POHL MO, Lanz C, Stertz S. Late stages of the influenza A virus replication cycle - a tight interplay between virus and host.. J Gen Virol. 2016 Jul 22.
After successful infection and replication of its genome in the nucleus of the host cell influenza A virus faces several challenges before newly assembled viral particles can bud off from the plasma membrane, giving rise to new infectious virus. The vRNP complexes need to exit from the nucleus and be transported to the virus assembly sites at the plasma membrane. Moreover, they need to be bundled to ensure the incorporation of precisely one of each of the eight viral genome segments into newly formed viral particles. Similarly, viral envelope glycoproteins and other viral structural proteins need to be targeted to virus assembly sites for viral particles to form and bud off from the plasma membrane. During all these steps influenza A virus heavily relies on a tight interplay with its host, exploiting host cell proteins for its own purposes. In this review we summarize current knowledge on late stages of the influenza virus replication cycle, focusing on the role of host cell proteins involved in this process
See Also:
Latest articles in those days:
- Influenza D Virus Infection in China, 2022-2023 12 hours ago
- Evidence of reassortment of avian influenza A (H2) viruses in Brazilian shorebirds 12 hours ago
- Epitopes in the HA and NA of H5 and H7 avian influenza viruses that are important for antigenic drift 2 days ago
- Assessment of CD8+ T-cell mediated immunity in an influenza A(H3N2) human challenge model in Belgium: a single centre, randomised, double-blind phase 2 study 2 days ago
- Dual N-linked glycosylation at residues 133 and 158 in the hemagglutinin are essential for the efficacy of H7N9 avian influenza virus like particle vaccine in chickens and mice 2 days ago
[Go Top] [Close Window]