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REPERANT LA, Kuiken T, Grenfell BT, Osterhaus AD,. The immune response and within-host emergence of pandemic influenza virus. Lancet. 2014 Apr 24. pii: S0140-6736(13)62425-3. d.  Abstract  
submitted by kickingbird at May, 4, 2014 from Lancet. 2014 Apr 24. pii: S0140-6736(13)62425-3. d (via http://www.ncbi.nlm.nih.gov/pubmed/24767965)
Zoonotic influenza viruses that are a few mutations away from pandemic viruses circulate in animals, and can evolve into airborne-transmissible viruses in human beings. Paradoxically, such viruses only ...

DEBERGE MP, Ely KH, Enelow RI. Soluble, but Not Transmembrane, TNF-α Is Required during Influenza Infection To Limit the Magnitude of Immune Responses and the Extent of Immunopathology. J Immunol. 2014 Apr 30.  Abstract  
submitted by kickingbird at May, 4, 2014 from J Immunol. 2014 Apr 30 (via http://www.ncbi.nlm.nih.gov/pubmed/24790150)
TNF-α is a pleotropic cytokine that has both proinflammatory and anti-inflammatory functions during influenza infection. TNF-α is first expressed as a transmembrane protein that is proteolytically processed ...

HUNG JT, Tsai YC, Lin WD, Jan JT, et al. Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus. Antiviral Res. 2014 Apr 28. pii: S0166-3542(14)001.  Abstract  
submitted by kickingbird at May, 4, 2014 from Antiviral Res. 2014 Apr 28. pii: S0166-3542(14)001 (via http://www.ncbi.nlm.nih.gov/pubmed/24786174)
H5N1 influenza virus is a highly pathogenic virus, posing a pandemic threat. Previously, we showed that phenyl analogs of α-Galactosylceramide (α-GalCer) displayed greater NKT stimulation than α-GalCer. ...

Jefferson T, Jones MA, Doshi P, Del Mar CB, Heneg. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008965.  Abstract  
submitted by kickingbird at May, 4, 2014 from Cochrane Database Syst Rev. 2012 Jan 18;1:CD008965 (via http://www.ncbi.nlm.nih.gov/pubmed/22258996/)
Abstract BACKGROUND: Planning for outbreaks of influenza is a high priority public health issue for national governments. Neuraminidase inhibitors (NIs) are thought to help reduce the symptoms of ...

Shi J, Gao L, Zhu Y, Chen T, Liu Y, et al.. Investigation of Avian Influenza Infections in Wild Birds, Poultry and Humans in Eastern Dongting Lake, China. PLoS ONE 9(4): e95685. doi:10.1371/journal.pone.00.  Abstract  
submitted by kickingbird at Apr, 30, 2014 from PLoS ONE 9(4): e95685. doi:10.1371/journal.pone.00 (via http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjourna)
We investigated avian influenza infections in wild birds, poultry, and humans at Eastern Dongting Lake, China. We analyzed 6,621 environmental samples, including fresh fecal and water samples, from wild ...

Michael Worobey,1, Guan-Zhu Han1, & Andrew Rambaut. A synchronized global sweep of the internal genes of modern avian influenza virus. Nature(2014)doi:10.1038/nature13016.  Abstract  
submitted by kickingbird at Apr, 25, 2014 from Nature(2014)doi:10.1038/nature13016 (via http://www.nature.com/nature/journal/vaop/ncurrent/full/natu)
Zoonotic infectious diseases such as influenza continue to pose a grave threat to human health1. However, the factors that mediate the emergence of RNA viruses such as influenza?A virus (IAV) are still ...

Juliane Straube, Jill Manteufel, Janin Heinze, Kar. Low Pathogenic Avian Influenza Viruses (H3N8, H5N6): In Vitro Influence of d,l-Lactic Acid and Sodium Chloride on Infectivity and Virus Persistence in Short Fermented Raw Poultry Sausage. Food and Environmental Virology June 2010, Volume.  Abstract  
submitted by kickingbird at Apr, 25, 2014 from Food and Environmental Virology June 2010, Volume (via http://link.springer.com/article/10.1007%2Fs12560-010-9030-9)
Since highly pathogenic avian influenza virus H5N1 emerged in 1997, avian influenza is considered one of the most important infectious diseases globally. In respect of virus transmission to humans, the ...

