In February, authorities in Spain reported a confirmed human case of swine influenza A(H1N1)v. The case, reported from the autonomous region of Catalonia, was confirmed positive for swine influenza by PCR and sequencing. According to the latest available information, the case has no known history of exposure to pigs or a contaminated environment. Cases of swine influenza have been sporadically reported in Spain and in other countries, the last case being from the autonomous region of Catalonia reported in 2024 (onset of symptoms in 2023). In Spain, a total of four human cases of swine influenza A(H1N1)v have been reported in the last 17 years, and no human to human transmission has been identified to date. A sample taken as part of the acute respiratory infections surveillance system tested positive for influenza A. Subsequent testing was positive for swine influenza A(H1N1)v at the reference laboratory of the autonomous region of Catalonia. The case remains asymptomatic, while epidemiological investigations are still ongoing.