Avian H10N3 influenza virus has been circulated in waterfowl and territory poultry for several decades in eastern and southern Asia. So far, there has been no reported outbreak of H10N3 avian influenza virus in poultry farm or wild field. However, the virus spillover from the natural reservoir into human is still a concern for public health. Hereby, we report the first case of human infection with avian H10N3 influenza virus