Vahlenkamp TW, Harder TC, Giese M, Lin F, Teifke. Protection of cats against lethal influenza H5N1 challenge infection. J Gen Virol. 2008 Apr;89(Pt 4):968-74. doi: 10.109.  Abstract  
submitted by kickingbird at Apr, 25, 2014 from J Gen Virol. 2008 Apr;89(Pt 4):968-74. doi: 10.109 (via http://www.ncbi.nlm.nih.gov/pubmed/?term=H5N6)
Highly pathogenic avian influenza virus (HPAIV) H5N1 of Asian origin continues to circulate in poultry and wild birds, causing considerable concern for veterinary and public health in Asia, Europe and ...

Rudolf M, P?ppel M, Fr?hlich A, Mettenleiter T, B. Efficacy of a commercial inactivated H5 influenza vaccine against highly pathogenic avian influenza H5N1 in waterfowl evaluated under field conditions. Rev Sci Tech. 2009 Apr;28(1):275-91.  Abstract  
submitted by kickingbird at Apr, 25, 2014 from Rev Sci Tech. 2009 Apr;28(1):275-91 (via http://www.ncbi.nlm.nih.gov/pubmed/19618632)
Highly pathogenic avian influenza virus (HPAIV) can cause devastating losses in the poultry industry. In addition, several HPAIV exhibit a zooanthroponotic potential and can cause fatal infections in ...

Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R,. A vaccine prepared from a non-pathogenic H5N1 avian influenza virus strain confers protective immunity against highly pathogenic avian influenza virus infection in cynomolgus macaques. Vaccine. 2008 Jan 24;26(4):562-72. doi: 10.1016/j..  Abstract  
submitted by kickingbird at Apr, 25, 2014 from Vaccine. 2008 Jan 24;26(4):562-72. doi: 10.1016/j. (via http://www.ncbi.nlm.nih.gov/pubmed/18164788)
In order to prepare for the emergence of pandemic influenza viruses, we have established an influenza virus library that contains non-pathogenic influenza A virus strains with 135 combinations of 15 ...

Ninomiya, mai M, Tashiro M, Odagiri T.. Inactivated influenza H5N1 whole-virus vaccine with aluminum adjuvant induces homologous and heterologous protective immunities against lethal challenge with highly pathogenic H5N1 avian influenza vir. Vaccine. 2007 May 4;25(18):3554-60. Epub 2007 Jan.  Abstract  
submitted by kickingbird at Apr, 25, 2014 from Vaccine. 2007 May 4;25(18):3554-60. Epub 2007 Jan (via http://www.ncbi.nlm.nih.gov/pubmed/17293015)
In response to recent outbreaks of H5N1 highly pathogenic avian influenza virus (HPAIV), the development of an effective H5N1 influenza vaccine is urgently important. We assessed the efficacy of two ...

Elbahesh H, Cline T, Baranovich T, Govorkova EA, e. Novel Roles of Focal Adhesion Kinase in Cytoplasmic Entry and Replication of Influenza A Viruses. J Virol. 2014 Apr 2.  Abstract  
submitted by kickingbird at Apr, 6, 2014 from J Virol. 2014 Apr 2 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24696469/)
Viruses modulate cellular signaling pathways at almost every step of the infection cycle. Cellular signaling pathways activated at later times of influenza infections have previously been investigated; ...

DERMODY TS, Sandri-Goldin RM, Shenk T. Sequence Changes Associated with Respiratory Transmission of H7N1 Influenza Virus in Mammals. J Virol. 2014.  Abstract  
submitted by kickingbird at Apr, 6, 2014 from J Virol. 2014 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24696481/)
In this issue of the Journal of Virology, we publish a paper by Troy C. Sutton and colleagues from the University of Maryland, Virginia-Maryland College of Veterinary Medicine, and the Istituto Zooprofilattico ...

