The activity of influenza A at the end of 2019 was higher than previous two years in children younger than 6 years old in Wuhan, China. The 2019-2020 winter peak of seasonal influenza preceded the COVID-19 outbreak, with a higher and earlier peak than those of the 2017-2018 and 2018-2019 seasons. We speculate this could be due to the earlier CNY holiday season in 2019-2020 than in previous two years. We compared these results with those of two previous studies to further discuss the possible interference between influenza and COVID-19 in young children.