NACHBAGAUER R, Miller MS, Hai R, Ryder AB, et al. Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets. J Virol. 2015 Dec 30. pii: JVI.02481-15.
We assessed in ferrets whether influenza virus hemagglutinin stalk-based immunity provided protection against aerosol-transmitted H1N1 infection. Immunization of ferrets with a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were co-housed with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers, delayed or no virus replication at all following natural exposure to influenza virus.
See Also:
Latest articles in those days:
- Host restriction factor SAMHD1 does not restrict seasonal influenza virus replication in human epithelial or macrophage-like cells 22 minute(s) ago
- Enhancing the stability of Influenza A reporter viruses by recoding the gfp gene 33 minute(s) ago
- T cell help is a limiting factor for rare anti-influenza memory B cells to reenter germinal centers and generate potent broadly neutralizing antibodies 2 days ago
- Wild birds drive the introduction, maintenance, and spread of H5N1 clade 2.3.4.4b high pathogenicity avian influenza viruses in Spain, 2021-2022 2 days ago
- [preprint]FluNexus: a versatile web platform for antigenic prediction and visualization of influenza A viruses 2 days ago
[Go Top] [Close Window]
