LLM Poon, T Song, R Rosenfeld, etc.,al. Quantifying influenza virus diversity and transmission in humans. Nature Genetics (2016)doi:10.1038/ng.3479
Influenza A virus is characterized by high genetic diversity. However, most of what is known about influenza evolution has come from consensus sequences sampled at the epidemiological scale that only represent the dominant virus lineage within each infected host. Less is known about the extent of within-host virus diversity and what proportion of this diversity is transmitted between individuals. To characterize virus variants that achieve sustainable transmission in new hosts, we examined within-host virus genetic diversity in household donor-recipient pairs from the first wave of the 2009 H1N1 pandemic when seasonal H3N2 was co-circulating. Although the same variants were found in multiple members of the community, the relative frequencies of variants fluctuated, with patterns of genetic variation more similar within than between households. We estimated the effective population size of influenza A virus across donor-recipient pairs to be approximately 100–200 contributing members, which enabled the transmission of multiple lineages, including antigenic variants
See Also:
Latest articles in those days:
- Outbreak of Highly Pathogenic Avian Influenza A(H5N1) Virus in Seals, St. Lawrence Estuary, Quebec, Canada 6 hours ago
- Molecular characterization of influenza virus circulating in Nepal in the year 2019 8 hours ago
- Seasonal antigenic prediction of influenza A H3N2 using machine learning 8 hours ago
- Probable extinction of influenza B/Yamagata and its public health implications: a systematic literature review and assessment of global surveillance databases 8 hours ago
- Code to reproduce analysis in Nguyen et al, Emergence and interstate spread of highly pathogenic avian influenza A (H5N1) in dairy cattle. 19 hours ago
[Go Top] [Close Window]