Nakatsukasa A, Kuruma K, Okamatsu M, Hiono T, et a. Potency of whole virus particle and split virion vaccines using dissolving microneedle against challenges of H1N1 and H5N1 influenza viruses in mice. Vaccine 2017 Apr 18.
Transdermal vaccination using a microneedle (MN) confers enhanced immunity compared with subcutaneous (SC) vaccination. Here we developed a novel dissolving MN patch for the influenza vaccine. The potencies of split virion and whole virus particle (WVP) vaccines prepared from A/Puerto Rico/8/1934 (H1N1) and A/duck/Hokkaido/Vac-3/2007 (H5N1), respectively, were evaluated. MN vaccination induced higher neutralizing antibody responses than SC vaccination in mice. Moreover, MN vaccination with a lower dose of antigens conferred protective immunity against lethal challenges of influenza viruses than SC vaccination in mice. These results suggest that the WVP vaccines administered using MN are an effective combination for influenza vaccine to be further validated in humans.
See Also:
Latest articles in those days:
- Dairy producers´ perceptions of highly pathogenic avian influenza (HPAI) H5N1 and their influence on implementation of biosecurity changes 19 hours ago
- Genetic Characterization of Highly Similar H9N2 Viruses Isolated from Swine and Poultry in China 19 hours ago
- Influenza disease burden investigation and cost-effectiveness analysis based on system dynamics model 1 days ago
- Descriptive analysis of dairy cow imports from the United States into Ontario, Canada between 2009 and 2019: implications for the risk of H5N1 introduction 1 days ago
- Pre-existing cross-subtype serological responses against H5Nx in health care workers 1 days ago
[Go Top] [Close Window]
