The first case is a 52-year-old female from Zhoukou City, Henan Province, China, with onset of symptoms on 10 May 2025. The case was admitted to the hospital due to severe pneumonia on 12 May. Antiviral treatment was initiated, and she made a full recovery and was discharged on 23 May. The second case is a six-year-old male from Deyang City, Sichuan Province, China, with onset of symptoms on 14 May. His clinical status was mild. The third case is a 72-year-old female from Hengyang City, Hunan Province, China. She had onset of symptoms on 14 May 2025 and was hospitalized on 17 May 2025, due to her age, high fever and preexisting medical conditions. With antiviral treatment, the patient recovered and was discharged on 24 May. All three cases had poultry exposure, and all identified close contacts of the three cases completed 10 days of health monitoring, with no illness reported and no epidemiological link has been identified between the cases.