred in the primary care portion of the study. Sequelae of influenza were rare, with the most common being pneumonia (52, 2.4%) and acute otitis media (71, 3.3%). A/H1N1 had higher age-adjusted odds of acute otitis media (OR 1.99, 95% CI 1.14-3.48; p = 0.015) and hospitalization (OR 3.73, 95% CI 1.68-8.67; p = 0.002) than A/H3N2. B/Victoria had higher age-adjusted odds of pneumonia (OR 10.99, 95% CI 1.34-90.28; p = 0.026) than B/Yamagata.

Conclusions: Asymptomatic influenza infection is much less common in children than adults, though viral shedding still occurs in asymptomatic children. Post-influenza sequelae are rare in children in the community setting, and virus strain may be important in understanding the risk of sequelae.

See Also:

Latest articles in those days:

[Go Top]    [Close Window]

Related Pages:
Learn about the flu news, articles, events and more
Subscribe to the weekly F.I.C newsletter!


  

Site map  |   Contact us  |  Term of use  |  FAQs |  粤ICP备10094839号-1
Copyright ©www.flu.org.cn. 2004-2024. All Rights Reserved. Powered by FIC 4.0.1
  Email:webmaster@flu.org.cn