Hajam IA, Kim J, Lee JH. Intranasally administered polyethylenimine adjuvanted influenza M2 ectodomain induces partial protection against H9N2 influenza A virus infection in chickens. Vet Immunol Immunopathol. 2019 Mar;209:78-83.
This study aimed to investigate whether intranasally coadministered four tandem copies of extracellular domains of M2 (M2e) and polyethyleneimine (PEI), a mucosal adjuvant, can protect chickens against H9N2 influenza A virus infection. Groups of chickens were intranasally vaccinated with M2e plus PEI adjuvant, M2e alone or PEI adjuvant, and antibody (serum IgG and mucosal IgA) and cellular (CD4+ T cells and IFN-γ levels) immune responses were measured post-vaccination. We demonstrated that the chickens vaccinated with M2e plus PEI adjuvant showed significantly (p?
See Also:
Latest articles in those days:
- [preprint]Mutational fitness landscapes of diverse human influenza H1N1 neuraminidases 7 hours ago
- [preprint]A modelling challenge to improve preparedness for highly pathogenic avian influenza epidemics: objectives, design and synthetic data generation 7 hours ago
- Influenza A H1N1 Infection Triggers Endothelial Immunothrombosis via TNF-α–Tissue Factor–Thrombin Signaling in Human Brain Microvascular Endothelial Cells 8 hours ago
- Antiviral Susceptibility of Clade 2.3.4.4b H5N1 and H5N5 Influenza Viruses Detected in Birds in Russia During 2021-2022 8 hours ago
- Dairy producers´ perceptions of highly pathogenic avian influenza (HPAI) H5N1 and their influence on implementation of biosecurity changes 1 days ago
[Go Top] [Close Window]
