VIDIC J, Noiray M, Bagchi A, Slama-Schwok A, et al. Identification of a novel complex between the nucleoprotein and PA(1-27) of Influenza A virus polymerase.. Biochemistry. 2016 Jul 19.
The structure of the ribonucleoprotein complexes (RNP) is crucial to viral transcription, replication of Influenza virus but the nucleoprotein (NP) association with the polymerase remains to be characterized at the molecular level. Here, we identify a peptide of the polymerase acidic subunit PA(1-27) that associates with NP. Docking and MD simulations suggest a similar NP binding site with PA(1-27) and PA(1-186). The PA(1-27)-NP complex is characterized by surface plasmon resonance and fluorescence using recombinant NP proteins and by pull-down assays in infected cells. The PA(1-27)- NP complex may have a role in the final steps of transcription/ replication
See Also:
Latest articles in those days:
- Abundant Intra-Subtype Reassortment Revealed in H13N8 Influenza Viruses 21 hours ago
- Locations and structures of influenza A virus packaging-associated signals and other functional elements via an in silico pipeline for predicting constrained features in RNA viruses 1 days ago
- Molecular Characterization of Non-H5 and Non-H7 Avian Influenza Viruses from Non-Mallard Migratory Waterbirds of the North American Flyways, 2006~2011 1 days ago
- A case report and literature review on tocilizumab-cured acute necrotizing encephalopathy caused by influenza A virus 1 days ago
- Study on the clinical efficacy and safety of baloxavir marboxil tablets in the treatment of influenza A 1 days ago
[Go Top] [Close Window]