SUTTON TC, Finch C, Shao H, Angel M, et al. Airborne Transmission of Highly Pathogenic H7N1 Influenza in Ferrets. J Virol. 2014.  Abstract  
submitted by kickingbird at Apr, 6, 2014 from J Virol. 2014 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24696487/)
Avian H7 influenza viruses are recognized as potential pandemic viruses as personnel often become infected during poultry outbreaks. H7 infections in humans typically cause mild conjunctivitis; however, ...

TRAPP S, Soubieux D, Marty H, Esnault E, et al. Shortening the unstructured, interdomain region of the non-structural protein NS1 of an avian H1N1 influenza virus increases its replication and pathogenicity in chickens. J Gen Virol. 2014 Apr 2. doi: 10.1099/vir.0.063776.  Abstract  
submitted by kickingbird at Apr, 6, 2014 from J Gen Virol. 2014 Apr 2. doi: 10.1099/vir.0.063776 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24694396/)
Currently circulating H5N1 influenza viruses have undergone a complex evolution since the appearance of their progenitor A/Goose/Guangdong/1/96 in 1996. After the eradication of the H5N1 viruses that emerged ...

LIU Q, Chen H, Huang J, Chen Y, et al. A nonpathogenic duck-origin H9N2 influenza A virus adapts to high pathogenicity in mice. Arch Virol. 2014.  Abstract  
submitted by kickingbird at Apr, 6, 2014 from Arch Virol. 2014 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24696271/)
H9N2 influenza viruses continue to circulate in wild birds and poultry in Eurasian countries and have repeatedly infected mammals, including pigs and humans, posing a significant threat to public health. ...

WU R, Li X, Leung HC, Cao Z, et al.. A novel neutralizing antibody against diverse clades of H5N1 influenza virus and its mutants capable of airborne transmission. Antiviral Res. 2014 Mar 25. pii: S0166-3542(14)000.  Abstract  
submitted by kickingbird at Apr, 6, 2014 from Antiviral Res. 2014 Mar 25. pii: S0166-3542(14)000 (via http://www.ncbi.nlm.nih.gov/m/pubmed/24681124/)
Highly pathogenic avian influenza A virus H5N1 continues to spread among poultry and has frequently broken the species barrier to humans. Recent studies have shown that a laboratory-mutated or reassortant ...

SCHERLIESS R, Ajmera A, Dennis M, Carroll MW, et a. Induction of protective immunity against H1N1 influenza A(H1N1)pdm09 with spray-dried and electron-beam sterilised vaccines in non-human primates. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00140.  Abstract  
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00140 (via http://www.ncbi.nlm.nih.gov/pubmed/24631078)
Currently, the need for cooled storage and the impossibility of terminal sterilisation are major drawbacks in vaccine manufacturing and distribution. To overcome current restrictions a preclinical safety ...

YAN J, Villarreal DO, Racine T, Chu JS, et al. Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine.. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00211.  Abstract  
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00211 (via http://www.ncbi.nlm.nih.gov/pubmed/24631084)
Despite an intensive vaccine program influenza infections remain a major health problem, due to the viruses' ability to change its envelope glycoprotein hemagglutinin (HA), through shift and drift, permitting ...

BANJAC M, Roethl E, Gelhart F, Kramberger P, et al. Purification of Vero cell derived live replication deficient influenza A and B virus by ion exchange monolith chromatography. Vaccine. 2014 Mar 11. pii: S0264-410X(14)00313.  Abstract  
submitted by kickingbird at Mar, 23, 2014 from Vaccine. 2014 Mar 11. pii: S0264-410X(14)00313 (via http://www.ncbi.nlm.nih.gov/pubmed/24631091)
We explored the possibilities for purification of various ΔNS1 live, replication deficient influenza viruses on ion exchange methacrylate monoliths. Influenza A ΔNS1-H1N1, ΔNS1-H3N2, ΔNS1-H5N1 and ΔNS1-influenza ...

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