Two different influenza A viruses have infected and spread among dogs since 2000, and both have been widespread in dogs in North America. The H3N8 canine influenza virus arose in the United States as a variant of equine influenza virus. The H3N2 canine influenza virus arose in Asia by transfer of an avian influenza virus to dogs. Both viruses cause mild respiratory disease and are associated with outbreaks in densely housed dogs or those with frequent connections to other dogs. The 2 canine influenza viruses each caused widespread epidemics over at least several years that were associated with localized outbreaks.